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Stem cell Therapy for Periodontal Disease
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Introduction

Periodontal Disease Treatment

Periodontal Disease

Periodontitis is an infectious and inflammatory oral issue, leading to the periodontal tissue destruction and has been pinpointed as the main reason for tooth loss. Further to which, the said destruction may lead to dysfunctional as well as aesthetically questionable dentition. It has been surveyed that more commonly, around 35% of the adults suffer from moderate periodontitis, while 15% of affected people exhibit severely generalized periodontitis at some or the other phase of life. Although, conventional therapeutic options can successfully delay periodontal inflammation; however, it can’t reverse the damaged periodontium. Thus, there has been an increased interest in the disease management with the application of regenerative medicine, and improve patient’s quality of life.

In this regard, the aim of stem cells derived periodontal regenerative treatment is to restore the physiological functions of teeth by rebuilding supporting tissues. With this novel concept, it can be possible to repair damaged periodontal tissues through combined efforts of autologous mesenchymal stem cells, secreted growth factors and extracellular matrix scaffolds. This unique concept triggering direct tissue regeneration has been recently emphasized in all periodontal tissue reconstruction to decrease wait time and increase clinical outcome.

In this regard, we have adapted a multidisciplinary approach towards engineering periodontal tissues, like alveolar bone, gingiva, periodontal ligaments as well as cementum; through the systemic integration of multiple progenitor stem cells isolated from dental pulp tissues, growth factors to support cellular signaling and conductive extracellular matrix scaffold to be able to provide chemical as well as mechanical cues, thus promoting multicellular interactions, orchestrate cellular adhesion, migration and differentiation into a desired cellular lineage.

Accordingly, often silent gum diseases or periodontal diseases may not trigger or initiate symptomatic display of its state unless it is spread in an advanced stage. However, some of the warning indications can be noted down as:

  • Red, swollen, tender gums in the mouth that are very painful at times.
  • Bleeding while brushing, flossing or eating hard food.
  • Gums that are receding or pulling away from the teeth, causing teeth to look longer than before
  • Loose or separating teeth.
  • Pus between the gums and teeth.
  • Mouth sores and ulcers.
  • Persistent bad breath.
  • Change in the way your teeth fit together while biting.
  • A change in the fit of partial dentures

Results of Periodontal Tissue Regeneration through Dental Pulp Derived Stem cells and Biodegradable Scaffolds.

Although, conventional periodontal therapy, involving many of the mechanical and surgical procedures, largely promotes only rectification of supportive soft tissues, without any virtual repairing of bones as well as cementum; it does not constitute reversal of damaged tissue. In this regard, latest technology can be helpful in promoting guided tissue regeneration through introduction of physical barrier for maximizing access of dental pulp derived mesenchymal stem cells, for promoting hard tissue development.

This novel, potential tissue reconstruction approach can be proposed to treat various periodontal diseases through incorporation of mesenchymal stem cells and growth factors in a pre-fabricated three-dimensional construct.

This advanced concept of cell-based regeneration of craniofacial tissues can provide a great impact on treatment outcome. Conversely, studies have suggested application of dental pulp derived mesenchymal stem cells to be having proven capacity to differentiate into different cells; signifying their key role in several clinical pathologies of regenerative endodontics.

Although, periodontal diseases become more common; tissue engineering with non-invasive, modern technology is attracting many people as an effective substitute over traditional, painful procedure.

List of diseases treated

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Treatment

Stem Cell Treatment For Dental Pulp: Advancells Protocol

Periodontal diseases have been surveyed as the growing issue leading to the tissue destruction and tooth loss and is identified as one of the common procedures that require sufficient training, due to its regional inherent challenges. Moreover, disease stimulated teeth loss can further accentuate bone deficiency, further complicating surgical mode of bone grafting and remodeling. Thus, in order to adapt, circumvent and treat these local physiological as well as anatomical limitations; regenerative, reconstruction of bony platform with application of regenerative medicine and modern tissue engineering technology can be emphasized for natural, tailored lifting of sinus membrane, for their functional restoration.

In this regard, the site, size and associated soft tissue defects represent the three most important factors; in determining the impact of treatment procedure on functional restoration and aesthetics.

Our process of periodontal tissue regeneration involves three key elements, which include:

  • Inductive soluble growth factors.
  • Stem cells isolated from dental pulp tissue.
  • Biocompatible scaffolds made up of Xeno/Allo/Synthetic substitutes.

Accordingly, steps involved in the procedures are:

Step 1- Qualification For The Treatment

A safety and efficacy assessments will be prescribed by our experts in order to investigate a degree of severity and a need to undergo particular treatment. Following pretreatment assessments can be suggested.

Pre-Treatment Assessments

  • Infectious Disease Testing
  • Physical Examination
  • Medical Reports & History
  • Panorex X Rays
  • Cephalometric X Rays
  • Models & Impressions
  • Radiographic Images

As per the results, the patient will be further counselled for final treatment that will impact proper jaw functions and an aesthetic appearance of an entire face.

Step 2- Source Extraction

Mesenchymal stem cells and/or neural crest derived stem cells isolated from soft tissue of the wisdom tooth has been confirmed to be the most potent, non-invasive source of stem cells with high proliferation rate, higher degree of differentiation and a better capacity to interact with biocompatible matrices and growth factors for faster regeneration and healing.

Thus, Dental Pulp stem cells sourced from either wisdom tooth or milk tooth, that are already planned to remove will be collected as a better fitting tool due to easy access, and a very low morbidity of the anatomical site.

Stem Cell Therapy Procedure for Periodontal Disease

Step 3- Laboratory Processing

Tissue samples containing stem cells will be transported to our ultramodern GMP grade facility, through placing it, in a screw top vial containing appropriate transportation media; which may nourish it during transportation. Mesenchymal stem cells and/or neural crest derived stem cells will be isolated from a soft dental pulp tissue, which is encased inside a bony cavity of wisdom tooth or milk tooth; under controlled sterile conditions.

Step 4- Stem Cell Implantation

Expanded stem cells will be loaded on a suitable matrix called as scaffold to allow speedy attachment, faster regeneration into specific cell types and easy proliferation. Although scaffolds are of different types, shapes, patterns as well as biocompatible materials; depending upon the necessity, capacity and costing it can be made up of Xeno/Allo/Synthetic substitute.

Tissue Reconstruction through Biodegradable Scaffolds: - We have wide range of ideal scaffolds made up of different biocompatible materials, to provide chemical stability, physical strength and mimicking the surrounding tissue with respect to faster cellular proliferation, better adhesion performance, controlled degradation, easy differentiation and better integration.

A scaffold will further be implanted and secured in a position above and/or below jawline; depending upon the clinical condition to allow faster reconstruction and speedy healing of jawbones.

Step 5- Maintenance & Follow Up

Following the completion of implants, patients are advised to thoroughly clean around the implants as instructed by our dental hygienist. Patients will be called for the regular review so that the health and the integrity of the soft tissues and other bones can be evaluated.

 

FAQ's

Frequently Asked Questions

  • What are Periodontal Diseases?
  • Periodontal diseases are commonly identified as the gum diseases are progressive issues, which if ignored or left untreated for longer time duration; may result in serious consequences, such as tooth loss. Periodontitis or gum disorders may initially begin with the inflammation or swelling in the gum that may slowly start irritating surrounding gingival tissues that are supporting the teeth.
  • What are common indications of Gum Disorders?
  • Various clinical investigations and statistical analysis have suggested various genetic as well as environmental factors to be responsible for the onset of gum disorders. In any case, below mentioned list of common causes can help you to prevent periodontal diseases, through proper precautions.
    • Poor Dental Hygiene
    • Usage of Tobacco
    • Genetic Predisposition
    • Pregnancy and menopause
    • Chronic Stress and Poor diet
    • Diabetes and underlying medical issues
    • Grinding Teeth
    • Medications
  • What are the symptoms of Periodontal Infections?
  • Since, these infections grow under the gums; they cannot trigger any symptoms at all.
    Patients with more advanced periodontal disease, may experience some of the following symptoms:
    • Swollen, red and/or tender gums
    • Tooth sensitivity to heat and cold
    • Bad breath
    • Deep pockets around teeth
    • Spaces between the teeth
    • Loose and/or shifting teeth
    • Missing teeth
    • Gums receding around the teeth
  • How can periodontal diseases be treated?
  • Periodontal Disease is a gum and jawbone infection; accordingly, a treatment goal should be to remove infection, through natural integration of body’s own cellular mechanism and an extensive array of latest technologies to minimize procedural discomfort. Thus, combining regenerative potential of stem cells with biocompatible scaffolds, can be a promising strategy for natural development of diseased or damaged soft tissues, in the periodontal cavities, such as gums.
  • How can I be benefitted through this treatment?
  • Today, a great smile can be listed as one of the primary attributes that reflects well on one’s personality; to have that positive impact from the social and professional aspects. Although, cosmetic dentistry is not just limited to the pretty smiles, but also about ensuring excellent, personalized care and better treatment outcome; hence, with new techniques and materials available with us, we are able to notice better functional outcome.

 

What can you expect?

Treatment Advantages over Conventional Surgeries:

  • Better treatment outcome without any surgery.
  • Complete removal of bacteria and other deposits from the gum pockets.
  • Improvement in bad breath (Halitosis) and complete alleviation of irritation.
  • Prevention of further breakdown of bone and gum, supporting your teeth.
  • Shorter recovery period and complete patient safety.