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Erectile dysfunction was recommended by some experts in 1992 to replace the term “impotence”. Erectile dysfunction is defined as the inability of getting and maintaining a penile erection, thus affecting sexual performance and interest. Erectile dysfunction or ED is not a life-threatening disease but aside from psychological harm, it is a strong risk factor of cardiovascular diseases and other metabolic diseases. Conventional medication for ED has been shown to become ineffective or cause side effects in several patients. Therefore, many doctors are turning towards alternative treatments like stem cell therapy.

What is Erectile Dysfunction?

In 1995, the global prevalence of erectile dysfunction was 152 million and this number is supposed to reach a whopping 322 million by 2025 (Ref: https://bit.ly/3dctNlC). The main symptoms of ED are reduced sexual interest, stress, Inability to gain an erection, and fatigue.ED can cause physical ailments as well as mental problems. While health ailments include unregulated blood pressure, heart disease, high cholesterol, and high blood pressure, psychological problems usually concern depression and anxiety.

Why are Doctors Turning to Stem Cell therapy for ED Treatment?

The potential treatment regime for ED includes medications, pumps, implants, and counseling. ED medications include drugs like Viagra or Levitra that stimulate blood flow in the penile region whereas penile pumps aim to achieve a similar function using the vacuum pressure concept. As for surgeries or implants, they are used to implant malleable rods to achieve an erection but pose a significant risk of penile tissue scarring. The above-discussed treatments come with their own share of side effects and risks and therefore, alternative treatments like stem cell therapy have been coming up in recent years as a preferrable mode of ED treatment.

Published Reports of Stem Cells in ED Treatment

Embryonic stem cells have been used in ED studies and the main challenge was establishing a proper embryonic stem cell culture earlier (Ref: https://bit.ly/3qrvQr6) but owing to the ethical concerns and the emergence of mesenchymal stem cells as a better ethical and safe alternative, researchers focused more on mesenchymal stem cells.

Mesenchymal stem cells were first isolated from bone marrow and other sources like adipose tissue and umbilical cord started coming up. Earlier studies of ED in animal models used allogenic or xenogeneic bone marrow-derived stem cells but similar applications in the case of humans raised immunocompatibility issues, and therefore further processing and trials of autologous bone marrow stem cells in ED were planned by researchers. (Ref:https://bit.ly/3jdSyS0). In some studies, bone marrow mono nuclear cells were used to treat ED in animal models (Ref: https://bit.ly/3ddPaD4) but critics are of the opinion that specific mononuclear cells were not characterized in those studies and thus cannot be significantly addressed for therapeutic potential.

Aside from bone marrow stem cells, umbilical cord blood stem cells have been used for ED treatment in a clinical study (Ref: https://bit.ly/2Uthafi) and to be specific, researchers claim that mesenchymal stem cells have been used in the study. The most common stem cell types that are being used for ED treatment are adipose-derived mesenchymal stem cells. These stem cells have proven their therapy efficiency in several other disorders like arthritis and also hold the advantage of an abundant tissue source. Along with adipose-derived stem cells, stromal vascular fraction cells have also been used in ED therapeutics (Ref: https://bit.ly/3gUJBvz).

Stem cell therapy advancements in erectile dysfunction has been a scientific ride for the clinical researchers and several significant improvements, in the form of healed penile blood-vessel injury and better erection, have been seen in erectile dysfunction patients upon undergoing mesenchymal stem cell therapy. If you are looking for stem cell therapy consultation for erectile dysfunction, contact ADVANCELLS at info@advancells.com

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