Stem Cell Therapy for Stroke




A Stroke is considered to be a life-threatening incident, where the brain is deprived of sufficient oxygen. Anyone who has had a stroke in the past or is at risk of stroke should be aware of its treatment and medical care.

The disturbance in the blood supply is either due to Ischemia (lack of blood supply) or haemorrhage (sudden bleeding). It is a kind of attack occurring when a blood clot blocks an artery carrying blood from the heart to the brain (Ischemic Stroke) or a breakage in the blood vessels, interrupting blood flow to an area of the brain (Haemorrhages).When either of these things happen, brain cells begin to die and brain damage occurs. When brain cells die during a stroke, abilities controlled by that area of the brain are lost. These abilities include speech, movement and memory.

The outcome of the strokes depends upon where the stroke occurs and how much is the brain affected; smaller stroke may result in minor problems such as weakness in an arm or leg. A major stroke may lead to paralysis or death.

A normal person can take a stroke as a serious indication of brain damage leading to paralysis, which needs urgent medical attention. However, hardly anyone knows that there are different kinds of strokes which are categorized as per different medical conditions. The four primary types of stroke can be listed as follows:

  • Ischemic Stroke
  • Hemorrhagic Stroke
  • Transient Ischemic Attack
  • Stroke in children

Ischemic Stroke is the most common form of stroke, accounting for about 87% of cases. It is the most dangerous form of atherosclerosis, occurring as a result of an obstruction of fatty deposits within a blood vessel supplying blood to the brain. This underlying condition can cause following two types of obstruction.

Cerebral Thrombosis:- This is the condition,where due to deposition of fatty lining blood vessels can develop a blood clot in the same blood vessels as a major after effect of obstructive blood flow.


Cerebral Embolism:- This is the condition wherein the blood clot is formed at another location in the circulatory system, which can be the heart or other larger arteries of the upper chest and neck. The condition is caused because the portion of the blood clots breaks loose, enters the blood stream and travels through the blood vessels of the brain until it is obstructed by smaller sized blood vessels. A second important cause can be irregular heart beats known as Atrial Fibrillations, a condition wherein clots can be formed inside the heart vessels, dislodge and travel to the brain.


Most of the times, stroke can occur suddenly without warning. However, symptoms may occur on and off for the first day or two. Major Manifestations of stroke, in patients include the following:

  • Abrupt onset of limb deformity
  • Deficiencies related to sensory locomotions
  • Visual loss in one or both the eyes
  • Facial drooping
  • Ataxia
  • Vertigo
  • Sudden decrease in level of consciousness

This is the less common indication of stroke accounting for on an average 13% stroke cases. It is mostly occurring as a result of blood pressure exerted on the blood vessels surrounding the brain tissue. This increased pressure can weaken blood vessel, forcing it to rupture and bleed profusely. Again the condition can be subdivided into two types of stroke, listed as follows:

Aneurysms:- The condition associated with the ballooning of the weakened blood vessel,which, if left untreated for a longer period of time can weaken the vessel until it ruptures and bleeds inside the brain.


Arteriovenous Malformations:- This is the condition giving rise to clusters of abnormally formed blood vessels, if any one of them ruptures it can lead to major blood loss.


The signs and symptoms associated with this kind of stroke are limited to the region of ruptured blood vessels. If the left hemisphere is involved, then the symptoms can be

  • Right side movement deformities
  • Right hemisensory loss
  • Left gaze preference
  • Right visual field cut
  • Aphasia

If the right hemisphere is involved, symptom may involve the following:

  • Left side movement deformities
  • Left hemisensory loss
  • Right gaze preference
  • Left visual field cut

If the haemorrhages are in the sub-arachnoid region, i.e. the area surrounding the brain, then the symptoms may involve the following:

  • Sudden onset of severe headache
  • Signs of meningismus with rigidity
  • Photophobia and pain with the eye movement
  • Nausea and vomiting
  • Syncope i.e. fainting or loss of consciousness for shorter period of time.

Hemorrhagic Versus Ischemic Stroke

Although symptoms alone are not specific enough to distinguish ischemic from hemorrhagic stroke, some of the generalized symptoms such as nausea, vomiting, headache as well as altered level of consciousness are observed to be more common in hemorrhagic stroke and large ischemic stroke, as they indicate intracranial pressure. Additionally, seizures are also more common in hemorrhagic stroke than in ischemic kind. Their occurrence is almost 28% within 24hrs at the onset of the intracerebral hemorrhage

These are ischemic attacks, which can often labelled as mini stroke, and more accurately characterized by warning strokes that needs to be attended very seriously.The difference between the stroke and TIA being, in TIA temporary clots are formed lasting for a relatively shorter period of time. It has been observed that most of these TIA?s can last up to five minutes, the average being about the minute. When the TIA?s are over it usually cause no permanent injury to the brain.


Stroke in children is not as rare as once thought. The risk of stroke from birth through the age 18 has been estimated to be 10.7 per 1,00,000 children per year, and is observed to be the greatest in the first few years of life. Interestingly, the symptoms associated with stroke in children do not mirror that of adult stroke. Even the incidence of their occurrence is different in two main types of stroke, in different adults and children. Seizures are the most commonly occurred early symptoms of stroke in newborn.

Conventionally, surgery was the only option for treating stroke. However, the approach was very painful and the chances of survival were very rare. Thus, medical practitioners were looking for an alternative treatment approach, that can actually ease out the pain associated. With the recent discovery of stem cells, it is now possible to treat stroke patients with their own isolated stem cells. Once dropped inside the body, they can facilitate re-vascularization, remove blood clots. Cells when inserted can promote a cascade of signals to create micro environment that can boost up the process of regeneration.

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Stem Cell Treatment

Stem Cell Treatment For Stroke: Advancells Protocol

Advancells is excited by the prodigious prospects of stem cells in treating various diseases, hence we are constantly updating our knowledge and technology to suit unique specifications of each patient. Our principle objective has always been a cessation of disease progress and easing the quality of life to a considerable extent. We are always pledged to deliver safe treatment pattern, by offering "Autologous stem cells from your own Bone Marrow/Adipose Tissue"

Our top priority is to provide very comprehensive, tailor made treatment pattern with the maximum recovery. As a part of our treatment, patient's stem cell are obtained from two sources adipose-derived stem cells (ASCs) and bone marrow-derived stem cells (BMSCs). Sometimes we may use a combination of both, depending upon the assessment.

Step 1- Qualification For The Treatment

A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pretreatment assessments can be suggested depending upon the patient's medical and family background:

Pre-Treatment Assessments

  • Routine Blood Tests
  • Routine Urine Analysis
  • Infectious Disease Testing
  • Physical Examination
  • X Ray
  • Ultrasound

Pre-Operative Procedure

  • Surgical Correction
  • MRI
  • CT Scan
  • Medical History

As per these results, the patient will be counseled further for final decision of protocol.

Step 2- Source Extraction

With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolated from Bone Marrow or Adipose Tissue, as these are the most potent autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cell stimulation therapy for some, depending upon the severity and requirement.

The specified amount of samples will be extracted from the patient's own body on the intimated date and time, with the application of local anesthesia. The entire procedure takes around 7-8 hrs, however, in case of extracted from both the sources the patient has to be with us for a little longer time.

If you are curious to know more about the procedure, kindly refer our detailed snapshot below:

stem cell treatment for ALS

Step 3- Laboratory Processing

The extracted sample, will be sent to the government approved cGMP laboratory for processing. The sample processing will be done in a state of the art class 10,000 clean room in compliance with the ISO and GMP standards.

The sample will undergo minimum manipulation in our complete automated Sepax technology to be enriched with the pure population of stem cell culture. The isolated stem cells will be characterized for quality, purity and viability.

The client will be given a third party certificate from Internationally Accredited Lab for the quality purpose.

Step 4- Stem Cell Implantation

Once stem cells are enriched and ready to be injected back into the body, we have worked on different modes of implanting them. However, depending upon the patient's physiological and mental well being, one of the following will be finalized by our experts.

  • Intravenous Injection:- Stem cells will be infused into the body, by infusing through the vein.
  • Intra-thecal Injection:- Stem cells will be infused, into the cerebro-spinal fluid of the spinal cord. This route is most popularly known as Lumbar Puncture.
  • Intra-arterial Injections:- Stem cells will be infused through a major artery supplying blood to the targeted area.
  • Surgery:- In case of very rare cases, spinal or brain surgery may be advised for infusing stem cells .

Follow up Treatment

Post treatment, the patient will be asked to visit the doctors after a specific period of time, to understand the medical development through CT-scan, MRI, evaluation etc.



Stroke Stem Cell Treatment Results

Our Stroke treatment objectives have indicated a marked improvement in the degree of paralysis within one year, with improved control over body movements.

The average age of the patients before the stroke treatment was near about 50 years and amongst them, 75% of the patients were male.

The average time between the application of the treatment and the follow-up check was near to 9 months. The patients responded of experiencing effects between eight and nine weeks after the specialized stem cell treatment. 55% of the patients reported of having positive improvements. (Read more...)

Patient's Stories

Damla Uludag, 15 years, Stroke

"...After only 4 days, Damla's spasticity decreased. Her hands were more flexible and less stiff. After a one-week recovery, Damla went back to school again; fully recovered from the surgery...."

Keith Buller, 57 years, Stroke

"...When people ask me about adult stem cell therapy I simply say, "it works"! I am planning to return for another treatment in the next few years...."

Preston Plevretes, 22 years, Stroke & Severe brain injury

"...Preston is walking now; he no longer uses the wheelchair..."

Alvin Mueller, 84 years, Stroke

"...After Stem cell treatment, the feeling in my left arm and leg returned..."

Ton , 63 years, Hemorrhagic Stroke

"...Regaining the ability to speak and walk helped me to return to my old life. I am enjoying it so much and I am very thankful. When I think back to the days in hospital when I thought my struggle was in vain...."

Paul Borgmann, 42 years, Stroke

"...It does not necessarily have to be true if you are told that you will not make any further progress. Do not settle for that - please go and find out about further treatment options with stem cells...."

Click to view or print complete stroke results, including graphs (pdf)



Frequently Asked Questions

  • What should a bystander do during a Stroke?
  • During a stroke, a bystander should know the signs and act accordingly in time. If signs and symptoms of strokes are confirmed, like the person is losing an ability to speak, moving an arm or leg on one side or is experiencing facial paralysis on one side, then support him to avoid any physical injury. Ask someone to arrange for the ambulance as quickly as possible.
  • What does the phrase "time is brain" means?
  • The phrase "time is brain" refers to the fact that the recent treatments to restore blood flow to the brain are effective only if begun within few hours of the onset of stroke.
  • If I have a family history of stroke, am I at a risk of stroke?
  • While hereditary factors play a role in the risk of stroke. There are many things , you can actually incorporate in your lifestyle to help reduce the risk of stroke such as avoiding smoking, excessive alcoholism, improved eating habits, regular exercises etc.
  • Is it true that some people are at a greater risk than others?
  • The chances of stroke increases with the age and genetic make up. Comparatively older people and men are at a greater risk of stroke as compared to their counterparts. People from African
  • and American continents are five times more likely to have stroke as compared to others.
  • How can stem cells treatment help stroke patients?
  • Stem cells are the master cells of the body, which are able to differentiate into variety of cells if channelized properly. Stem cells isolated from autologous body sources such as Bone Marrow or Adipose Tissue are observed to be superior in vascularization i.e. formation of new blood vessels, clearing obstructed blood flow and regenerating dead cells. Various clinical trials have shown good improvements in patients.
  • If I had stroke attack earlier, can I still opt for the stem cells treatment?
  • Although, sooner is the better but depending upon the physical evaluations, doctors can tell you the best possible way through which you can avail this treatment.
  • Where can I get more information about Disease?
  • Please go through, our treatment brochures for other Stroke related information.


What can you expect?

Many patients after stem cell treatment reported to be exhibiting:

  • Regained their independence
  • Controlling risky conditions such as seizures, spasticity and paresis
  • Improved physical and mental balance
  • Improved self regulation
  • Improved quality of life
  • Complete stoppage or progression of the disease

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