Treatment for Parkinson in India- Parkinson’s treatment is possible by Stem Cells and this technology is showing promising results. Know more about the Parkinson disease treatment by stem cells. If you are in search for best stem cell treatment in India, then you have visited right platform. Parkinson’s is a degenerative disorder of the brain that because of the incapability of the body to produce dopamine which leads to shaking (tremors) and difficulty with walking, movement, and coordination. Dopamine is a neurotransmitter or a chemical messenger that enables a person to control all muscular movements of the body. When this dopamine production is interrupted and signals cannot be transmitted properly from the brain, then the body’s motor function is affected.
Signs and Symptoms:
Symptoms may affect one or both sides of the body, and can include:
- Slow blinking (tremors involving half of the body)
- Difficulty swallowing
- Problems with balance and walking
- No expression in the face (like you are wearing a mask)
The cause of Parkinson’s disease is unknown, but several factors appear to play a role, including:
- Your genes: Specific genetic mutations can cause Parkinson’s disease
- Environmental triggers: The risk of getting Parkinson’s disease increases with the exposure to certain toxins or environmental factors.
Risk factors for Parkinson’s disease include Age (usually develop in older people of more than 60 years of age), Heredity (Close relative with Parkinson’s disease), sex (more likely to occur in males) and exposure to toxins (herbicides and pesticides).
Treatment for Parkinson:
Conventionally, there was no cure available for Parkinson’s. Until recently people have been unaware with the existence of such kind of a disease, which alters your muscular movement as well affects some of the non-motor functions such as a sense of smell or the sleep regulation, etc. Medications can only help in relieving the symptoms of the disease and for certain cases, surgery is done to regulate certain regions of your brain and improve your symptoms.
Medications increase the brain’s supply of dopamine which heals in managing the problems with walking, movement and tremor. But directly ingesting or taking dopamine will not help as it is unable to enter your brain. Various Parkinson drugs are used for the symptomatic relief to the patient:
- Levodopa: It is a natural chemical that passes through your brain and is converted to dopamine, thus considered as the most effective Parkinson’s disease medication. A combination of Levodopa with carbidopa is mostly used as carbidopa protects levodopa from premature conversion to dopamine outside the brain and subsides the feeling of nausea. Levodopa side effects include confusion, delusions and hallucinations.
- Dopamine agonists: these drugs aren’t changed into dopamine. Instead, they mimic the effects of dopamine in the brain and cause neurons to react as though dopamine is present. They are not nearly as effective in treating the symptoms of Parkinson’s disease. However, they last longer and are often used to smooth the sometimes off-and-on effect of levodopa.
- MOA B inhibitors: By inhibiting the activity of the enzyme monoamine oxidase, these drugs prevent the breakdown of dopamine (naturally occurring as well as formed from levodopa). E.g. Selegiline and Rasagiline. Side effects are rare but can include serious interactions with other medications.
- Catechol O-methyltransferase inhibitors prolong the effect of levodopa therapy by blocking an enzyme that breaks down dopamine. Eg. Entacapone.
- Side effects include an increased risk of involuntary movements, diarrhoea or other enhanced levodopa side effects.
- Anticholinergics: help control the tremor associated with Parkinson’s disease. Eg benztropine and trihexyphenidyl.
Deep brain stimulation (DBS): An electrode is implanted deep within the parts of your brain that control the function of movement. A pacemaker-like device controls the amount of stimulation delivered by the electrode and this device is placed under the skin in your upper chest.
Deep brain stimulation is most often used for people who have advanced Parkinson’s disease and have unstable medication (levodopa) responses. It can stabilize medication fluctuations and reduce or eliminate involuntary movements. As DBS cannot keep Parkinson’s disease from progressing and provides relief from the symptoms only, it is not a long term treatment for Parkinson’s.
THERAPIES FOR PARKINSON’S
Physical and Occupational Therapy
Physical therapy may be advisable and can help improve mobility, the range of motion and muscle tone. Along with this lifestyle changes, healthy eating (high fibre rich food), regular exercise, avoiding falls as Parkinson’s disease affects the balance and coordination, walking with care and daily life activities need to be addressed with the help of an occupational therapist. Occupational therapy also aids in arm and hand therapy, handwriting, dressing and grooming and bathtub and toilet equipment use.
A speech pathologist or speech therapist helps in understanding the techniques of communication as difficulty in speaking and swallowing can be severely limiting symptoms of Parkinson’s disease
Alternative Parkinson Treatment Options:
Increasing the consumption of Vitamin E, coenzyme Q10, and uric acid can help in alleviating the symptoms of Parkinson’s disease.
STEM CELL TREATMENT FOR PARKINSON
Several studies taking place worldwide have indicated that stem cells can be the right candidate to alter the progression as the current Parkinson disease treatment options have been proven to be very dangerous, posing many health hazards on the patients.
Stem cells are highly specific biological cells which have the capacity to differentiate and regenerate into specialized cell types. These can be extracted from the bone marrow and adipose tissue which can provide an abundant supply of stem cells and thus considered to be the most potent and opted choice of stem cell suppliers. Stem cell therapy is the treatment using stem cells which are able to cure or repair the damaged tissues in a severe health condition. Stem cells have the great potential in the treatment of conditions with neuropathic pain. Bone marrow or adipose-derived stem cells differentiated into glial-like cells express a range of neurotrophic factors, which provides neuro-protection and neuro-regenerative effects. Critical in providing a protective microenvironment, neurotrophic factors are growth factors known to promote neuron development and survival. They also maintain functional integrity, promote regeneration, regulate neuronal plasticity, and regulate secretion of dopamine and aid in the repairing of damaged nerves.
In the Parkinson treatment with stem cells, the focus remains on delivering the sufficient number of Adult Autologous Stem Cells extracted from one’s own bone marrow or adipose tissue to the injured area for better healing and regeneration of the desired nerve cells. In bone marrow, the stem cells are extracted from hip bone or iliac crest after general anaesthesia and in adipose tissue, the extraction is done from belly area with local anaesthesia. The extracted cells are processed to be enriched with the pure line of stem cells and re-injected into the patient either by intravenous (infusion through the vein) or intrathecal (infusion through lumbar puncture) injections. Post-treatment, the patient is asked to visit the doctor after a specific period of time for some rehabilitation programs, including analysis of the recovery of motor, sensory and bodily functions of the patients.
The current stem cell treatment benefits are already well documented like speeding up healing time, lowering chronic pain, reducing the need for medications, increasing functionality, decreasing nerve damage and improving collagen concentrations and it is expected that continued research will pave the way for new treatments. Stem cell therapy is a miraculous ray of hope for those suffering from serious diseases, as it can help in the reversal of the disease. Still, a lot needs to be explored to utilize the full potential of stem cell therapies and continued research should teach us more about using stem cells to treat devastating medical conditions like Parkinson’s.
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