Ankylosing Spondylitis is a kind of systemic arthritis, mainly affecting the spinal and sacroiliac joints, although not restricted to it. Rather it is a multisystem spondyloarthropathies belonging to the group of arthritis, tending to cause pain and stiffness to all over the joints with the major emhasis on spine, that in turn is associated with chronic inflammation. Although the disease is believed to be having a strong genetic predisposition, as the majority of people with AS are born with the activation of HLA-B27 gene, it has been observed that more men than women are affected at their young adulthood upto the age of 40 years.
The human backbone or the spine is made up of 24 different vertebrae and 9 fused vertebrae. Thus out of the total 33 vetebrae, 24 are separated from each other with the help of intervertebral discs and the other nine are fused completely, situated mainly in the lower back such as sacrum or coccyx in adults. The Ankylosing Spondylitis is associated with the ossification or remodelling of the outer fibrous rings of those intervertebral discs, that in turn causes fusion or growth of the vertebrates. Due to this fusion, stiffness of the spine is developed imparting lot of pressure on the lower back.
Although, it is still not clear as to how this inflammation develops and be persistent, it has been observed that each individual portrays different pattern after the activation of body's immune system; may be with the initial bacterial infection or combination of infectious microbes or may be due to another systemic infections. However, once activated, the body's immune system is unable to deactivate itself even after the initial infection is subsided. This autoimmunity of the individual is thought to be responsible for spinal remodelling and fusion heading towards the onset of Ankylosing Spondylitis.
The signs and symptoms of the disease, are often irrational with the initial onset of the condition may be at the age of early 20's till late 40's. The initial symptoms of the disorder can usually be a chronic,persistent,dull pain in the lower back region of the spine combined with the rigidity or stiffness of the backbone. With the progression of the disease, the person can observe a complete loss of spinal mobility, causing forward curvature of the upper torso or the thoracic spine, limiting his breathing capacity. In order to sustain the condition, a chest expansion is observed along with the extension of the lumbar spine. Due to these modifications, AS can cause serious scarring of the lungs causing excessive coughing and breathing difficulty. Being a systemic disorder, people with AS have arthritis in joints other than the spine, they may as well experience a pain or a stiffness in other areas of the body such as knees, hips, ankles, toes, etc. In more serious, progressive forms of the AS, vital organs of the body such as eyes, kidneys, heart are also affected with the inflammation.
Thus, in general the key components of the patients history suggesting the AS are as follows:
- Persistent lower back pain
- Pain in joints along with the lower back worsening in the morning or after heavy physical activity.
- Breathing shortness and/or fatigue.
- Stooped posture, excessive coughing
- Constitutional and organ specific manifestations such as renal disease, pulmonary disease, metabolic bone disease, etc.
- Enthesitis, the inflammation of the tendons or the ligaments.
Various clinical criterias are combined for the diagnosis of the AS, such as back pain, family history of arthritis, stooped posture, which are confirmed with the help of radiological findings such as Doppler sonography, MRI and CT scanning. As such there is no complete cure for the disorder available, however traditional rehabilitative treatments involve certain steroidal medications or joint surgeries like vertebral osteotomy, fracture stabilization or joint replacements. However, these treatments are proven to be supportive, unable to promote neither stoppage of progression nor complete reversal of the damage.
Thus there have always been a strong need of the one stop solutions for all the arthritis related issues of the individual suffering from AS.
Autologous exploitation of stem cells isolated from the richest sources of the body, such as Bone Marrow and/or Adipose Tissue, have clinically proven to be very helpful in managing arthritic disorders including but not limited to AS. Although the complete reversal of the pathophysiology has so far not observed, the progression of the disease can be stopped to a significant extent.
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Stem Cell Treatment For Ankylosing Spondylitis: Advancells Protocol
Here at Advancells, stem cell treatment is offered for all the forms of arthritis, including AS, by re-infusing back patient's own cells isolated from the richest autologous tissues such as Bone Marrow and/or Adipose Tissue for achieving successful results. The non surgical process, stop the progression of the damage associated with autoimmunity of the body's own immune system by regeneration of the new cells that alters the need for having dangerous steroidal drugs with the hazardous side effects or painful joint replacement surgeries. Thus Advancells, has been effortlessly treating individuals overcome all their arthritic issues and degeneration problems to achieve a better quality of life and health.
These stem cells when injected inside the site of injury, can initiate cascade of immune responses to facilitate repair of damaged cells and regeneration of new cells that have been lost due to faulty process. Advancells is facilitated by prodigious prospects of stem cells in treating various diseases, hence we are constantly updating our knowledge to suit unique specifications of each patients.
Our principle objectives have always been a cessation of disease progression and easing the quality of life to a considerable extent. We are always pledged to deliver safe treatment pattern, by offering "Autologous stem cells from your own Bone Marrow/Adipose Tissue
Our top priority is to provide very comprehensive, tailor made treatment pattern with the maximum recovery. As a part of our treatment, patient's stem cell are obtained from two sources adipose-derived stem cells (ASCs) and bone marrow-derived stem cells (BMSCs). Sometimes we may use a combination of both, depending upon the assessment.
Step 1- Qualification For The Treatment
A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pretreatment assessments can be suggested depending upon the patient's medical and family background:
- Infectious Disease Testing
- Routine Blood tests
- Physical Examination
- X ray
- Medical Reports & History
As per these results, the patient will be counseled further for final decision of protocol.
Step 2- Source Extraction
With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolated from Bone Marrow or Adipose Tissue, as these are the most potent autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cell stimulation therapy for some, depending upon the severity and requirement.
The specified amount of samples will be extracted from the patient's own body on the intimated date and time, with the application of local anesthesia. The entire procedure takes around 7-8 hrs, however, in case of extracted from both the sources the patient has to be with us for a little longer time.
If you are curious to know more about the procedure, kindly refer our detailed snapshot below:
Step 3- Laboratory Processing
The extracted sample, will be sent to the government approved cGMP laboratory for processing. The sample processing will be done in a state of the art class 10,000 clean room in compliance with the ISO and GMP standards.
The sample will undergo minimum manipulation in our complete automated Sepax technology to be enriched with the pure population of stem cell culture. The isolated stem cells will be characterized for quality, purity and viability.
The client will be given a third party certificate from Internationally Accredited Lab for the quality purpose.
Step 4- Stem Cell Implantation
Once stem cells are enriched and ready to be injected back into the body, we have worked on different modes of implanting them. However, depending upon the patient's physiological and mental well being, one of the following will be finalized by our experts.
- Intravenous Injection:- Stem cells will be infused into the body, by infusing through the vein.
- Intra-thecal Injection:- Stem cells will be infused, into the cerebro-spinal fluid of the spinal cord. This route is most popularly known as Lumbar Puncture.
Follow up Treatment
Post treatment, the patient will be asked to visit the doctors for reclamation therapies such as Physiotherapy, patients counselling etc. for accelerated recovery.
Ankylosing Spondylitis Stem Cell Treatment Results
Ten patients mean age = 45 years (Sex ratio; 2 male: 3 female) with chronic knee pain unresponsive to conservative treatments and radiologic evidence of degenerative arthritis were treated with autologous bone marrow stem cells by intra-articular injection (Read more...)
Rahul, 25 years, Ankylosing Spondylitis
Rahul was suffering from Ankylosing Spondilytis since past 14 years. Painful joints, restricted movements and stiffness in the body was his way of life. Although Rahul doesn't have any family history of joint diseases. Although Rahul was very unwilling to let this chronic disease take over him, and desperately wanted some new treatment or modern medicine, which will help him to get back to the life again. With lot of research and through understanding of stem cells, he opted to be treated with stem cells under the guidance of Advancell's team.
Owen Cooke, 61 years, Osteoarthritis and Foot Damage
"..."Overall, I am very, very pleased with the result so far..."
Malcolm Pasley, Osteoarthritis (Knee)
"...I notice a huge improvement in both knees..."
Robert Da Prato, 64 years, Osteoarthritis - Knees
"...I am happy. Perhaps in a few more months, my situation will improve..."
Wendy Funston, 57 years, Arthritis in Hands, Knees, Feet, Elbows
"...since treatment I HAVE BEEN PAIN FREE!!!!..."
R. Karan, 60 Years Old, Lumbar spondylosis treatment
Manav, Ankylosing spondylosis treatment Video
Frequently Asked Questions
- What is Inflammatory Spondylopathy?
- Spondylopathy is a group of disorder, involving many chronic joint issues. Although, different disorders coming under this group have different pathophysiology; the generalized symptoms of all of them are the same. On a general note, symptoms associated with the disorder include stiffness in the joints and thereby restricted movements along with the changes associated with the postures.
- What are the assessments related to AS?
- The assessments of the AS are done with the help of series of questionnaires that will help your doctor to work out the best way to manage with your difficulty. You may be assessed as mentioned below:
Additionally, other clinical assessments are done such as spinal X rays, Specific blood tests like haemoglobin, ESR and CRP.¬† Specific genetic tests may also be done including HLA-B27, RA, etc. The patient may also be prescribed some other radiological confirmations such as MRI, X Ray, CT Scan, etc.
- The Bath Ankylosing Spondylitis score measures the main symptoms of AS such as fatigue, back pain, morning stiffness. The score is recorded out of 10 basis, more the score is,worst are the symtoms.
- The spinal pain can also measured with reference to Bath Ankylosing Spondylitis score and may be recorded separately.
- The Bath Ankylosing Functional Index is scored according to how much your disorder is affecting your ability to carry out day to day tasks.
- The work productivity and activity impairement score measures your ability to work during the last week, be it in a job or home.
- What are the typical AS symptoms?
General AS symptoms include painful stiffness of the lower back, hips, etc. worsening normally in the morning. Over the period of time, the pain and stiffness may progresses towards the spine and other joints. The person with AS, may show stooped posture, inability to work independently and reduced mobility. Gradually, he may also notice difficulty in bending the spine. Features such as loss of appetite, fatigue, weight loss, inflammation of the eye and/or other muscular organs of the body, may also be observed.
- I think I have an AS, where can I get help?
- If you experiencing any of the above mentioned, AS symptoms, you should immediately visit an orthopaedic surgeon. To know more about the complication associated with the disorders, possible treatment options and how novel stem cells treatment can help you to manage with your progressive disorders, you can visit our website, www.advancells.com.
- What actually happens in AS?
- If you are suffering from chronic AS, your spinal vertebrae are completely fused not allowing movement flexibility to your backbone. This results in the severe inflammation of the joints, change in the body posture, expansion in the chest skeleton and progressive stiffness of all the joints of your body. In the later progression, the disease may affect you breathing capacity, independency as well as other vital muscular organs of the body such as eye, heart, kidney, etc. The disorder is often called as the ‚Äúbaboo spine‚ÄĚ because your spine tends to get stiff like a bamboo.
- What are the factors responsible for AS?
- Although, the exact causes are not known, the people expressing HLA-B27 genes are known to be more prone for the same. In the background, various factors are observed to be responsible for the gene activation such as autoimmunity, systemic infection, metabolic disorders, etc.
- Can AS cause any disability in me?
Mild, moderate or severe disabilities have been experienced by many of the people with AS, depending upon the progression of the disease and immunity level. As every person portrays different manifestations, the severity of the disease varies from person to person. If well managed in the initial stages, it is very likely that the progression can be stopped.
- What are the traditional treatments for my AS? Are they Helpful?
As such with the help of traditional medicine, no complete cure is available for your AS, however doctors can suggest some steroidal medications to keep you going. Although, long term use of steroids can be harmful to overall health of the body, causing various hazardous side effects. Depending upon the severity of the disease, doctors can as well suggest joint replacement surgeries which are indeed very painful, attracting many opportunistic infections.
- Is their any alternative to traditional medicines? What are the benefits?
Yes, Stem cells treatment is the unique alternative approach presented to you by the modern medicine, to help you reverse back your damage associated with the disease without any harmful side effects or surgeries.
- What are stem cells and how they can be helpful?
Stem cells are the unique, pristine cells; isolated from the richest sources of your own body such as Bone Marrow and/or Adipose Tissue. These cells are proved to be having a potential to alter into many different cells of variety of other lineages in your body upon proper signalling. So far, these cells have been exploited successfully to differentiate into neurogenic, osteogenic, chondrogenic, blood lineages. These cells can be isolated outside the body, enriched in a clean environment and implanted back at the site of injury to promote regeneration of lost cells, repairing damaged ones, and enhance the overall functional capacity of the organ.
- Where can I get more information about the diseases?
- Please go through our treatment brochures for other orthopaedic related diseases