Stem cell treatment for diabetic foot-Diabetes can be one of the common diseases, affecting the body’s ability to produce or use insulin, a hormone that allows your body to turn glucose into energy. Although diabetes can be effectively managed, its impending complications include heart disease, stroke, and chronic kidney damage; which are hard to cure. Diabetic patient usually feels a sense of loss, fear, stress, anger, shock, guilt and disbelief and not wanting to think about it.
Your body will digest the food that has been consumed by you and release sugar molecules in your blood stream. These sugar molecules will be utilized by different cells to fulfill their daily energy requirements. Hormone insulin produced in the pancreas can help in accomplishment of the transportation of glucose molecules from blood stream to the cells. In a person with diabetes (diabetes mellitus), the pancreas either produces too little insulin, or the insulin that has been produced cannot be utilized. This allows blood glucose levels to rise, while the rest of your cells are deprived of much needed energy; leading to a wide variety of problems affecting almost every part of your body.
While diabetes may lead to mechanical changes in conformation of the bony architecture of the foot, peripheral neuropathy and other peripheral arterial diseases; due to which the flow of blood towards the wound will be restricted to a great extent, with more chances of infection. Restricted blood flow can cause loss of protective sensation, and lack of muscular coordination, causing an increased mechanical stress, leading to amputation. Although, it is very essential to manage your diabetes and maintain a healthy lifestyle, which eventually keeps your feet healthy, this is advised to inspect your feet every day, and seek care early, if you do get a foot injury. Make sure your health care specialist checks your feet at least once a year; more often if you have foot problems.
Most people can prevent any serious types of foot ulcers by following some simple steps.
- Remember to take off your socks and shoes while you wait for your physical examination.
- Call or see your health care provider if you have cuts or breaks in the skin, or have an ingrown nail. Also, tell your health care provider if your foot changes color, shape, or just feels different (for example, becomes less sensitive or hurts).
- The feet should be washed and dried at least once a day. It is important to dry the inter-digital spaces between the toes very carefully.
- The diabetic patients, especially the ones with sensory neuropathy, should not use the heating pads over their bodies. It is also recommended to warn the patient not to place their feet close to the heaters during the winter.
Successful treatment of diabetic foot ulcers is hindered by the lack of targeted therapy that hones in on the healing processes deregulated by diabetes. Stem cells are a promising treatment for DFUs as they are capable of targeting, as well as bypassing, the underlying abnormal healing mechanisms and deranged cell signaling in diabetic wounds and promote healing. This review will focus on existing stem cell technologies and their application in the treatment of DFUs.