Amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease is a severe neurodegenerative disorder where progressive degeneration of motor neurons occurs.

Symptoms of ALS

ALS has varied symptoms, which differ from one person to another. In most of the cases ALS affects the regular activities of the individuals. The onset of ALS is quite subtle and thus the symptoms remain either overlooked or misread. At the beginning of ALS there are only mild symptoms. The most common initial symptom of ALS includes progressive, painless muscle weakness. There are several early signs of ALS, which should not be ignored by people.

Ten early signs of ALS include the following:

  1. Muscle cramps and muscle stiffness (spasticity) – are the most common symptom of ALS. There are variations in the frequency and the severity of the cramps among the ALS patients; few patients experience frequent cramps, while some experience less frequent cramps. The prevalence of cramps has been found to be constant from diagnosis till later stages of ALS.
  2. Weakness of muscles– The muscles of arms, legs, neck, and diaphragm become weak and soft as there is muscle atrophy thus leading to a problem with balancing.
  3. Fasciculation or muscle twitches –are a common symptom of ALS. These persistent muscle twitches mostly involve the muscles ofthe arm, shoulder, leg, and tongue and occur due to ongoing disruption of signals from the nerves to the muscles. Fasciculation is usually not painful but irritating and disrupts the sleep cycle of the patients.
  4.  Hand weakness– The most common early symptom of ALS is a painless weakness in handsleading to difficulty in grip and a tendency to drop things. Thus the individualsface difficulty in lifting a pen when writing, buttoning a shirt, turning a key into a lock, lifting or holding a coffee cup etc.
  5. Weakness in leg– This occurs in ALS patients due to weakening of the leg muscles. This creates a problem with balancing, leading to tripping or staggering while walking or running.
  6. Fatigue- The relentless progression of the disease causes generalized weakness with loss of movements, decreased endurance and functionality, and also reduced ability to perform normal everyday activities. Fatigue can occur due to different reasons including muscular alterations, reduced physical resistance etc.
  7. Speech problem- This occurs when bulbar neurons are affected. In some ALS patients, muscles of tongue, lips, vocal cords, and chest undergo atrophy. Thus, the individuals have speaking difficulties also known as ‘dysarthria’. This condition is characterized by slow, effortful, and slurrednasal speech.
  8. Problem with chewing or swallowing- This is a common condition in ALS that occurs due to weakening of the throat and mouth muscles, as a result there is a risk of excessive choking while eating.
  9. Breathing problem- When the muscles involved in breathing weaken, a person faces difficulty to inhale or exhale and take shorter and shallower breaths. Shortness of breath occurs during vigorous physical activities like running, walking long distances, climbing stairs, or exercising. The individual thus gets tired quickly and develops headache and also undergoes restless sleep.
  10.  Uncontrolled crying or laughter Spells of uncontrolled laughter and crying is well known in ALS patients. These emotional spells typically occur due to the involvement of bulbar neurons in ALS patients and show disparity between the patient’s emotional expression and his or her emotional experience.

Connect with Advancells at, and you can also give us a call on +91-9654321400 for your inquiries, Stay In Touch.