Stem Cell Treatment For Cerebral Palsy
Cerebral palsy is a broad term used to describe a group of non progressive "chronic palsies" impairing control over movements due to brain damage. Children with CP are most likely born with the condition, but some may acquire later during a first 3-5 years of child's life. The disorder is generally associated with the secondary conditions such as difficulty eating, bladder/bowel problems, seizures and learning disabilities; which can get better or worse over time.
CP is often associated with abnormal brain development or damage to some parts of the brain may be due to poor oxygen supply or internal bleeding. Though it is difficult to pinpoint exact cause, the primary Cerebral palsy causes may be genetic abnormalities, congenital brain malformation, maternal infections or fever etc.
Signs of cerebral palsy include:
- Not blinking at loud noises by one month
- Not sitting by seven months
- Not turning head toward sounds by four months
- Not verbalizing words by 12 months
- Walking with an abnormal gait
There are different types of cerebral palsy that affect various parts of the brain. Each type of cerebral palsy causes specific movement disorders.
Spastic cerebral palsy is the most common form of cerebral palsy, affecting 70-80% of people diagnosed with palsy. Spastic CP is caused by brain damage, either before or during birth or within early stages of life. Spastic cerebral palsy is characterized by hypertonia i.e. increased muscle tone leading to stiffened muscles.
The primary symptoms of spastic cerebral palsy include:
- stiff and tightened muscles
- Jerky movements
- Involuntary limb movement
- Limited stretching ability
- Arms tucked towards body
- Other symptoms of spastic cerebral palsy include seizures, and problem in speech, vision and hearing.
Athetoid cerebral palsy is a type of cerebral palsy characterized by athetosis, or uncontrolled movements. It is caused due to damage and malformations to the extrapyramidal tracts in the basal ganglia or the cerebellum. Damage typically occurs before, during, or shortly after an infantâ€™s birth. Unlike spastic or ataxic cerebral palsies, Athetoid cerebral palsy is characterized by both hypertonia and hypotonia.
The symptoms of Athetoid Cerebral palsy include:
- Uncontrolled movements
- Lack of control in moving leg, hands
- Difficulty in standing in upright position
- Difficulty in grasping objects
- Uncontrolled movements in facial muscles impair speech and swallow
Ataxic cerebral palsy (CP) is the least common type of the disorder, affecting around 5 to 10% of all people with CP. Like other types of cerebral palsy, ataxia cerebral palsy is also a developmental disorder that causes lack of coordination and order.
The symptoms of ataxia cerebral palsy include:
- Tremors and shaky arms
- Difficulty in walking
- Regular falling
- Speech problem
- Difficulty in swallowing
There are many cerebral palsy affected patients, who do not have specific symptoms of single type of Mixed cerebral palsy is type of cerebral palsy having similarities with three other types of cerebral palsy. Mixed Cerebral Palsy accounts for approximately 10% of all people with cerebral palsy. Mixed C.P. is caused from injuries to the brain.
Symptoms of mixed CP include following:
Abnormal muscle tone either stiffer or looser
Impaired or involuntary movements
Difficulty in doing fine motor skills
Difficulty in balancing
Visual or hearing impairment
Difficulty speaking or swallowing, sometimes causing drooling
The severity of symptoms of mixed cerebral palsy is dependent on severity of a personâ€™s brain injuries.
This damage to brain cannot be reversed with the current treatments available. Conventionally only supportive treatments were present to temporarily relieve the pain or the symptoms, additionally there are many support services available for the effective management of some activities and programs such as day care services or nursing programs. Although the damage in terms of death of neurons cannot be halted or reversed with this treatment approach till the discovery of stem cells. For the children with CP who struggling for the normal life style; stem cells technology has come up as the new ray of hope. Apart from tendency to give rise to healthy neurons; these stem cells also has a unique ability to identify and home in the affected area. These cells are also responsible for creation of microenvironment and secretion of hormones for faster rejuvenation.
Stem cells are the master cells of the body, mainly differentiating into the required type of cells upon administering a proper cocktail of growth factors and stimulatory agents in vitro. The stem cell therapy approach mainly focuses on delivering the sufficient number of Adult Autologous Stem Cells which will travel into multiple areas of the brain where the damage has occurred.These transplanted stem cells are potential to transform into new brain cells which are needed for the replacement of damaged cells. They also help in creating a microenvironment that will secret some of the enzymes required for making connections to replace lost parts of the complex network. We all should understand that stem cell treatment is not a temporary solution but a long term goal; through which it is possible to live in a better way.
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Stem Cell Treatment For Cerebral Palsy: Advancells Protocol
At Advancells, we have been providing assistance to many children for coping up with the problems and to find out permanent solution. We are exploiting the most potent Stem Cells isolated from patients own Bone Marrow or Adipose tissue or may be both depending upon the assessment. Our top priority is to provide very comprehensive, individualized treatment pattern which is best suited for the patients undergoing treatment.
Our aim here in Advancells is to help the child to achieve as much independence as possible throughout his/her life.
Step 1- Qualification For The Treatment
A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pretreatment assessments can be suggested depending upon the patient's medical and family background:
- Routine Blood Tests
- Routine Urine Analysis
- Infectious disease testing
- Physical Examination
- X Ray
- CT Scan
- Medical Neurological Reports
- Medical History
As per these results, the patient will be counseled further for final decision of protocol.
Step 2- Source Extraction
With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolated from Bone Marrow or Adipose Tissue, as these are the most potent autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cells stimulation therapy for some, depending upon the severity and requirement.
The specified amount of samples will be extracted from the patient's own body on the intimated date and time, with the application of local anesthesia. The entire procedure takes around 7-8 hrs, however, in case of extraction from both the sources the patient has to be with us for a little longer time.
If you are curious to know more about the procedure, kindly refer our detailed snapshot below:
Step 3- Laboratory Processing
The extracted sample, will be sent to the government approved cGMP laboratory for processing. The sample processing will be done in a state of the art class 10,000 clean room in compliance with the ISO and GMP standards.
The sample will undergo minimum manipulation in our complete automated Sepax technology to be enriched with the pure population of stem cell culture. The isolated stem cells will be characterized for quality, purity and viability.
The client will be given a third party certificate from Internationally Accredited Lab for the quality purpose.
Step 4- Stem Cell Implantation
Once stem cells are enriched and ready to be injected back into the body, we have worked on different modes of implanting them. However, depending upon the patient's physiological and mental well being, one of the following will be finalized by our experts.
Intravenous Injection:- Stem cells will be infused into the body, by infusing through the vein.
- Intra-thecal Injection:- Stem cells will be infused, into the cerebro-spinal fluid into the spinal canal. This route is most popularly known as Lumbar Puncture
Follow up Treatment
In a post treatment care, the patient will be asked to visit the doctors after a specific period of time, for some rehabilitation programs, including Behavioural and emotional development, Communication and social Interaction, Self regulation, Cognitive & Adaptive skills.