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Stem cell treatment for autism is a rapidly evolving theme of research in the medical community. Though stem cell treatment is an experimental avenue, various establishments promote stem cell therapy for autism by promising cures, but most of these establishments offer nothing but false promises, and almost none explain their approach towards treatment, which generates a lot of confusion amongst people looking for alternative treatment options. This article provides few poignant questions to ask establishments before indulging in stem cell therapy.

What kind of stem cells can be used to treat autism? 

Not all stem cells are equal. Their effects vary from location to location. Below given is a diagrammatic illustration of diverse stem cells and linked sources for the treatment of autism and their mechanisms of action.

Type of stem cells Source Mechanism of action
Mesenchymal stem cells Umbilical cord, Bone marrow Secretion of some anti-inflammatory and survival-promoting molecules and neuroprotective effects
Neural stem cells (NSCs) Brain Secretion of neurotrophic factors, maintenance of homeostasis, neuroprotective effects and differentiation into neural-type cells
Umbilical cord- and amniotic fluid-derived stem cells Umbilical cord, placenta, amniotic fluid In vitro growth capacity, low immunogenicity and immunomodulation properties
Induced pluripotent stem cells (iPScs) Any cell type Differentiation capacity

 

  • Mesenchymal stem cells have the ability of rapid propagation, differentiation into cell types of endodermal and ectodermal ancestries, emissions of various trophic factors, and immunomodulatory action, which make them an excellent choice for stem cell therapy. A study conducted by Lvetal .,(2013) examined the safety and efficiency of umbilical cord-derived mesenchymal stem cells (UCMSCs) in treating children with autism. They stated safe and statistically substantial improvements.

 

  • Neural stem cells can be isolated from the fetal and adult human brain and possess the potential for wide proliferation and differentiation into three major cell types of the nervous system- the neurons, astrocytes (cells that provide support to the neurons), and oligodendrocytes (contribute in forming higher-order neuronal circuits). The culture-expanded neural stem cells are multipotent, have the capability to differentiate into numerous neuronal cell types, secrete neurotrophic factors, neural tissue integration, uphold homeostasis, and are neuroprotective, making them a perfect applicant for treating autism.

 

  • Umbilical cord- and amniotic fluid-derived stem cells can aid the generation of new blood vessels in the autistic brain. According to a study by Riordan et al., (2019), umbilical cord-derived stem cells possess anti-inflammatory and immune-modulatory characteristics which caused improvements in autism spectrum disorder symptoms and inflammatory cytokine levels in a group of children.

 

  • Induced pluripotent stem cells (iPScs) could represent a novel tool for autism therapy. The chief benefit of these stem cells is their easy way of isolation from any cell type without the necessity for embryos and that they assist as an unlimited cell source for autologous therapy. Since iPSC models are extensively used to mimic crucial aspects of early human (neuro)development, they are considered predominantly useful for investigating autism-related alterations in neuronal function and connectivity.

 

What stem cell research exists for autism? 

Autism is an excellent applicant for stem cell therapy since evidence exists that stem cells, given intravenously, can improve the total immune system regulation and neural connectivity in the brain. A study by Dr Kurtzberg’s team at Duke published results of significant improvements in children with autism; noteworthy improvements in children’s behaviour were observed on parent-report measures of social communication skills and autism symptoms. Expressive vocabulary, and objective eye-tracking measures of children’s attention to social stimuli, were noted. Behavioural developments were also observed.

How to know if stem cell treatment is the right treatment option for Autism?

The conventional treatment and medication options available for children with autism are not much help; there is no definite medicine or therapy to “cure” autism disorder in a conventional manner. Therefore, alternative therapies are being explored, such as stem cell therapy. Stem cell therapy delivers the finest scope of improved development when recommended during early diagnosis. Though stem cell therapy is an experimental avenue, numerous parents have witnessed a better quality of life for their children when stem cell therapy reinforced the rehabilitation therapies.

Where can you get autism therapy now? 

Although various establishments claim to treat Autism with stem cell therapy, the stem cells provided by them, are not quality correct or optimally processed. Most institutes propose false promises of a guaranteed cure.

Taking these concerns into account, Advancells is the best institute for treating Autism in India. Advancells doesn’t make any fake promises and delivers quality characterized stem cells. Children have revealed decreased hyperactivity, better day-to-day activity performance, and enhanced response to social stimuli. Advancells has recognized several rich and securely accessible stem cell niches in the human body for effective and augmented stem cell therapy to repair and regenerate damaged tissue. For free medical consultation on stem cell therapy, contact info@advancells.com 

 

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