Stem Cell Research for Cerebral Palsy

Stem cells and stem cell-derived exosomes are uniquely formulated to mitigate brain damage due to hypoxia.

This advanced formulation can be helpful in the suppression of inflammatory response, down-regulation of damage-inducing DNAs, and upregulation of DNA repair genes to facilitate faster recovery.

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Stem Cells for Cerebral Palsy Treatment

For neurodegenerative conditions like Cerebral Palsy, experts are relying upon stem cells and exosomes that can maneuver the expansion and differentiation potential of resident stem cells to promote regeneration of dead/damaged neurons that were lost due to external assaults, like hypoxia during birth. Advancells has developed a robust yet quality controlled technique to culture stem cells at a mass scale along with their exosomes to obtain desired effects in Cerebral Palsy.

Stem Cells for Cerebral Palsy: Advancells Protocol

The primary goals of the unique combinational protocol of cell-based therapies suggested at Advancells are to replenish cells that are damaged, restore circulatory growth and anti-inflammatory modules, and normalize the microenvironment to regulate the activity of the central nervous system for better clinical outcomes. In today’s era of personalized treatment lot of factors are taken into consideration, depending upon individual need; before suggesting a comprehensive treatment plan. Being GMP compliant facility, all our protocols are audited for compliance and quality. Our therapeutic-grade extracellular vesicles are loaded with specific proteins for better cellular communication, epigenetic changes, and a higher degree of regeneration. This proprietary technology platform is helpful in better clinical outcomes.

Procedure of Treatment of Cerebral Palsy through Stem Cells Therapy

Treatment Qualification

Source Extraction

Processing of stem cells

Re-infusion

STEM CELLS THERAPY

STEM CELLS PROCEDURE

RESULTS

Cerebral Palsy is a group of neurodegenerative disorders, characterized by decreased ability to move, balance maintain posture. Depending upon the area of the brain affected cerebral palsy can further be classified into different types

Stiff, tight muscles on both sides of the body

Limited mobility

Abnormal gait/posture

Crossed knees

Walking on tiptoes

Contractures

Squinting and/or uncontrollable eye movements

Developmental delays

Abnormal posture, uncontrollable body movements

Possible difficulties with swallowing food

Excessive involuntary movements

Pain during abnormal movements

Poor coordination

Walking unsteadily

Poor balance

Difficulty with fine motor tasks

Changes in speech

Involuntary back-and-forth eye movements

Clumsiness

Developmental delays

Excessive muscle flexibility

Difficulty chewing or swallowing

Flexible joints and ligaments

Lack of head control

Cerebral Palsy is a group of non-progressive neuromuscular disorders caused due to complications during pregnancy and the birthing process. With years of aggressive research, scientists can confirm various factors that are responsible for abnormal brain damage during the gestational period, which may increase the chances of cerebral palsy.

Children with low birth weight, less than 5.5 pounds at birth may have a greater chance of developing cerebral palsy; later in life.
Children, who were born before the 37th week of pregnancy due to pregnancy-induced complications like fluctuating blood pressure, high diabetes, jaundice, etc. may exhibit higher chances of developing cerebral palsy.
Children with multiple births, like twins, triplets, etc. particularly after the process of IVF can display higher chances of cerebral palsy. Most of these risks are explained during the consultation.
Vaginal infections during pregnancy can increase inflammation due to the secretion of certain cytokines and other proteins; which may circulate in the blood and degenerate other organs as well. This may increase the chances of cerebral palsy.
Jaundice or acute cholestasis during pregnancy can increase the chances of premature birth; thereby increasing the risk of cerebral palsy.
Mothers with thyroid problems, intellectual disability, or seizures are at higher risk of having a child with cerebral palsy.
Other birth complications like detachment of the placenta, uterine rupture, and problems with the umbilical cord during birth may disrupt the oxygen supply to the baby causing severe brain damage and/or cerebral palsy.

Studies have indicated that stem cell-induced brain plasticity is very crucial to regulating the pathophysiology of damaged brain and the treatment of cerebral palsy. This feature has directed us towards functional recoveries and rehabilitation therapies that aim to capitalize on optimum physical, sensory, intellectual, psychological as well as social functioning. We believe in Bobath Approach which is also known as neurodevelopmental treatment and is developed by Bobath in the 1940s; and has been acknowledged by industry experts for accurate assessments and effectiveness.

Since stem cells can rejuvenate and differentiate into a variety of cell types, stem cells have the potential to manage various neurological conditions including cerebral palsy. A lot of evidence from pre-clinical and clinical research suggests the efficacy of stem cell therapy for cerebral palsy:

Worldwide Clinical Studies using Stem Cells obtained from different sources

75% of children have observed increases in muscle tone post-therapy

75% of children have observed increases in muscle tone post-therapy
55% of children with CP have observed better hand and legs movements
50% of people have reported improvement in their speech pattern
35% of CP patients have witnessed enhanced sitting balance post-stem cell therapy
10% of patients observed better cognition during the therapy

We have effectively used stem cell therapy and exosome technology to provide successful therapy to our patients dealing with cerebral palsy. Check out some of our successful cerebral palsy testimonials and improvements witnessed by our patients:

Thermishaa Soman, 4 year old Cerebral Palsy with Cortical Visual Impairment

Thermishaa was born on 4th December 2013, as a normal full term baby. When she was 11 months old, her mom noticed that Thermishaa was not as active as the other children of her age would be! At the specified age, Thermishaa was not hitting any milestones, which…
Martin Marinov, Cerebral Palsy Patient Treatment Story

Martin Marinov is a 5 year old child from Bulgaria who was delivered as a preterm baby and suffered asphyxia during childbirth. Unfortunately, the loss of oxygen for a few precious seconds resulted in some brain damage to the child leading to a condition known as…
Jona Ghelli, 16 years, Cerebral Palsy

Home Country: Holliston, Massachusetts, USA Diagnosis Jona Ghelli, a 16-year-old, was diagnosed with cerebral palsy and microcephaly which results in significant cognitive and physical impairments. She also suffers from a seizure disorder. Microcephaly is a…

READ CEREBRAL PALSY SUCCESS STORIES

TYPES OF CEREBRAL PALSY

Cerebral Palsy is a group of neurodegenerative disorders, characterized by decreased ability to move, balance maintain posture. Depending upon the area of the brain affected cerebral palsy can further be classified into different types:

Spastic Cerebral Palsy

Stiff, tight muscles on both sides of the body

Dyskinetic Cerebral Palsy

Squinting and/or uncontrollable eye movements

Abnormal posture, uncontrollable body movements

Possible difficulties with swallowing food

Cerebral Ataxia

Problems in muscles coordination — Changes in speech

Involuntary back-and-forth eye movements

Hypotonic Cerebral Palsy

CAUSES OF CEREBRAL PALSY

Cerebral Palsy is a group of non-progressive neuromuscular disorders caused due to complications during pregnancy and the birthing process. With years of aggressive research, scientists can confirm various factors that are responsible for abnormal brain damage during the gestational period, which may increase the chances of cerebral palsy.

Children with low birth weight, less than 5.5 pounds at birth may have a greater chance of developing cerebral palsy; later in life.
Children, who were born before the 37th week of pregnancy due to pregnancy-induced complications like fluctuating blood pressure, high diabetes, jaundice, etc. may exhibit higher chances of developing cerebral palsy.
Children with multiple births, like twins, triplets, etc. particularly after the process of IVF can display higher chances of cerebral palsy. Most of these risks are explained during the consultation.
Vaginal infections during pregnancy can increase inflammation due to the secretion of certain cytokines and other proteins; which may circulate in the blood and degenerate other organs as well. This may increase the chances of cerebral palsy.
Jaundice or acute cholestasis during pregnancy can increase the chances of premature birth; thereby increasing the risk of cerebral palsy.
Mothers with thyroid problems, intellectual disability, or seizures are at higher risk of having a child with cerebral palsy.
Other birth complications like detachment of the placenta, uterine rupture, and problems with the umbilical cord during birth may disrupt the oxygen supply to the baby causing severe brain damage and/or cerebral palsy.

SUPPORTIVE THERAPY

Studies have indicated that stem cell-induced brain plasticity is very crucial to regulating the pathophysiology of damaged brain and the treatment of cerebral palsy. This feature has directed us towards functional recoveries and rehabilitation therapies that aim to capitalize on optimum physical, sensory, intellectual, psychological as well as social functioning. We believe in Bobath Approach which is also known as neurodevelopmental treatment and is developed by Bobath in the 1940s; and has been acknowledged by industry experts for accurate assessments and effectiveness.

OUTCOMES

Since stem cells can rejuvenate and differentiate into a variety of cell types, stem cells have the potential to manage various neurological conditions including cerebral palsy. A lot of evidence from pre-clinical and clinical research suggests the efficacy of stem cell therapy for cerebral palsy:

Worldwide Clinical Studies using Stem Cells obtained from different sources

Improvement in clinical signs and symptoms

75% of children have observed increases in muscle tone post-therapy
55% of children with CP have observed better hand and legs movements
50% of people have reported improvement in their speech pattern
35% of CP patients have witnessed enhanced sitting balance post-stem cell therapy
10% of patients observed better cognition during the therapy

TESTIMONIAL

We have effectively used stem cell therapy and exosome technology to provide successful therapy to our patients dealing with cerebral palsy. Check out some of our successful cerebral palsy testimonials and improvements witnessed by our patients:

Thermishaa Soman, 4 year old Cerebral Palsy with Cortical Visual Impairment

Thermishaa was born on 4th December 2013, as a normal full term baby. When she was 11 months old, her mom noticed that Thermishaa was not as active as the other children of her age would be! At the specified age, Thermishaa was not hitting any milestones, which…
Martin Marinov, Cerebral Palsy Patient Treatment Story

Martin Marinov is a 5 year old child from Bulgaria who was delivered as a preterm baby and suffered asphyxia during childbirth. Unfortunately, the loss of oxygen for a few precious seconds resulted in some brain damage to the child leading to a condition known as…
Jona Ghelli, 16 years, Cerebral Palsy

Home Country: Holliston, Massachusetts, USA Diagnosis Jona Ghelli, a 16-year-old, was diagnosed with cerebral palsy and microcephaly which results in significant cognitive and physical impairments. She also suffers from a seizure disorder. Microcephaly is a…

READ MALE INFERTILTTY SUCCESS STORIES

Must Read Articles on Cerebral Palsy

Hope and Limitations: Exploring Stem Cell Therapy for Cerebral Palsy

Cerebral palsy (CP) is one of the most complex neurological disorders affecting motor function. It is often accompanied by other impairments like communication, sensory processing, and muscle coordination. The condition takes its toll by affecting infants or children...

Athetoid Cerebral Palsy: Innovative Treatment Approaches

Cerebral palsy is a group of lifelong movement disorders that appear early in childhood. This condition happens when the developing brain is damaged during or just before birth. It leads to children not having the ability to control movement, muscle tone, balance, and...

What are the Characteristics of Locomotor Disability?

What is the Meaning of Locomotor Disability? When we think of movement and mobility, we often take it for granted. But for individuals with cerebral palsy, movement can be a constant challenge. Locomotor disability related to cerebral palsy can greatly impact an...

0verall Improvement of Cerebral Palsy Disease through Stem Cells

A lot of trials are going on currently worldwide, however, with specified inclusion and exclusion criteria the current meta-analysis is done on eight relevant trials (Henna SE. et.al; 2008). Four of these trials are conducted in the United States, one is in China, and three are conducted in Korea. The risk of bias was assessed in an individual study using Cochrane criteria, ranging from low to high. Although no significant risk is observed in all 8 studies, the data is estimated to be insufficient to propose the risk of publication bias (Sun JM. et. al;2017). All trials applied standardized scales to assess the neurodevelopmental outcome, including fine and motor skills, cognitive functions, and spasticity.

In conclusion, stem cell therapy for CP shows a significant positive effect on gross motor functions, although the magnitude of improvement is variable. Overall the novel treatment seems safe, but long-term study outcomes are still lacking. Download

Body Rejuvenation

Enhanced Perception

Improved reflex

Improved Peflex

Improvement in speech

Improvement in Speech

Improvement in motor skills

Improvement in Motor Skills

FAQs

Are there different types of cerebral palsy?

There are several different types of cerebral palsy: spastic diplegia, spastic hemiplegia, spastic quadriplegia, athetoid dyskinetic cerebral palsy, choreoathetoid dyskinetic cerebral palsy, dystonic dyskinetic cerebral palsy, ataxic cerebral palsy, hypotonic cerebral palsy, and mixed cerebral palsy. The spastic forms of CP are characterized by stiff muscles and muscle spasms. The dyskinetic forms of CP are characterized by involuntary, writhing movements. Ataxic CP, the least disabling of all the forms, is characterized by balance and depth perception problems which make walking difficult. Hypotonic CP is characterized by overly relaxed, "floppy" muscles. As the name implies, mixed CP is characterized by symptoms of two or more forms of the disorder.

What is congenital CP?

The term congenital means present at birth. Between 90 to 95 percent of CP cases are congenital. Congenital CP includes those cases which were caused by oxygen deprivation during birth. Doctors used to believe that most cases of CP were caused by a lack of oxygen during a difficult labour and delivery, but it is now known that fewer than 10 percent of congenital cerebral palsy cases stem from asphyxia or other problems during birth. The majority of problems that cause CP occur during development in the womb. Brain trauma, infections, strokes, and other problems after birth can occasionally cause acquired CP. As the name implies, acquired CP means that the condition was acquired after birth.

Can cerebral palsy be cured?

Cerebral palsy cannot be cured. The brain damage or brain abnormalities from which it stems are irreversible. Fortunately, today much can be done to improve the quality of life for CP patients.

How can stem cells be beneficial to treat Cerebral Palsy?

Undifferentiated adult autologous stem cells are mutable and can metamorph into countless number of cells as per the requirement. This remarkable property of stem cells can be exploited for treating a variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with the great speed to restore damaged fibres, regenerate neuron as well can improve damaged function.

Where can I get full information about the Disease?

Please go through, our treatment brochures for other Cerebral Palsy related information.