Kidney diseases occur when one suffers from a gradual and usually permanent loss of kidney function over time. Kidney disorders are one of the cosmopolitan diseases affecting many people. Transplantation offers a hope for cure, but many die due to the shortage of organ; those who are lucky to get the transplants, run the risk of immune rejection.
Kidneys are the two bean shaped filtering units positioned at the back side of our body. They are anatomically made up of tiny structures known as Nephrons. These nephrons are the key regulators responsible for normal functioning of the kidneys. They filter the blood, retain back its normal salts, mineral contents and flush out toxins from the body through urine. Damage to these nephrons, as in case of most of the kidney disorders, drops down the kidney function to the serious threshold giving an alarming signal.
Kidney disorders may be "Acute" or "Chronic". The acute Renal disease is characterized by temporary functional loss due to traumatic injury, obstruction in the blood flow towards the kidney or pregnancy associated complications; whereas chronic kidney diseases are associated with the dysfunctional kidneys for more than 3 months. The disease is often asymptomatic; rooted in abnormal immune conditions, urinary tract infections, inflammation, congenital birth defects, overdose of medications, etc. Due to this abnormality waste products and fluid build up is accumulated in the body causing weakness, vomiting, ankle swelling and/ or poor sleep. Untreated kidney failure is a serious and fatal condition.
Thus, considering these facts, some of the commonly associated symptoms have been listed out here:
IgA nephropathy or Bergerâ€™s disease is a kind of kidney disease, occurring when a self-tolerant antibody identified as immunoglobulin A (IgA) are encountered in the circulation, within kidneys and attack back on them. This results in local inflammation and if ignored for a longer period of time can hamper their ability to filter toxic compounds and waste material from the blood.
Immunoglobulin A is a circulating antibody, functioning an important role of protecting our body through invading pathogens and bacteria. However, in case of Bergerâ€™s disease, these antibodies get trapped and accumulated in the kidneys, and may affect filtration abilities of them through glomerular inflammation. Although, the exact cause of this deposition is unknown, some scientists have found a link to relate their presence with genetic predisposition, existing liver disease and some intestinal issues.
It is a slowly progressive disorder, with uncertain course of developments that is variable from patient to patient. Some people have reported blood leakage in the urine, without any considerable problems; whereas some others have eventually reported complete remission and end-stage kidney failure.
Through conventional medicine, no effective cure is available for the condition; however, with the advances in alternative medical technologies, it is possible to regulate bodyâ€™s immune system through application of stem cells therapy. Moreover, it may also regularize blood pressure and reduce cholesterol levels; as evident in various clinical studies.
As such, no symptoms are reported in very early stage of the disease; although, in progressive stage, it can be suspected, if, red blood cells are detected in the urine.
Other signs and symptoms of impaired kidney functions through Bergerâ€™s disease may be noted as:
Cola or tea colored urine, as a result of secretion of red blood cells in the urine.
Noticeable pain in the lateral sides of back, below ribs.
Swelling in hands and feet
Loss of Flexibility
High blood pressure
The conventional treatment for kidney disorders involve some oral steroidal medicines for an anti-inflammation. In critical conditions, the patients can be advised to be on dialysis frequently. However, this can be taken as only supplementary treatments and to regain back the normal kidney function, kidney transplant is the only available option. Additionally, life long supplementation of steroidal medicines can be very harmful to the body.
Thus, medical fraternity had been always in search of some alternative treatment options to avoid steroids and kidney transplantation. Stem cell treatment can be the best choice for nephrological issues.
Stem cells are the naive cells of the body, which can be differentiated into many cells upon proper activation. This remarkable property of stem cells can be exploited to treat a variety of medical problems. From the loads of data, available from various clinical trials; it has been observed that stem cells once injected into the body, can release some proteins, growth factors and cytokines, to promote the growth of kidney cells and proximal tubular epithelial cells. Although a lot of research is still under way, stem cells can definitely stop the progression of the disease.
Stem Cell Treatment For Kidney Disorder: Advancells Protocol
At Advancells, we aim on barring the progression of the diseased condition with more emphasis on repealing of the damaged tissue. That can certainly be fulfilled with the invention of stem cell therapy. These stem cells can be directly employed at the site of kidney damage with the catheter based injections, wherein they can facilitate regeneration of damaged nephrons by producing new podocytes, thus aiding in Kidney failure treatment. This strategy of using your own cells can also be helpful to reduce the risk associated with the immune rejection in terms of organ transplantation.
After the detailed study and research we would like to offer; a treatment regimen for kidney disorders in terms of "Autologous Stem Cells isolated from Bone Marrow/Adipose Tissue". Our top priority is to provide very comprehensive, individualized treatment pattern which is best suited for the patients undergoing treatment. As a part of our treatment, patient's stem cell are obtained from two sources adipose-derived stem cells (ASCs) and bone marrow-derived stem cells (BMSCs). Sometimes we may use a combination of both, depending upon the assessment.
Step 1- Qualification For The Treatment
A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pretreatment assessments can be suggested depending upon the patient's medical and family background:
Infectious Disease Testing
Routine Blood tests
Specific blood tests such as KFT
Serum electrolyte modification
Medical Nephrological Reports & History
As per these results, the patient will be counselled further for final decision of protocol..
Step 2- Source Extraction
With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolated from Bone Marrow or Adipose Tissue, as these are the most potent Autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cell stimulation therapy for some, depending upon the severity and requirement.
The specified amount of samples will be extracted from the patient's own body on the intimated date and time, with the application of local anesthesia. The entire procedure takes around 7-8 hrs, however, in case of extracted from both the sources the patient has to be with us for a little longer time.
If you are curious to know more about the procedure, kindly refer our detailed snapshot below:
Chronic renal failure patients showed promising results that may provide a new hope for those patients suffering from such morbid disease in improving patient's quality of life and leading to less frequent hemodialysis or avoid dialysis. Read More..
How does Kidney failure can affect a person's health?
Although symptoms can vary according to the patients, commonly; fatigue, loss of appetite, muscle cramps is observed. These problems are mainly caused due to waste product deposition in the blood, the condition is commonly known Uremia.
Can Uremia be avoided?
People with uremia can avoid the problems associated with it by opting for regular dialysis and limiting food containing salts such as sodium, potassium and phosphorus. They are also advised to visit a specialist called a nephrologist regularly, to track the progression of the disease.
What problems can offer during hemodialysis?
Hemodialysis, is a kind of dialysis that uses a machine to circulate blood through a filter outside the body. It has also been observed that for many of the patients, a rapid change in the body's water and mineral balance can cause a problem. Some of the patients can also complain about weakness, dizziness, stomach pain etc. due to the common side effects of dialysis such as muscle cramps and hypotension.
How does kidney failure affect the blood?
Anemia is another condition, affecting a person with kidney failure apart from uremia. Anemia is condition, in which the red blood cells are fewer or smaller than normal, carrying less amount of oxygen to the body's cells. The condition can also be associated with extreme fatigue and aggravation of heart problems.
The root cause of Anemic condition has been linked with decrease production of the hormone erythropoietin due to decreased kidney function. Erythropoietin is responsible for the production of red blood cells in bone marrow.
How does kidney failure affect heart and blood vessels?
Due to reduced absorption, removal of waste products and long term use of steroids; it has been observed that patients with acute or chronic kidney failure report severe blockage to the artery and other blood vessels leading to congestive heart failure.
How does kidney failure can affect the skin?
Many people, who are on dialysis complain about itchy skin, usually on the back, chest, head or limbs. This is itching is normally worse during or after dialysis, due to the deposition of waste products that are not removed from the blood. The problem can also be due to the damaged kidney's inability to balance the level of minerals, calcium and phosphorus. The itching is principle side effect of increased production of parathyroid hormone, which can cause itching.
How can kidney failure affect bones, joints and mental health?
As already discussed, kidney failure can throw off the balance of calcium, phosphorus and sodium resulting in an increased production of parathyroid hormones. These high levels of hormones, draws calcium from the bones into the blood, leaving the bones without enough calcium. The kidney failure can also cause pain ,stiffness and fluid buildup in the joints due to a condition known as " amyloidosis" . The condition is generally associated with abnormal deposition of protein known as Amyloids. It is observed that healthy kidneys are naturally able to filter amyloids but dialysis filters are not. Additionally, many patients who have been on dialysis for a longer period of time have reported insomnia and mental depression.
What are the conventional treatments offered?
Conventionally steroidal drugs, hormone supplements and exposure to UV lights were offered along with the dialysis to reduce the symptoms associated with kidney failure. However the treatment that has been offered can be dangerous with many possible side effects as discussed earlier.
Can stem cells treatment, reverse my damage?
Stem cells are the mother cells of the body, which are able to differentiate into many new cells upon proper activation. Through various clinical trials, it has been observed that they can be successfully differentiated into kidney cells or proximal epithelial cells of the inner lining of the kidney. By offering the stem cells solution, doctors can minimize the side effects associated with dialysis and oral steroidal medicines. Since cells are isolated from body's own tissues such as Bone Marrow or Adipose Tissues, these is no chance of immune rejection as with kidney transplantation and hence can be the safe alternative.
Where can I get more information about the disease?
For more information on Kidney failure and problem associated with it, you can always refer to our Treatment Brochure of Kidney Disorders.