Stem Cell Therapy for Alzheimer




Alzheimer is the severe version of dementia named after the neurologist Dr. Alois Alzheimer. It is a kind of progressive neurodegenerative disorder associated with the gradual loss of cognitive functions such as thinking, memory, reasoning and behavioral skills. The Alzheimer disease initially affects its victim subtly with the preliminary symptoms being disorientation and memory loss, but in later stages the disease can progress to an extent of complete dependency on others for the basic activities of daily living. Research suggests that a host of factors beyond genetics and age, are responsible for the onset and development of this disorder.

Like all other forms of dementia, Alzheimer is also caused due to severe nerve damage, mainly due to the formation of proteinaceous plaques and tangles. There are two distinct hallmarks of Alzheimer's mainly deposition of tangles inside the brain cells and amyloid proteins clogging the spaces between the neurons, these formation hampers smooth passage of signals from motor neurons ultimately resulting in their death or degeneration. The root cause of these formations is still to be identified, but scientists are relating some epigenetic changes to be associated with them.

The strong progressive neurodegeneration has identified to be mainly responsible factor for the observed memory failure, personality changes and difficulty coping with the day to day activity.


Major Manifestations of Alzheimer's, in patients include the following:

  • Memory Loss
  • Difficulty performing familiar tasks
  • Disorientation to time and places
  • Poor or decreased judgement
  • Problems with the abstract thinking
  • Misplacing things
  • Changes in mood or behavior
  • Changes in personality
  • Loss of initiative

Conventionally only supportive treatments were present to temporarily relieve the pain or the symptoms, additionally there are many support services available for the effective management of some activities and programs such as day care services or nursing programs. Although the damage in terms of death of neurons cannot be halted or reversed with this treatment approach till the discovery of stem cells.

Stem cells are the master cells of the body, mainly differentiating into the required type of cells upon administering a proper cocktail of growth factors and stimulatory agents in vitro. The stem cell therapy approach mainly focuses on delivering the sufficient number of Adult Autologous Stem Cells which will travel into multiple areas of the brain where the damage has occurred.These transplanted stem cells are potential to transform into new brain cells which are needed for the replacement of damaged cells. They also help in creating a microenvironment that will secret some of the enzymes required for making connections to replace lost parts of the complex network.

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Stem Cell Treatment

Stem Cell Treatment For Alzheimer's: Advancells Protocol

At Advancells, we have been successfully treating patients with neurodegenerative disorders using autologous stem cells. Our top priority is to provide very comprehensive, individualized treatment pattern which is best suited for the patients undergoing dementia/Alzheimer's treatment. As a part of our treatment, patient's stem cell are obtained from two sources Adipose-derived Stem Cells (ASCs) & Bone Marrow-derived Stem cells (BMSCs). Sometimes we may use a combination of both, depending upon the assessment. Since body's own cells are used, the technique is very safe with no side effects, non invasive and effective.

Step 1- Qualification For The Treatment

A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pretreatment assessments can be suggested depending upon the patient's medical and family background:

Pre-Treatment Assessments

  • Routine Blood Tests
  • Routine Urine Analysis
  • Infectious disease testing
  • Physical Examination
  • X Ray

Pre-Operative Assessments

  • MRI
  • CT Scan
  • Neurophysiology
  • Medical Neurological Reports
  • Medical History
  • Counselling

As per these results, the patient will be counseled further for final decision of protocol.

Step 2- Source Extraction

With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolated from Bone Marrow or Adipose Tissue, as these are the most potent autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cells stimulation therapy for some, depending upon the severity and requirement.

The specified amount of samples will be extracted from the patient's own body on the intimated date and time, with the application of local anesthesia. The entire procedure takes around 7-8 hrs, however, in case of extraction from both the sources the patient has to be with us for a little longer time.

If you are curious to know more about the procedure, kindly refer our detailed snapshot below :

stem cell treatment for ALS

Step 3- Laboratory Processing

The extracted sample, will be sent to the government approved cGMP laboratory for processing. The sample processing will be done in a state of the art class 10,000 clean room in compliance with the ISO and GMP standards.

The sample will undergo minimum manipulation in our complete automated Sepax technology to be enriched with the pure population of stem cell culture. The isolated stem cells will be characterized for quality, purity and viability.

The client will be given a third party certificate from Internationally Accredited Lab for the quality purpose.

Step 4- Stem Cell Implantation

Once stem cells are enriched and ready to be injected back into the body, we have worked on different modes of implanting them. However, depending upon the patient's physiological and mental well being, one of the following will be finalized by our experts.

  • Intravenous Injection:- Stem cells will be infused into the body, by infusing through the vein.
  • Intra-thecal Injection:- Stem cells will be infused, into the cerebro-spinal fluid into the spinal canal. This route is most popularly known as Lumbar Puncture.

Follow up Treatment

In a post treatment care, the patient will be asked to visit the doctors after a specific period of time, for some rehabilitation programs, including Behavioural and emotional development, Communication and social Interaction, Self regulation, Cognitive & Adaptive skills.


Alzheimer Stem Cell Treatment Results

Once treated patients are allowed to return to their home or hotel on the same day. Only in certain cases a day's stay at the clinic will be advised.

The majority of the patients, have shown improvement in their behaviour, thinkin and memory pattern.

Patient's Stories

Josephine Stramiello - 82 years old

"...I was taking Aricept and gradually losing my ability to think clearly"

Giulia Serafini, 78 years, Dementia

"...One day I noticed that my mother began to forget things. During..."



Frequently Asked Questions

  • What Is Alzheimer's Disease?
  • Alzheimer's is a severe form of dementia, a kind of a brain disease progressively damaging memory and thinking skills. The person can eventually lose its independence even for day to day activities.
  • What are the signs and symptoms of Alzheimer's Disease ?
  • A person with his early disease developmental stage may find difficulty in remembering things, he can ask the same questions again and again, have trouble managing finances, taking longer than normal to finish daily tasks. A person may also face difficulty in finding the right words in his speech, impaired reasoning or judgmental abilities. He or she may as well experience mood swings or personality changes.
  • What causes Alzheimer Disease?
  • Except for a rare form of Alzheimer, called early onset familial Alzheimer's Disease other forms of diseases are non genetic. Genetic mutations are linked with the type of an Alzheimer, whereas others are directly linked with environmental factors and traumatic situation faced by the body.
  • How Alzheimer disease is diagnosed?
  • The only way to diagnose a disease is to find out whether plaques and tangles are present in the section of the brain. To look into the tissue, the doctor has to perform brain biopsy test or brain autopsy test, an examination of the brain done after the person dies. When the person is alive, the diagnosis is fully dependent upon the possibility or probability through examination of general health, past medical problems, family history, asking questions about personality changes, memory tests, language skills, problem solving capacity, attention.
  • How long do people live after diagnosis ?
  • Although the time from diagnosis to death varied from person to person, it can be as little as 3 to 5 years for the person above 80 years of age. For younger patients time may vary between 7-10 years.
  • Where can I get more information about Alzheimer's Disease?
  • Please go through, our treatment brochures for other Alzheimer's Disease related information.


What can you expect?

Many Alzheimer's patients after stem cell treatment reported to be exhibiting:

  • Improved short term memory loss
  • Self confidence and good control over day to day activity
  • Improved concentration
  • Improved self regulation
  • Better tolerability of daily chores
  • Improved quality of life
  • Complete stoppage of progression of the disease

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