Over the years, while we grow, the bones in our body constantly dissolve and rebuild their matrix in a process called remodeling. This bone remodeling cycle, aided by different types of bone cells, maintain skeleton integrity and bone homeostasis. Disruption in normal bone remodeling leads to an increased porosity of the bone matrix. This in turn decreases bone density and makes the skeleton prone to fractures, thus leading to Osteoporosis.
With more than 8.9 million fractures annually, Osteoporosis is the most common bone degrading disease affecting adults and especially post-menopausal women. Since ages, Osteoporosis has baffled the medical and the social community in terms of medical research, human suffering, and economic burden. In UK alone, the prevention and management-associated cost is estimated to face a 30% increase by 2030, according to a survey by the International Osteoporosis Foundation.
The first clinical manifestation of Osteoporosis is mostly in the form of a fracture as bone deterioration is a clandestine process without any significant visible symptoms other than fatigue. People are generally unaware of their osteoporotic condition until a fall or any mechanical jerk results in a hip, vertebrae or wrist fracture. Loss of height and stooping can also occur due to deformities in the spine.
Role of Regenerative Medicine in Osteoporosis
Osteoporosis is intimately associated with bone frailty and fractures, with progressive structural and functional damage. A comprehensive osteoporosis prevention regime typically involves exercise, proper nutrition in diet and safety measures to prevent falling. The available treatment options for osteoporosis with anti-resorptive and anabolic drugs have limited efficacy for bone regeneration and thus promote the need for developing new therapeutic agents.
Regenerative medicine employs stem cells as workers for tissue regeneration and damage healing. Stem cells are the ‘smart’ cells of our body that can differentiate into various body tissue types and therefore supply new and healthy body cells to restore the damage. This unique property of stem cells makes Regenerative medicine, future gold-standard therapy for various neural disorders, orthopedic disorders and other tissue-specific diseases.
Several scientific reports suggest the role of musculoskeletal stem cells in bone tissue homeostasis and bone regeneration. In case of Osteoporosis, the natural stromal cell population and their role in bone restoration is significantly affected and therefore, transplantation of healthy bone-marrow or adipose-derived stromal cells from one’s own body can help the cause effectively without any severe immune rejection problem. As the stromal cells used in the treatment are derived from patient’s own body with informed consent, any ethical issue associated with it is also nullified.
Regenerative medicine seems to be the most viable option for Osteoporosis as various scientific research reports have established the role of autologous stromal cells in bone damage prevention, bone matrix repair, a proliferation of the bone cells and rejuvenation of the in-situ stem cells through strong paracrine signaling pathways. It is a safe, minimally invasive, and site-specific treatment that eases the pain and incidence of fractures by promoting anti-inflammatory regulation in the regions of bone damage and thus help in the improvement of body movements.
Worldwide, more and more clinical research is being carried out for improving the efficacy and regulatory measures of Regenerative medicine, to make it a routine choice of treatment in the future, for body-damaging disorders like Osteoporosis. We, at Advancells, believe that Regenerative Medicine will soon shed the chains of ethical regulations and become an easily accessible and significantly effective alternative.
Advancells is one of the pioneer stem cell research-oriented companies in India, which is focused on therapeutic applications of Regenerative Medicine. Backed by experienced global medical practitioners and clinical research scientists, Advancells passionately believes in the limitless potential of autologous human stem cells in providing a safe and natural cure for any tissue-specific disorder.
For more information, visit https://advancells.com/