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Stem Cell Therapy For ALS Or MND

The Science Of Regenerative Medicine: Unleashed

With a deeper understanding of biology underlying ALS; we are accelerating curative therapies.

Our treatment protocols are tailored for each and every person.

Stem Cell Therapy for Motor Neuron Disease

We are ready with our advanced secretome tool to combat innate and adaptive immune responses and other abnormal immune system alterations evident in Motor Neuron Disease

Amyotrophic Lateral Sclerosis (ALS), also commonly known as Motor Neuron Disease (MND) is a fatal neurodegenerative condition; characterized by progressive damage to involuntary muscular movements. Today, 2-3 people after every 1,00,000 individuals are suffering from ALS/MND in totality. People, suffering from ALS can face challenges in performing multiple tasks like swallowing, chewing, speaking, short-term memory, etc. Progressively the person can go fully bedridden with issues related to breathing, bladder and bowel control, grade III artificial lung ventilation, dysphasia; making life more painful. Unfortunately, conventional medical treatment can only offer rehabilitation and steroidal medicine as a last resort for symptomatic management; and the improvements with them so far are very disappointing (Mitsumoto H; et.al 2009). With the advent of novel technology in regenerative medicine, the promising potential of stem cells can be utilized to stop and regenerate lost neurons and neuromuscular connections (Kim H, et.al; 2010). Several clinical studies conducted worldwide using different types of adult stem cells have confirmed the delay in ALS/MND progression; if treated at a very early stage of the disease (Karumbayaram S, et.al; 2009). Advancells is proud to offer Exosomes along with Stem cells for reduced inflammation and a better regeneration. The exosomes are the smallest part of EVs with the ability to cross the blood-brain barrier (BBB) and are potential cell-free candidates to stimulate resident neurons for better regeneration (Ciregia F., et.al; 2017).

Stem Cells Therapy For ALS: Advancells Protocol

With years of expertise, Advancells has come up with an exclusive stem cell treatment protocol to manage fatal, progressive degenerative diseases like Motor Neuron Disease. We have developed different types of stem cells suitable for different applications. With each dose of stem cells, we are providing exosomes therapy. Recent scientific research has revealed that the healing power of stem cells is enhanced in a true sense with the help of exosomes. They are a group of paracrine factors secreted by mesenchymal stem cells; which act as messengers between the cells to promote faster tissue repair and healing through anti-inflammation.

At Advancells, we endeavor to improve the health and well-being of those we serve with a commitment to scientific excellence, advanced technical support, and a competent quality management system.

The procedure of MND Treatment with Stem Cell Therapy

Treatment Qualification
Source Extraction
Processing of stem cells
Re-infusion
ALS, the fatal neurodegenerative condition can strike at any age; however, data collected so far specifically emphasize 55 to 75 years as the average age of diagnosis. Studies have confirmed that depending upon the type of motor neurons affected, the motor neuron disease can further be classified as
Difficulty walking
Slurry speech
Difficulty swallowing
Drooling
Frequent muscle cramps, muscle spasticity.
Twitching in arms, shoulders, and tongue
This is the most common form of Motor Neuron Disease, named after the baseball player Mr. Lou Gehrig; who was by far the most famous person of his time to develop MND.
Weakness in legs
Unusual tripping
Stiffness associated with spasticity
Intermittent muscle spasm
Urinary incontinence
Unusual fatigue
Central lateral Neurosis, also known as Primary Lateral Neurosis is a rare degenerative disorder of upper motor neurons, mainly affecting central motor neurons. This is a slowly progressive disorder and generally, degeneration may begin with one leg; gradually affecting both legs and arms. (icons ke niche)
Slurry nasal speech
Weakness in hands
Frequent episodes of neck stiffness
Difficulty in chewing and/or swallowing
Frequent episodes of shortness of breath
Fasciculation
This is another form of motor neuron disease, mainly affecting lower motor neurons responsible for chewing, swallowing, etc. The course of illness and the fatal prognosis is similar to that of Amyotrophic Lateral Sclerosis.
Shaky hands and legs
Frequent muscle cramps and twitches
Weakness in the face, arms, and legs
Enlarged breasts in men
Early-onset of Erectile Dysfunction
Difficulty in holding
Kennedy disease, also known as spinobulbar muscular dystrophy is a rare form of motor neuron disease, affecting only men; while females can be carriers. The symptomatic exhibition of Kennedy disease, unfortunately, starts at a very early stage; as early as 30 years of age.
Muscle weakness in fingers and hands
Muscle twitching, fasciculation, twitching
Decreased arm strength
Frequent episodes of spine stiffness
Intermittent muscle spasm
Drooling
Monomeric Amyotrophy, also known as Hirayama Disease or Juvenile muscular atrophy is another rare form of motor neuron disease affecting muscles of the upper extremities including the spinal cord. This form of MND is mostly reported in young males; between the age group of 14-25 years.
Motor Neuron Disease is an uncommon neurodegenerative condition, primarily affecting motor neurons involved in muscular movements. Studies have correlated different lifestyle-related, genetis as well as epigenetic factors to be responsible for its onset. Statistics have confirmed its prevalence in people in the age group of 60-70 years; however, a certain form of MND can affect humans of all age groups.

CAUSES OF
ALS
  • Certain viral infections may hijack connections between brain cells and muscles causing acute flaccid paralysis; such as poliovirus
  • Long term exposure to certain chemicals and/or toxins
  • Genetic predisposition
  • The inflammatory response triggered due to a faulty autoimmune mechanism
  • Lack of secretion of neurogenic growth factors, degeneration, aging of motor neurons
  • Brain hypoxia, ischemia, stroke, unusual mental and/or physical stress, repeated head injuries
  • Other triggers include certain types of cancer and environmental contaminants

“Motor Neuron Disease, a group of neurodegenerative disorders is incurable with conventional medicine; but certainly manageable with the help of regenerative medicine. ”

Certain rehabilitative approaches are suggested along with stem cells to stimulate muscle power, reduce disease progression and help patients perform their day-to-day tasks independently for a prolonged period.
Occupational Therapy It effectively helps children to work on physical, motor and cognitive skills. The goal is to achieve control over everyday skills by becoming more independent and involving active participation. It can also help strategize sensory issues post stem cell therapy.
Hyperbaric Oxygen TherapyIt provides a higher concentration of oxygen delivered in a chamber with higher atmospheric pressure. The condition initiates hypoxia in the brain to facilitate improved oxygenated blood flow towards the brain, hence indirectly improving the flow of stem cells towards the target.
Speech TherapyIt addresses challenges with language and communication. It helps children with autism to improve verbal, non-verbal and social communication. The goal is to help children improve communication skills in more functional ways.
Sensory IntegrationThe therapy is specifically designed to enhance processing skills of sensory information; such as textures, sounds, smell, taste, brightness etc. With the rationale of understanding how information is being processed in their brain, children are helped to make better sense of information that can be used in doing multiple tasks on a daily basis.
Dietary ModificationFor some children with autism, certain dietary changes have reportedly produced dramatic differences in the symptomatic exhibition and functional improvements. With good scientific investigation, experts believe that children with autism are to be evaluated for certain dietary modifications, either in combination or alone; in order to evaluate significant functional improvement in the brain.
Psychological InterventionsIt aims at shaping behavioural issues using classic and/or instrumental conditioning. It is designed with objectives to focus mainly on core deficits associated with mental issues or psychological challenges reported in the spectrum.

Research has emphasized that adult stem cell therapy is absolutely safe form of treatment; although a lot of clinical development and refinement are on the way. The outcome obtained from clinical studies is remarkably positive and motivating. With rigorous data analysis, we propose a reversal and multimodal treatment showing clinical improvements in Autism through stem cell therapy.

Worldwide Clinical Studies using Stem Cells obtained from different sources

70% people have reported increased survival functions on an average with 87.76 months

With the help of our comprehensive environment and advanced technologies, we believe in building trust and transparency with our patients. So far, we have provided stem cell therapy for ALS/MND to a number of patients and their clinical improvements have been amazing. Check out some of our patient testimonials:

TYPES OF MND

Difficulty walking
Difficulty walking

Slurry speech
Slurry speech

difficulty swallowing
Difficulty swallowing

drooling
Drooling

Frequent muscle cramps, muscle spasticity
Frequent muscle cramps, muscle spasticity.

Twitching in arms, shoulders, and tongue
Twitching in arms, shoulders, and tongue


Weakness in legs
Weakness in legs

Unusual tripping
Unusual tripping

Stiffness associated with spasticity
Stiffness associated with spasticity

High-pitched or flat voice
Intermittent muscle spasm

Difficulty with transitions
Urinary incontinence

Repetitive behaviours
Unusual fatigue


Slurry nasal speech
Slurry nasal speech

Weakness in hands
Weakness in hands

Frequent episodes of neck stiffness
Frequent episodes of neck stiffness

Difficulty in chewing and/or swallowing
Difficulty in chewing and/or swallowing

Frequent episodes of shortness of breath
Frequent episodes of shortness of breath

Fasciculation
Fasciculation


Shaky hands and legs
Shaky hands and legs

Frequent muscle cramps and twitches
Frequent muscle cramps and twitches

Weakness in the face, arms, and legs
Weakness in the face, arms, and legs

Enlarged breasts in men
Enlarged breasts in men

Early-onset of Erectile Dysfunction
Early-onset of Erectile Dysfunction

Difficulty in holding
Difficulty in holding


Limited facial expressions
Muscle weakness in fingers and hands

Muscle twitching, fasciculation, twitching
Muscle twitching, fasciculation, twitching

Decreased arm strength
Decreased arm strength

Frequent episodes of spine stiffness
Frequent episodes of spine stiffness

Intermittent muscle spasm
Intermittent muscle spasm

Drooling
Drooling

CAUSES OF MND
Motor Neuron Disease is an uncommon neurodegenerative condition, primarily affecting motor neurons involved in muscular movements. Studies have correlated different lifestyle-related, genetic as well as epigenetic factors to be responsible for its onset. Statistics have confirmed its prevalence in people in the age group of 60-70 years; however, a certain form of MND can affect humans of all age groups.

  • Certain viral infections may hijack connections between brain cells and muscles causing acute flaccid paralysis; such as poliovirus.
  • Long term exposure to certain chemicals and/or toxins
  • Genetic predisposition
  • The inflammatory response triggered due to a faulty autoimmune mechanism
  • Lack of secretion of neurogenic growth factors, degeneration, aging of motor neurons
  • Brain hypoxia, ischemia, stroke, unusual mental and/or physical stress, repeated head injuries
  • Other triggers include certain types of cancer and environmental contaminants
SUPPORTIVE THERAPY

“Motor Neuron Disease, a group of neurodegenerative disorders is incurable with conventional medicine; but certainly manageable with the help of regenerative medicine.”

Certain rehabilitative approaches are suggested along with stem cells to stimulate muscle power, reduce disease progression and help patients perform their day-to-day tasks independently for a prolonged period.

Occupational Therapy
Occupational Therapy

Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy

Speech Therapy
Speech Therapy

Sensory Integration
Sensory Integration
Dietary Modification
Dietary Modification

Psychological Interventions
Psychological Interventions

IMPROVEMENTS

Research has emphasized that adult stem cell therapy is absolutely safe form of treatment; although a lot of clinical development and refinement are on the way. The outcome obtained from clinical studies is remarkably positive and motivating. With rigorous data analysis, we propose a reversal and multimodal treatment showing clinical improvements in Autism through stem cell therapy.

Worldwide Clinical Studies using Stem Cells obtained from different sources

Improvement in clinical signs and symptoms
ALS TESTIMONIAL

With the help of our comprehensive environment and advanced technologies, we believe in building trust and transparency with our patients. So far, we have provided stem cell therapy for ALS/MND to a number of patients and their clinical improvements have been amazing. Check out some of our patient testimonials:

Must Read Articles On ALS Or MND

Early Symptoms of Motor Neuron Disease
Early Symptoms of Motor Neuron Disease

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Statistics Of Overall Improvement of Motor Neuron Disease Using Stem Cell Therapy

Data obtained from clinical and preclinical analysis abounds that the regenerative potential of stem cells holds great therapeutic potential for fatal diseases like Motor Neuron Disease. Scientists are working continuously to obtain substantial evidence to guide practice on the use of stem cells to treat ALS/MND; due to defined regulatory protocols. However, the safety and efficacy of mesenchymal stem cells obtained from various sources like Bone Marrow, Adipose Tissue, etc. have already been evaluated. The data further suggests that the appropriate source of cells, phenotypic determination, a dose of stem cells, and the mode of delivery of cells in the body are the key elements that decide the fate of stem cells and the clinical outcome of patients.

Accordingly, Advancells is implementing the best possible approach to prevent or minimize the neurological deficit in ALS/MND; and to prolong survival in this fatal condition. A detailed treatment plan including cost for stem cell therapy for multi-stage MND shall depend upon the clinical review of patient by expert neurologists.

FAQs

 
Advancells is a strong advocate of greater transparency in medical procedures in general and Stem Cells Procedures in particular. As a part of our effort of bringing transparent procedures to our clients, we provide each client a Third Party Certificate (from an internationally accredited lab) for the cell count and viability of the cells that we are able to process from the autologous cell source of the patient. To view the sample copy of the certificate  click here

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