Stem Cell Therapy for Muscular Dystrophy



Muscular Dystrophy

Muscular dystrophy is categorized as a group of one of the most catastrophic congenital birth defects provoking progressive muscular atrophies and wasting. Children with MD's are typically succumbed to paralysis and death in their twenties from respiratory or cardiac complications. The defect is consistently observed at the age of 3-5 years from when the child has difficulty in walking and controlling the body movements. As more and more muscles are compromised children develop difficulty in breathing, talking or holding themselves in an upright position.

In normal human beings; majority of muscles is formed with the bundles of cells known as "Muscle fiber cells" and "Satellite Cells". Since these muscles are mainly engaged in mobility functions, they are often depreciated due to overuse. Satellite cells act as an inbuilt repair mechanism forming new muscle fibers or fuse with the existing fibers to repair the damage. Experts believe that in muscular dystrophies the muscles are constantly damaged and these satellite cells are exhausted with the heavy burden of repairing the damage. With the destruction of satellite cells the ability of muscles to repair itself is ceased and hence muscle fibers are replaced by fat cells and scar tissues further weakening the muscles; leading to their complete loss of function.

Each variant of Muscular Dystrophy is caused by specific genetic mutations. Most of the times these mutations are inherited, but some occur spontaneously in the mother's egg or the developing embryo. Muscular dystrophy is typically diagnosed through physical examination, a family medical history, muscle biopsy and blood tests such as CPK.

The recent stem cell technology has built a new promenade for treating neuromuscular disorders like MD's; the success rate of which is quite appreciated by experts all over. Stem cells apparently are committed to be any cells of the body. Thus, in case of muscular disorders; with proper in vivo implementation at the targeted site they can be tempted to be muscle fiber cells and also can reduce the inflammation; slowing down their further deterioration.


Major Manifestations of MD, in patients include the following:

  • Frequent falls
  • Difficulty getting up from a lying or sitting position
  • Waddling gait
  • Pain in calf muscles
  • Limited range of motion
  • Learning disabilities

Conventionally, the treatment for MD involves rehabilitation in terms of physical training, occupational therapy, behavioural guidance, etc. Along with that, some anti inflammatory drugs may also be prescribed to reduce the pain associated with the same. However, all these methods have been just a supplementary with not a complete reversal of damage due to disease.

With discovery of stem cells, an alternative option is available to treat Muscular Dystrophy. Stem cells are the mother cells of the body, which can be differentiated to become any cells if directed through proper channel. These cells when inserted into the body, can reach at the site of injury secrete growth factors and other cytokine to initiate signals that can regenerate lost cells and promote healing.

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Stem Cell Treatment

Stem Cell Treatment For MD: Advancells Protocol

Advancells is excited by the prodigious prospects of stem cells in treating various diseases, hence we are constantly updating our knowledge and technology to suit unique specifications of each patient. Our principle objective has always been cessation of disease progress and easing the quality of life to a considerable extent. We have always pledged to deliver safe treatment pattern, by offering "Autologous stem cells from your own Bone Marrow/Adipose Tissue".

Our top priority is to provide very comprehensive, tailor made treatment pattern with the maximum recovery. As a part of our treatment, patient's stem cell are obtained from two sources adipose-derived stem cells (ASCs) and bone marrow-derived stem cells (BMSCs). Sometimes we may use a combination of both, depending upon the assessment.

Step 1- Qualification For The Treatment

A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pre-treatment assessments can be suggested depending upon the patient's medical and family background:

Pre-Treatment Assessments

  • Routine Blood Tests
  • Routine Urine Analysis
  • Infectious Disease Testing
  • Physical Examination
  • Aldolase, AST, LDH
  • Creatinine, Myoglobin
  • X Ray

Pre-Operative Assessments

  • Electrocardiography
  • Electromyography
  • MRI
  • CT Scan
  • Medical History MRI

As per these results, the patient will be counseled further for final decision of protocol.

Step 2- Source Extraction

With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolated from Bone Marrow or Adipose Tissue, as these are the most potent autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cell stimulation therapy for some, depending upon the severity and requirement.

The specified amount of samples will be extracted from the patient's own body on the intimated date and time, with the application of local anesthesia. The entire procedure takes around 7-8 hrs, however, in case of extracted from both the sources the patient has to be with us for a little longer time.

If you are curious to know more about the procedure, kindly refer our detailed snapshot below:

stem cell treatment for ALS

Step 3- Laboratory Processing

The extracted sample, will be sent to the government approved cGMP laboratory for processing. The sample processing will be done in a state of the art class 10,000 clean room in compliance with the ISO and GMP standards.

The sample will undergo minimum manipulation in our complete automated Sepax technology to be enriched with the pure population of stem cell culture. The isolated stem cells will be characterized for quality, purity and viability.

The client will be given a third party certificate from Internationally Accredited Lab for the quality purpose.

Step 4- Stem Cell Implantation

Once stem cells are enriched and ready to be injected back into the body, we have worked on different modes of implanting them. However, depending upon the patient's physiological and mental well being, one of the following will be finalized by our experts.

Follow up Treatment

Post treatment, the patient will be asked to visit the doctors after a specific period of time, such as rehabilitation, ultrasound, counselling to understand medical problems, evaluation and follow up.



Muscular Dystrophy Stem Cell Treatment Results

Our Muscular Dystrophy treatment objectives are to reduce pain, increase mobility and to give the best possible aid to help you return back to life.

Patient's Stories

Akhil, Muscular Dystrophy

"...Akhil has been suffering from muscular dystrophy. He was a challenging case as the patient had fibrosis tumors all over spine and body...."



Frequently Asked Questions

  • What is Muscular Dystrophy and can stem cells help?
  • MD's are a group of disorders characterized by hereditary defects in muscle protein, death of muscular cells and muscular weakness. Mutations in genes, involved in muscular membrane structure and function can also welcome the deformity. Theoretically, if stem cells are injected into the body, they can produce normal muscle cells which are non functional due to faulty genes. Some kind of stimulation can also be helpful to multiply residential stem cells and differentiate on their own to muscle cells.
  • What are the different stem cells that can offer help for MD?
  • Stem cells transplantation are of different types ranging from allogeneic mesenchymal stem cells, umbilical cord blood derived stem cells, autologous bone marrow and fat derived stem cells, etc. However, out of these, autologous mode of stem cell tansplantation is known to be the most useful as body's own cells are used they don't impose any threat of rejection of infection.
  • How many numbers of stem cells injections are required to treat MD?
  • Stem cell injection can start showing results in one injection itself, although it is difficult to interpret because the therapeutic efficacy of this treatment depends upon the patient's condition depending upon the uptake of stem cells, severity of the disease and age of the patient.
  • Does the steroidal drug therapy used as a conventional way of treating MD is useful?
  • Rehabilitation in terms of physical exercise is necessary, however strenuous way of physical exertion should be avoided. Considering steroidal therapy, it has always been proven to be medically subjective and limited in usage and hence their long term use need to be avoided. The main goal of the steroids is to reduce inflammation during muscular dystrophy. However, their long term usage can have an impact on overall physical fitness of the patient.
  • What are the chances that a patient will start walking after stem cells treatment?
  • Stem cells isolated from autologous tissue sources along with antioxidant stimulation can improve the muscular strength by regenerating muscle cells. The development has been observed in various clinical trials. However the results may vary from person to person.
    In my family if my elder brother has DMD, what are the chances of my son getting affected with the same and will stem cells injection can be an option?
    There are 50% chances of DMD deformities in your younger son. However, it has to be confirmed by molecular diagnostics and other tests. The stem cells therapy can work better in younger patients than older one. The earlier you can opt for the treatment , you will get better outcomes.
  • How can stem cells be beneficial to treat?
  • Undifferentiated adult autologous stem cells are mutable and can Metamorph into countless numbers of cells as per the requirement. This remarkable property of stem cells can be exploited for treating a variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with greater speed to to promote regeneration of muscular cells,to help control over your mood swings, to improve the physical fitness and overall mobility. Additionally a stimulation therapy can also be applied, wherein the organ is stimulated to multiply resident stem cells and secrete growth factors to create microenvironment. This treatment will act as a booster to promote regeneration.
  • Why is stem cell treatment better than conventional treatment approach?
  • Conventional treatment approach highly invasive associated with many side effects. Although stem cells can naturally heal the body from damage and regenerate lost tissue specific cells to improve impaired functions. Additionally, since body's own cells are used for repairing, the entire treatment is minimally invasive without any side effects.
  • How do I know if I am the right candidate for the stem cell treatment?
  • There are many important issues to be addressed before opting for the treatment, which can satisfactorily answered only by experts. Thus, it is always advisable to consult, and opt for the right stem cell treatment pattern.
  • Where can I get more information about Disease?
  • Please go through, our treatment brochures for other MD related information.


What can you expect?

Many MD patients after stem cell treatment reported to be exhibiting :

  • Improved control & coordination
  • Reduced Mood Swings
  • Improved physical and mental balance
  • Improved mobility
  • Improved self regulation
  • Improved quality of life
  • Complete stoppage or progression of the disease

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