Diabetes also known as diabetes mellitus is a chronic metabolic disorder. People suffering from diabetes have increased blood-glucose level either due to insufficient insulin production by the pancreatic islet cells, or inability of the body cells to respond to insulin properly, or combination of both.Thus, body becomes unable to utilize glucose present in food and glucose gets accumulated in blood.This high blood glucose levels, if not controlled, usually damage the small blood vessels of the kidneys, heart, eyes, nervous system and subsequently lead to kidney failure, heart attack, blindness, stroke, and nerve damage.
Diabetes mellitus is mainly of two types: Type 1 and Type 2. Type 1 is an autoimmune disorder, where insulin-producing cells are damaged and thus little or no insulin is produced by the body. In Type 2, insulin is produced but fails to function properly, a condition called insulin resistance that eventually reduces insulin production. Type 2 is more common than Type 1 and accounts for about 90-95% of the total diabetic cases.
Symptoms
Both Type 1 and Type 2 diabetes has some common symptoms. They are as follows:
- Extreme hunger and fatigue
- Frequent urination
- Dry mouth and itchy skin
- Sudden vision change and blurred vision
- Unexplained weight loss
- Frequent infection
- Slowly healing sores
- Tingling or numbness in the limbs
- Nausea or vomiting tendency
Why diabetes is a major public health concern?
Diabetes is a serious global problem affecting millions of individuals both adults and children. Diabetes is contemplatedas biggest epidemic in the twenty-first century. Diabetes is considered as a ‘silent killer’ as it damages most of the organs of the body. Thus, it is extremely important to address this concern as soon as possible by developing proper and effective treatment.
How is diabetes treated?
Conventional therapy for diabetes includes insulin injection or replacement of the pancreatic beta cell via pancreatic islet transplantation. But one problem faced by the physicians in case of pancreatic islet transplantation is that primary human islets are not easily available. Thus researchers have to think about an effective alternative therapy to treat diabetic patients.
The alternative approach is the Stem cell therapy. Stem cells are a class of undifferentiated cells, which can differentiate into specialized cell types under right conditions and can self-renew. In this approach autologous (one’s own) stem cells are used. As the stem cells are introduced into the body they are able to promote regeneration of the impaired or lost pancreatic islet cells, which produce insulin and this insulincan, recognize and utilize glucose normally.
What types of stem cells are used for the treatment?
Stem cells from different sources such as adult and embryonic stem cells can be used. Both types have some advantages.Embryonic stem cells have highest potential to differentiate into insulin secreting cells. Mesenchymal stem cells (MSCs) derived from human adult tissues are also good source of stem cells since they have high capacity to self-replicate and differentiate.
Why adult autologous stem cells are mostly used for stem cell therapy?
Nowadays, stem cell therapy using adult autologous stem cells is becoming a promising approach to treat various metabolic and neuro degenerative disorders. The most probable use of the adult stem cells include development of insulin-producing cell for type 1 diabetes, repairing damaged heart muscle with cardiac muscle cells after heart attack, and regenerating bone using cells derived from bone marrow stroma. As the patients are receiving their own stem cells there is no chance of immune rejection.
Furthermore, MSCs are found to be beneficial for management of several diabetic conditions, such as progression of diabetic nephropathy, attenuation of symptoms of diabetic neuropathy, and healing of diabetic foot. Besides, mild effects related to injection such as swelling or irritation at the injection site that can be addressed by over-the-counter pain medication no major adverse effects have been reported. However, the medical practitioner must be well experienced with this technique. Moreover, further researches are needed to get a clearer picture of this therapy so that it can be used for curing vast number of disorders.
In which area it is cured ???
Dear Rajesh, we did not understand your question. In order to serve you better, it will be great if you can possibly elaborate more about what you wish to understand about stem cell therapy?
Iam suffering from diabetes 15y, newly diagnosed microulbuminuria & liver fibrosis grade 1
dbandal 5474@gmail.com
Dear Mr. Bandal
Thank you for showing interest in Advancells. Allogenic stem cells isolated from umbilical cord matrix have expressed immunomodulatory properties that are helpful in minimizing autoimmune destruction of pancreatic beta cells in case of diabetes. Moreover, chronic increase in blood sugar can lead to multiple organ damage, including fatty liver and liver fibrosis. However, stem cells cannot reverse the damage associated with liver fibrosis, they can definitely delay progressive damage of the organ and facilitate functional restoration.
In order to analyse your report in a better way, we would like to request you to send your medical reports to us at care@advancells.com for further assessments. You can as well call us at 9654321400 for quick evaluation.
Thanks & Regards
I am diabetic last 5 years also fatty liver. I saved my daughter’s cord stem cell. Please let me know where i can take a treatment of it. Also I am type 2 diabetic patient.
Dear Harish k.
Thank you for trusting Advancells. Stem cells can be helpful in delaying the progression of liver damage as well as at the same time increasing the self-regeneration efficiency of the liver. The immunomodulatory properties of stem cells can also be helpful in preventing damage of self organs associated with autoimmune disorders like diabetes. However, the extent of regeneration is quite patient specific, and as well quite dependent upon the type of cells infused in the body. Please share your detailed medical reports to us at care@advancells.com and also whatsapp them to +91-9654321400.This would further help us to evaluate your condition in a better way. Also send us details of the cord banking so that we would be able to come up with a definitive treatment options.
Thanks & Regards
I’m suffering from diabetic since last 10 years. I’ve also developed diabetic nerve damage sensation on my foot. Is this stem cell therapy is a one time case or needs to be repeated number of times ? Right now I’m taking oral medication only, after the stem cell treatment do I need to continue my medication? Which hospital is best for stem cell treatment in India ?
Dear Syed Anagh,
Can you please share detailed medical reports to us at care@advancells.com or whatsapp them to +91-9654321400; so that we would assess your case through expert medical professionals on our panel and get back to you at the earliest.
Thanks & Regards
Advancells support Team.
I’m suffering from from diabetes type 1 from last 2 and half years . I am 17 yrs.old. My insulin intake is in high amount 75 units/ day . Can this trearment permanently vanish diabetes from my body ?
Dear Sakshi,
Thank you for contacting Advanells. Although, stem cells have proven to be very effective in minimizing insuling dependency; we dont expect you to be permanently diabetes free at a first instance, post stem cell therapy. However, we can definitly reduce your insuling intake, depending upon your Hb1AC. Before committing you anything, we would like to go through your recent medical reports, mentioning your Hb1Ac and blood sugar level; please mail the same to us at care@advancells.com or whatsapp them to +919654321400.
Once, we get your medical reports, we will get them screened by our expet diabetologist on panel and present a definitive treatment plan.
Thanks & Regards
I have suffering from diabetes ,now I developed progressive proliferative retinopathy with almost loss of vision in the left eye.Is there any specific treatment for improvement of vision and arrest of future complications
Dear Chandrasekhar,
Thank you for contacting Advancells.
We would request you to share recent relevant medical reports and clinical history of the patient for us to revert with an opinion. Please feel free to contact in case of any query Whatsapp number at +91-9654321400 or Email us at care@advancells.com
Thanks & Regards
Advancells Support Team