January 13, 2017

Stemming Up with Diabetes-The targeted approach of curing so called “sugar disease” with stem cells therapy has proven to be the best available cure; with relatively simple, yet well understood mechanism, without any possible risk factors exposed. Scientists have toiled for years, to find out different ways to isolate stem cells outside the body and infuse them back, in order to achieve successful reprogramming of the body; following multiple failures, the headline grabbing results are now been evident, as a stem cells breakthrough for many high profile diseases, such as diabetes.

Diabetes has been identified as a critical health issue for people in the 21st century. According to the number published through International Diabetes Federation, 7 % of the world population, i.e. almost 300 million people are suffering with the disease currently. The statistical analyses as well suggest that increased adaptation to “on the go” sedentary lifestyle, flexibility to dangerous addictions, and ageing population can be listed out as some of the important causes of diabetes prevalence. Moreover, it is imposing a major economic burden on the society due to its dangerous link ups with cardiovascular disorders, kidney problems, etc. In spite of extending such an enormous medico economic burden; it is quite frustrating to state that conventional medical treatments can only manage the disease with the help of steroidal medications, insulin shots as well as nutritional advice. However, very few general people know that the long term exposure to these medications can be very harmful, encouraging many opportunistic infections due to unregulated immunity.

Stemming Up with Diabetes

Diabetes apparently is defined as the body’s inability to regularize insulin production, which facilitates the glucose transportation at the cellular level. The uncontrolled production of insulin is an indication of progressive beta cell death. As a matter of fact, conventional medications as well as diet and exercise can never be effective at the cellular level, in order to channelize the production of pancreatic beta cells. Alternative to this, stem cells and their therapeutic role in order to regularize body’s own immunity against the self destruction of insulin producing cells has shown visionary path ahead in treating diabetes.

Stem cells are the basic cells of our body with the ability to differentiate into multiple cell lineages, if activated through proper signaling pathways. Our body has many stock reserves of adult tissue specific cells, which can remain dormant throughout the life of an individual, if not used by the host organ for its normal wear and tear. Likewise, adipose tissue and bone marrow are two of the richest adult tissue sources with abundant reserve quota of stem cells, which will be wasted, if not utilized for the good cause. Scientists worldwide proved the potential of stem cells isolated from these mentioned autologous sources at the bench side. The laboratory studies have further confirmed that stem cells can smartly enhance bonafide production of pancreatic beta cells, if infused at the targeted site of injury. The strong networking ability of these stem cells can provoke enhanced signaling effects, connecting them with various stem cells present in different organs. These networking can facilitate a strong reinforcement of stem cells from different origins to initiate a cascade of signals for the prompt regeneration of lost cells, creation of suitable microenvironment and production of immunoregulatory antibodies to structure body’s immune system and reduce further deterioration of pancreatic beta cells. Increased production can further enhance the production of hormone insulin to initialize glucose transportation.

Thus, research and ongoing clinical trials on diabetes treatment using stem cells therapy have strongly supported the immuno modulation to reduce destruction of pancreatic beta cells; thus further endorsing stem cells to be the frontier for diabetes treatment.

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