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Autism is a neurological condition that lasts a lifetime and has a spectrum of symptoms. Social interaction problems, communication difficulties, and the appearance of repetitive or stereotyped groups of behaviour and interests are some of the characteristics of the disorder. Genetic and environmental factors that are still unclear complicate the aetiology of autism. However, over the past ten years, the epidemiology of autism spectrum disorder (ASD) has significantly increased.
The invention of novel biomarkers and pharmacotherapies is required due to the rise in the prevalence of autism spectrum disorder.

ASD is thought to be caused by neuroinflammation and dysregulation of the neuro-immune bridge, inferring that stem cell therapy could be used to manage the disorder. You might go through the blog to learn more about how exosomes from stem cells are used to manage autism.

Stem Cell-Derived Exosomes

The therapeutic effects of stem cells may be mediated via exosomes released by stem cells. Recent developments in stem cell therapy have offered autistic individuals hope. For instance, mesenchymal stem cell (MSC) therapy has been shown to be beneficial in alleviating the symptoms of autism spectrum disorder in clinical investigations.

Due to their ability to control regeneration processes within our bodies, exosomes may be helpful in the treatment of individuals with autoimmune disorders, chronic inflammation, and other chronic degenerative conditions. At least some of the therapeutic success may be attributed to exosomes’ anti-inflammatory properties. The ability of exosomes to cross the blood-brain barrier (BBB) and promote neuronal differentiation and development while inhibiting inflammatory pathways in the neural tissue may be the reason for this.

The therapeutic efficacy of exosome therapy suggests a potential method for managing neurological impairments, including autism spectrum disorder, as a cell-free therapy to alleviate autism-related symptoms.

Expected Outcomes with Stem Cell Exosome Therapy

Due to the lack of a specific biological marker for autism, the disorder is identified in the early years of life by observing behaviour. However, the use of exosome therapy for autism has been made possible by the genetic and biochemical changes that explain the disorder. Their effects on nearby cells and their immunomodulatory activities, in particular, have paved the way for useful applications in the treatment of autism.

Exosomes, which stem cells produce and release, have a wide range of effects on different cell types and may activate endogenous repair pathways in injured organs, restoring their functionality. Exosome cargo can be delivered to recipient cells in order to restore certain biochemical pathways that have been harmed by autism. Exosomes also have anti-inflammatory effects on neurological disorders, most probably as a result of their ability to promote the production of anti-inflammatory cytokines. Their application in reducing the elevated pro-inflammatory state linked to ASD may be advantageous in this aspect.

Some of the expected results of exosome therapy for autism might include:

  • kids are more likely to maintain their eye contact.
  • greater attentiveness, especially to directions, rules, and expectations from parents; reduced hyperactivity; fewer small obsessions; less repetitive behaviour; and more appropriate behaviour at home and outside.
  • improved verbal communication: Even pre-verbal kids have a propensity to begin exploring sounds and phrases.
  • enhanced learning capacity, concentration, and attention span. Their writing skills improve or develop.

Exosomes made by stem cells can travel to and nestle in on specific targeted brain regions. Similar to stem cell localization, which occurs when stem cells move toward the injury site in accordance with the local chemical environment, this property appears to be similar to exosomes. Additionally, this trait is important for potential autism therapy because autistic kids have decreased BBB integrity.

If you want to know more about exosome therapy for autism, reach out to us info@advancells.com or call us at +91-9654321400