Stem Cell Therapy for Osteoarthritis




Orthopaedics is the branch of medical science, concerned with the conditions involving the musculoskeletal systems. This complex system includes our bones, ligaments, tendons, muscles and nerves. All these tissues work with the great synchronization to allow us to move, work and be active. This branch involves caring for patients with all age groups, right from newborn with club feet to young athletes requiring arthroscopic surgeries to older people with arthritis. Anybody can break his bone!

Some of the commonly associated problems within this branch of medical sciences are:

  • Osteoarthritis
  • Osteomalacia
  • Osteopenia
  • Osteoporosis
  • Rheumatoid Arthritis
  • Systemic Lupus Erthromatosus Treatment
Stem cell information

Out of all the forms of arthritis, osteoarthritis is the most common form of it affecting millions of people worldwide. It is the chronic condition, occurring due to degeneration of protective cartilages, which are cushioning our joint and bones. Due to this degeneration, bones or joints are directly exposed for rubbing to each other. Due to excessive rubbing, joints are damaged, become stiff, painful and eventually associated with the loss of movements. It has been observed that although all joints in our body are at a risk of OA, however, joints of hands, knees, hips, and spine are at a greater risk. Osteoarthritis often gradually worsen as conventionally no cure exist for complete reversal of damage, although some lifestyle changes such as maintaining a balance diet, healthy weight, physical activity can promote the slow progression of the disorder.

Signs & symptoms of OA can include

  • Joint Pain
  • Joint Tenderness
  • Stiffness
  • Loss of Flexibility
  • Grating sensation
  • Bone Spurs
Stem cell information

Osteomalacia is the milder form of bone disorder, often associated with softer bone tissue mostly due to vitamin D deficiency. It is a kind of physical deformity which can be linked up directly with the softer bones. Soft bones are more likely to bend or bow or fracture as compared to healthy bones.

However, it is an important factor that Osteomalacia and Osteoporosis or Osteopenia are very different from each other as Osteoporosis or Osteopenia is the weakening or loss of previously constructed bones but Osteomalacia is the defect in the bone building process itself. For that matter, there is no age limit to this particular deformity. It can also happen in childhood, which is commonly known as Rickets.

Human bones are constantly formed through a process known as Bone Remodelling. Older bones are destroyed from the body through the process known as Bone Resorption. Through this process osteoclasts are used to break down the bone and release minerals and calcium from the bones into the blood. It is observed that this bone resorption is more in Osteomalacia due to some medical conditions such as hyperthyroidism or hypocalcemia etc. The two very important causes of the condition are found to be

  • Insufficient calcium absorption from the intestine because of lack of dietary calcium
  • Phosphate deficiency caused by increasing loss of phosphates or other minerals through urine.

Some of the common indications of the disease can be

  • Pain is linking up with major bones, such as spinal bone, hip bones, femur bones of the leg.
  • Muscle weakness or vertebrae compression
  • Hypocalcaemia
  • Pelvic flattening
  • Easy fracturing
  • Bending of bones
Stem cell information

Osteopenia refers to the early signs and symptoms of weak bones and bone loss which can be linked up to Osteoporosis in the later phase.In another words, a person's bone desinty when checked in Osteopenia, it can be lower than normal, however not low enough to be considered as osteoporosis.

It is also not necessary, that everyone who have osteopenia will be affected with osteoporosis in later stage.With the adaption of healthy life style changes, one can definitely prevent further loss of bones. This can be eating healthy diet high in calcium and fibre, doing regular weight bearing exercises, complete stoppage of smoking and caffeign intake. Any body can be a pray to this disease but some of the possible risk factors, compiled from the available data can be

  • Being Female
  • Having small body stature or being thin
  • Getting too little calcium in diet or diet is full of caffeine
  • Intake of too much carbonated drink
  • Smoking
  • A family history of osteoporosis or osteopenia
  • Heavy alcohol consumption
  • Early menause
Stem cell information

Osteoporosis is the serious bone disorder, happening when there is too much of the bone loss due to soft brittle tissue or there is a little or half formation of bones that are required by the body. Due to excessive brittleness in the bone, bone becomes too weak or it may break due to minor fall. The condition is progressive to the extent that these bones may get affected even from simple actions like sneezing or bumping into the furniture.

The complications associated with osteoporosis can be severe pain and life time deformity. Sometimes it can also be associated with the change in the body posture or complete loss of movement if unattended for a longer period of time. The healthcare professionals directly link up the disease with porous bones, which results in an increased loss of bone mass and strength.

Post Menopausal Osteoporosis

The relationship between the lack of some hormones in the premenopause and menopause have been recently figured out. Usually women after the age of 40 or more experience unnecessary pain, fatigue or low bone density due to major turbulence in estrogen and progesterone level. It is been observed that until the age 30 or latest by 35, a human body is in constant state of bone renewal to compensate for the lost bones. The process of bone renewal is scientifically known as Bone Remodelling. However beyond 40, when women are in their post menopausal phase, this bone renewal is slowed to the extent that the bone resorption is more than it; resulting in a gradual bone decrease in the bone mass. Once this loss of bone reaches certain point, a women is believed to have osteoporosis.

It has been observed that women are at the high risk of developing osteoporosis, as high as four times than men, due to their body structure associated with lighter or thinner bones. Signs & symptoms include:

  • Joint Pain
  • Joint Tenderness
  • Stiffness
  • Loss of Flexibility
  • Grating sensation
  • Bone Spurs
Stem cell information

Rheumatoid Arthritis is a kind of an autoimmune disorder, affecting joints and other areas of the body, causing them to be chronically inflamed. The negligence to it for longer period may lead to deformed and painful joints which are severely malfunctioned. With the passage of time, the disease can also affects other organs such as heart apart from joints.

Although the root cause of the disorder is still unknown, it is known to be inherited i.e. genetically modified disorder, principally involving synovial joints, eventually spreading to the whole body. From a compiled data of research and clinical trials, it has been evident that the disorder is no longer related in any way with the physical or emotional stress of the individual but very well linked with the possibility of genetic alterations in the immune responses. It has been observed that people who have inherited PTPN22 genes from the family background are in the high risk zones.

Apart from genetic, other environmental factors are also found to be associated with the appearance of the disease such as excessive smoking, moderate alcohol consumption or infection with the herpes virus such as Epstein Barr Virus & Human Herpes Virus 6. Vitamin D deficiency is also found to be more common with the people with RA than a generalised population.

In a simpler language, our body expresses two major antibody complexes associated with Rh factor and citrullinated peptides which are being attacked by the T & B lymphocytes, the white cells of our own immune system. This attacking seems to play an important role in the intense inflammatory response present in RA. This again contributes to inflammation of synovium in terms of edema, vasodilation.

Thus considering these facts, some of the commonly associated indications are as follows:

  • Rheumatoid Arthritis resistant to standard treatments
  • Ineffective anti-inflammatory drug therapy including steroids
  • Marked decrease in functional capacity of joints
  • Tropic disturbances of the musculoskeletal system
  • Considerable deviations of immunologic and hematopoietic matters

Arthritis is a complex family of musculoskeletal disorder comprising of more than 100 different conditions that destroy joints, bones, muscles, cartilages and other connective tissues. These in turn cause physical deformities or hamper physical movement.

Lupus is known autoimmune disorder of our immune system. Our immune system runs in a synchronisation of various antibodies and antigens to look after different viruses and bacteria, the body is exposing on a daily basis. These antibodies have a unique ability to recognize self antigens and non self antigens to initiate a proper immune response. But due to genetic modifications, at some point of time our immune system fails to recognize body's internal receptors as our own and attacks them. This event has a serious complications leading to the destruction of our own tissue. This error in the body's immune system is known as "Autoimmune Disorder"

Lupus is a thus an another kind of auto immune disorder altering the immune system of young people and ultimately resulting into swollen joints, red skins, hair loss etc. Although the symptoms associated with the diseases are painful, they do not pose any harm till the time the disease is not spread to the internal critical organs such as heart, brain etc. Thus it is always advisable to counsel the doctor immediately if you come across any of the following indications:

  • A persistent rash across the cheeks and nose in the generalised shape of the butterfly
  • Sun exposed sores, joint pain, fatigue
  • Mouth ulcers on the roof of the mouth
  • Lupus related ulcer appearing on the inner lining of the nose
  • Red, warm, swollen & tender joints
  • Inflammation on the inner lining of the vital tissues such as heart or lungs
  • Observation of microscopic blood cells or proteins that are generally absent in the urine
  • Anxiety, seizures or psychosis

As such there is no cure conventionally for treating Arthritis; besides medications that are there to help relieve the pain temporarily. Anti inflammatory drugs or steroidal medicines are commonly prescribed for all orthopaedic conditions, however it is important to note down that the long term exposure of these medicines can pose other health related complications. In this regard, medical professionals as well as people suffering, were desperately in need of an alternative treatment option, that will help them get out of this trauma.

Stem cells treatment is like a miracle for patients that can help alleviate the pain and inflammation in joints. Stem cells are very naive cells of the body, which can be differentiated to any kind of cells of any kind of origin. This remarkable ability of them has been exploited by the healthcare system to promote regeneration of different damaged tissues, which is the basis of many diseases.

List of diseases treated

Start the online Medical Treatment Evaluation

Stem Cell Treatment

Stem Cell Treatment For Orthopaedic: Advancells Protocol

Here, at Advancells stem cells treatment is offered for Arthritis, by re-infusing back patient's own cells isolated from autologous tissues such as Bone Marrow and/or Adipose Tissue for achieving successful results. This non-surgical procedure reduces joint pain and the need for going through painful Knee replacement surgeries that come with own side effects. Advancells has been effortlessly treating individuals overcome common arthritis and degeneration problems to achieve a better quality of life and health.

These stem cells when injected inside the body, can initiate immune response to facilitate regeneration of new cells that have been lost due to faulty process. Advancells is facilitated by the prodigious prospects of stem cells in treating various diseases, hence we are constantly updating our knowledge and technology to suit unique specifications of each patient. Our principle objective has always been a cessation of disease progress and easing the quality of life to a considerable extent. We are always pledged to deliver safe treatment pattern, by offering "Autologous stem cells from your own Bone Marrow/Adipose Tissue"

Our top priority is to provide very comprehensive, tailor made treatment pattern with the maximum recovery. As a part of our treatment, patient's stem cell are obtained from two sources adipose-derived stem cells (ASCs) and bone marrow-derived stem cells (BMSCs). Sometimes we may use a combination of both, depending upon the assessment.

Step 1- Qualification For The Treatment

A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pretreatment assessments can be suggested depending upon the patient's medical and family background:

Pre-Treatment Assessments

  • Infectious Disease Testing
  • Routine Blood tests
  • Physical Examination
  • X ray

Pre-Operative Procedure

  • MRI
  • CT-Scan
  • Arthroscopy
  • Medical Reports & History

As per these results, the patient will be counseled further for final decision of protocol.

Step 2- Source Extraction

With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolated from Bone Marrow or Adipose Tissue, as these are the most potent autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cell stimulation therapy for some, depending upon the severity and requirement.

The specified amount of samples will be extracted from the patient's own body on the intimated date and time, with the application of local anesthesia. The entire procedure takes around 7-8 hrs, however, in case of extracted from both the sources the patient has to be with us for a little longer time.

If you are curious to know more about the procedure, kindly refer our detailed snapshot below:

stem cell treatment for Orthopaedics

Step 3- Laboratory Processing

The extracted sample, will be sent to the government approved cGMP laboratory for processing. The sample processing will be done in a state of the art class 10,000 clean room in compliance with the ISO and GMP standards.

The sample will undergo minimum manipulation in our complete automated Sepax technology to be enriched with the pure population of stem cell culture. The isolated stem cells will be characterized for quality, purity and viability.

The client will be given a third party certificate from Internationally Accredited Lab for the quality purpose.

Step 4- Stem Cell Implantation

Once stem cells are enriched and ready to be injected back into the body, we have worked on different modes of implanting them. However, depending upon the patient's physiological and mental well being, one of the following will be finalized by our experts.

  • IntraMuscular Injection: - Stem cells will be infused through muscles,to optimize maximum number of cells at the site of injury.

Follow up Treatment

Post treatment, the patient will be asked to visit the doctors for reclamation therapies such as Physiotherapy, patients counselling etc. for accelerated recovery.



Orthopaedic Stem Cell Treatment Results

Ten patients mean age ≥ 45 years (Sex ratio; 2 male: 3 female) with chronic knee pain unresponsive to conservative treatments and radiologic evidence of degenerative arthritis were treated with autologous bone marrow stem cells by intra-articular injection (Read more...)

Patient's Stories

Owen Cooke, 61 years, Osteoarthritis and Foot Damage

"..."Overall, I am very, very pleased with the result so far..."

Malcolm Pasley, Osteoarthritis (Knee)

"...I notice a huge improvement in both knees..."

Robert Da Prato, 64 years, Osteoarthritis - Knees

"...I am happy. Perhaps in a few more months, my situation will improve..."

Wendy Funston, 57 years, Arthritis in Hands, Knees, Feet, Elbows

"...since treatment I HAVE BEEN PAIN FREE!!!!..."



R. Rana, rheumatoid Arthritis Treatment Video
R. Rana, rheumatoid Arthritis Treatment Video
More Video



Frequently Asked Questions

  • What is orthopaedics?
  • Orthopaedics the branch of science, focusing on injuries and diseases of the body's musculoskeletal system; including bones and muscles.
  • What is joint replacement surgery & how long it last?
  • Joint replacement surgery is performed to replace damaged joint with a new, artificial joint known as a Prosthesis. On an average, these joints have a lifespan of 10 years, however it varies depending upon the usage and person's age.
  • What is the difference between the sprain or strain?
  • A strain occurs when the muscle or tendon is stretched or torn. A sprain occurs when a ligament is stretched or torn.
  • What is Sciatica?
  • In our lower back, nerves join to form the Sciatic Nerve; which runs down in the leg and controls the muscles of the leg. Sciatica is the condition that may cause a radiatic pain, numbness, tingling and/or muscle weakness in the leg.
  • What is shoulder impingement?
  • Impingement syndrome, is a common disorder of the shoulder referring to an improper alignment of the bone and the tissues in the upper arm. Inflammatory conditions such as arthritis are closely related to the impingement syndrome.
  • What is the separated shoulder?
  • A shoulder separation occurs when the outer end of the collarbone separates from the end of the shoulder blades because of the torn ligaments. The injury occurs most often from a blow to the shoulders or stretched hand or arms.
  • Do men get osteoporosis?
  • Although osteoporosis is more common in women, atleast one in eight over 50 have the chances of getting osteoporosis. As with the declined testosterone levels in men can also lead to increased chances of the bone loss.
  • How can Osteoporosis be prevented?
  • Osteoporosis can be prevented by reaching the peak bone mass, during the childhood and teenage years. Few habits can be incorporated in order to increase bone mass such as enough calcium and vitamin D uptake by drinking milk and milk products, regular exercise, avoiding milk and milk products, avoiding smoking and excessive alcohol consumption.
  • Can stem cell treatment, reverse my damage?
  • Yes, stem cells are the pristine cells of the body, which can give rise to many different types of cells upon proper signalling. These cells have been exploited successfully to differentiate into neurogenic, osteogenic and chondrogenic lineages. They have been isolated from the very own potent sources of our body known as Bone Marrow and Adipose Tissues. They can be minimally manipulated and implanted back into the body to promote neuroregeneration, bone reconstruction, reformation of tendons and cartilages.
  • Where can I get more information about Disease?
  • Please go through, our treatment brochures for other Orthopaedics related information.


What can you expect?

Many patients after stem cell treatment reported to be exhibiting:

  • Inflammatory process activity decreases
  • Morning stiffness, joint tenderness, oedema is diminished
  • Patient's functional capacity has been improved tremendously
  • Considerable redevelopment of cartilaginous tissue observed from X-Ray analysis that can avoid further damage to the joints.
  • In most of the cases, complete discontinuation or considerable reduction of anti inflammatory drugs has been achieved.
  • Quality of life has been improved in patients achieving 100% target.
  • However, a complete restoration of the central nervous system, is the prolonged process and requires lots of patience and repetition of treatment if required or suggested.

Recent News

Popular Post

View All Post