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Cerebral Palsy Treatment

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    Stem Cell Treatment for Cerebral Palsy

    Despite advances in perinatal medicine there have been increasing evidence of births with congenital brain defects; further leading to increased prevalence of cerebral palsy, a heterogeneous group of conditions resulting in permanent, non-progressive, developmental dysfunction in the brain. Depending upon the risk factors associated children with CP can exhibit variable symptoms from as minor as weal attention span to as major as difficulty in walking or speaking. This debilitating disease has been proven to be a logical target for stem cell therapy in clinical as well as preclinical setup. Studies have confirmed the effectiveness of stem cell-based therapies along with exosome therapy; particularly because damage to the central nervous system is non-progressive involving inflammation of multiple neuronal cells. Advancells has come up with the latest technology of exosome therapy administered in combination with stem cells. Patients who have undergone treatment with the help of this combinational approach have shown great improvements.

    Stem Cell Therapy for Cerebral Palsy: Advancells Protocol

    The primary goals of the unique combinational protocol of cell-based therapies suggested at Advancells are to replenish cells that are damaged, restore circulatory growth and anti-inflammatory modules, and normalize the microenvironment to regulate the activity of the central nervous system for better clinical outcomes. In today’s era of personalized treatment lot of factors are taken into consideration, depending upon individual need; before suggesting a comprehensive treatment plan. Being GMP compliant facility, all our protocols are audited for compliance and quality. Our therapeutic-grade extracellular vesicles are loaded with specific proteins for better cellular communication, epigenetic changes, and a higher degree of regeneration. This proprietary technology platform is helpful in better clinical outcomes.

    Procedure of Treatment of Cerebral Palsy through Stem Cells Therapy

    Treatment Qualification

    Source Extraction

    Processing of stem cells

    Re-infusion

    Cerebral Palsy is a group of neurodegenerative disorders, characterized by decreased ability to move, balance maintain posture. Depending upon the area of the brain affected cerebral palsy can further be classified into different types
    Stiff, tight muscles on both sides of the body
    Limited mobility
    Abnormal gait/posture
    Crossed knees
    Walking on tiptoes
    Contractures
    This is the most common form of Motor Neuron Disease, named after the baseball player Mr. Lou Gehrig; who was by far the most famous person of his time to develop MND.
    Squinting and/or uncontrollable eye movements
    Developmental delays
    Abnormal posture, uncontrollable body movements
    Possible difficulties with swallowing food
    Excessive involuntary movements
    Pain during abnormal movements
    Central lateral Neurosis, also known as Primary Lateral Neurosis is a rare degenerative disorder of upper motor neurons, mainly affecting central motor neurons. This is a slowly progressive disorder and generally, degeneration may begin with one leg; gradually affecting both legs and arms. (icons ke niche)
    Poor coordination
    Walking unsteadily
    Poor balance
    Difficulty with fine motor tasks
    Changes in speech
    Involuntary back-and-forth eye movements
    This is another form of motor neuron disease, mainly affecting lower motor neurons responsible for chewing, swallowing, etc. The course of illness and the fatal prognosis is similar to that of Amyotrophic Lateral Sclerosis.
    Clumsiness
    Developmental delays
    Excessive muscle flexibility
    Difficulty chewing or swallowing
    Flexible joints and ligaments
    Lack of head control
    Kennedy disease, also known as spinobulbar muscular dystrophy is a rare form of motor neuron disease, affecting only men; while females can be carriers. The symptomatic exhibition of Kennedy disease, unfortunately, starts at a very early stage; as early as 30 years of age.
    Cerebral Palsy is a group of non-progressive neuromuscular disorders caused due to complications during pregnancy and the birthing process. With years of aggressive research, scientists can confirm various factors that are responsible for abnormal brain damage during the gestational period, which may increase the chances of cerebral palsy.
    • Children with low birth weight, less than 5.5 pounds at birth may have a greater chance of developing cerebral palsy; later in life.
    • Children, who were born before the 37th week of pregnancy due to pregnancy-induced complications like fluctuating blood pressure, high diabetes, jaundice, etc. may exhibit higher chances of developing cerebral palsy.
    • Children with multiple births, like twins, triplets, etc. particularly after the process of IVF can display higher chances of cerebral palsy. Most of these risks are explained during the consultation.
    • Vaginal infections during pregnancy can increase inflammation due to the secretion of certain cytokines and other proteins; which may circulate in the blood and degenerate other organs as well. This may increase the chances of cerebral palsy.
    • Jaundice or acute cholestasis during pregnancy can increase the chances of premature birth; thereby increasing the risk of cerebral palsy.
    • Mothers with thyroid problems, intellectual disability, or seizures are at higher risk of having a child with cerebral palsy.
    • Other birth complications like detachment of the placenta, uterine rupture, and problems with the umbilical cord during birth may disrupt the oxygen supply to the baby causing severe brain damage and/or cerebral palsy.
    Studies have indicated that stem cell-induced brain plasticity is very crucial to regulating the pathophysiology of damaged brain and the treatment of cerebral palsy. This feature has directed us towards functional recoveries and rehabilitation therapies that aim to capitalize on optimum physical, sensory, intellectual, psychological as well as social functioning. We believe in Bobath Approach which is also known as neurodevelopmental treatment and is developed by Bobath in the 1940s; and has been acknowledged by industry experts for accurate assessments and effectiveness.
    Strength Training Muscular weakness is a preliminary impairment observed in the case of CP. Our strength training programs help strengthen muscles without any adverse events. It also helps to gain good balance and posture for improved functional motor performance.
    Sensory IntegrationSome kids are oversensitive to certain types of stimulation. Due to this sensory overload, the human brain fails to process information at the same time. At the same time, some children with CP are undersensitive and do not process sensory information at all. In either case, our sensory integration programs help to be more organized and structured; to be able to process all senses together with more efficiency.
    Endurance TrainingWe have also observed that children with CP display a very low degree of endurance in cardiovascular exercises and stamina-building exercises. This can lead to a negative health outcome. Our endurance training program can effectively physical fitness for leading a better quality of life.
    Hyperbaric Oxygen TherapyIt provides a higher concentration of oxygen delivered in a chamber with higher atmospheric pressure. The condition initiates hypoxia in the brain to facilitate improved oxygenated blood flow towards the brain, hence indirectly improving the flow of stem cells towards the target.
    Diet Education and CounsellingFor some children with CP, certain dietary changes have reportedly produced dramatic differences in the symptomatic exhibition and functional improvements. With good scientific investigation, experts believe that children with CP are to be evaluated for certain dietary modifications, either in combination or alone; in order to evaluate significant functional improvement in the brain.
    HydrotherapyHydrotherapy, also known as aquatic therapy involves therapeutic immersion of the body in water and performing physical exercises against altered density, gravity, and hydrostatic pressure of water to promote physical changes. It has been identified to be beneficial in better muscular strength and functional improvements.

    We have effectively used stem cell therapy and exosome technology to provide successful therapy to our patients dealing with cerebral palsy. Check out some of our successful cerebral palsy testimonials and improvements witnessed by our patients:

    • Thermishaa Soman, 4 year old Cerebral Palsy with Cortical Visual Impairment

      Thermishaa was born on 4th December 2013, as a normal full term baby. When she was 11 months old, her mom noticed that Thermishaa was not as active as the other children of her age would be! At the specified age, Thermishaa was not hitting any milestones, which…

    • Martin Marinov, Cerebral Palsy Patient Treatment Story

      Martin Marinov is a 5 year old child from Bulgaria who was delivered as a preterm baby and suffered asphyxia during childbirth. Unfortunately, the loss of oxygen for a few precious seconds resulted in some brain damage to the child leading to a condition known as…

    • Jona Ghelli, 16 years, Cerebral Palsy

      Home Country: Holliston, Massachusetts, USA Diagnosis Jona Ghelli, a 16-year-old, was diagnosed with cerebral palsy and microcephaly which results in significant cognitive and physical impairments. She also suffers from a seizure disorder. Microcephaly is a…

    Since stem cells can rejuvenate and differentiate into a variety of cell types, stem cells have the potential to manage various neurological conditions including cerebral palsy. A lot of evidence from pre-clinical and clinical research suggests the efficacy of stem cell therapy for cerebral palsy:

    Worldwide Clinical Studies using Stem Cells obtained from different sources

    75% of children have observed increases in muscle tone post-therapy
    TYPES
    Cerebral Palsy is a group of neurodegenerative disorders, characterized by decreased ability to move, balance maintain posture. Depending upon the area of the brain affected cerebral palsy can further be classified into different types:

    Stiff, tight muscles on both sides of the body
    Stiff, tight muscles on both sides of the body

    Limited mobility
    Limited mobility

    Abnormal gait/posture
    Abnormal gait/posture

    Crossed knees
    Crossed knees

    Walking on tiptoes
    Walking on tiptoes

    Contractures
    Contractures


    Squinting and/or uncontrollable eye movements
    Squinting and/or uncontrollable eye movements

    Developmental delays
    Developmental delays

    Abnormal posture, uncontrollable body movements
    Abnormal posture, uncontrollable body movements

    Possible difficulties with swallowing food
    Possible difficulties with swallowing food

    Excessive involuntary movements
    Excessive involuntary movements

    Pain during abnormal movements
    Pain during abnormal movements


    Poor coordination
    Poor coordination

    Walking unsteadily
    Walking unsteadily

    Poor balance
    Poor balance

    Difficulty with fine motor tasks
    Difficulty with fine motor tasks

    Problems in muscles coordination
    Changes in speech

    Involuntary back-and-forth eye movements
    Involuntary back-and-forth eye movements


    Clumsiness
    Clumsiness

    Developmental delays
    Developmental delays

    Excessive muscle flexibility
    Excessive muscle flexibility

    Difficulty chewing or swallowing
    Difficulty chewing or swallowing

    Flexible joints and ligaments
    Flexible joints and ligaments

    Lack of head control
    Lack of head control

    CAUSES
    Cerebral Palsy is a group of non-progressive neuromuscular disorders caused due to complications during pregnancy and the birthing process. With years of aggressive research, scientists can confirm various factors that are responsible for abnormal brain damage during the gestational period, which may increase the chances of cerebral palsy.

    • Children with low birth weight, less than 5.5 pounds at birth may have a greater chance of developing cerebral palsy; later in life.
    • Children, who were born before the 37th week of pregnancy due to pregnancy-induced complications like fluctuating blood pressure, high diabetes, jaundice, etc. may exhibit higher chances of developing cerebral palsy.
    • Children with multiple births, like twins, triplets, etc. particularly after the process of IVF can display higher chances of cerebral palsy. Most of these risks are explained during the consultation.
    • Vaginal infections during pregnancy can increase inflammation due to the secretion of certain cytokines and other proteins; which may circulate in the blood and degenerate other organs as well. This may increase the chances of cerebral palsy.
    • Jaundice or acute cholestasis during pregnancy can increase the chances of premature birth; thereby increasing the risk of cerebral palsy.
    • Mothers with thyroid problems, intellectual disability, or seizures are at higher risk of having a child with cerebral palsy.
    • Other birth complications like detachment of the placenta, uterine rupture, and problems with the umbilical cord during birth may disrupt the oxygen supply to the baby causing severe brain damage and/or cerebral palsy.
    SUPPORTIVE THERAPY

    Studies have indicated that stem cell-induced brain plasticity is very crucial to regulating the pathophysiology of damaged brain and the treatment of cerebral palsy. This feature has directed us towards functional recoveries and rehabilitation therapies that aim to capitalize on optimum physical, sensory, intellectual, psychological as well as social functioning. We believe in Bobath Approach which is also known as neurodevelopmental treatment and is developed by Bobath in the 1940s; and has been acknowledged by industry experts for accurate assessments and effectiveness.

    Strength Training
    Strength Training

    Sensory Integration
    Sensory Integration

    Endurance Training
    Endurance Training

    Hyperbaric Oxygen Therapy
    Hyperbaric Oxygen Therapy

    Diet Education and Counselling
    Diet Education and Counselling

    Hydrotherapy
    Hydrotherapy

    TESTIMONIAL

    We have effectively used stem cell therapy and exosome technology to provide successful therapy to our patients dealing with cerebral palsy. Check out some of our successful cerebral palsy testimonials and improvements witnessed by our patients:

    • Thermishaa Soman, 4 year old Cerebral Palsy with Cortical Visual Impairment

      Thermishaa was born on 4th December 2013, as a normal full term baby. When she was 11 months old, her mom noticed that Thermishaa was not as active as the other children of her age would be! At the specified age, Thermishaa was not hitting any milestones, which…

    • Martin Marinov, Cerebral Palsy Patient Treatment Story

      Martin Marinov is a 5 year old child from Bulgaria who was delivered as a preterm baby and suffered asphyxia during childbirth. Unfortunately, the loss of oxygen for a few precious seconds resulted in some brain damage to the child leading to a condition known as…

    • Jona Ghelli, 16 years, Cerebral Palsy

      Home Country: Holliston, Massachusetts, USA Diagnosis Jona Ghelli, a 16-year-old, was diagnosed with cerebral palsy and microcephaly which results in significant cognitive and physical impairments. She also suffers from a seizure disorder. Microcephaly is a…

    IMPROVEMENTS

    Since stem cells can rejuvenate and differentiate into a variety of cell types, stem cells have the potential to manage various neurological conditions including cerebral palsy. A lot of evidence from pre-clinical and clinical research suggests the efficacy of stem cell therapy for cerebral palsy:

    Worldwide Clinical Studies using Stem Cells obtained from different sources

    Improvement in clinical signs and symptoms

    Must Read Articles on Cerebral Palsy

    What You Should Know About Athetoid Cerebral Palsy?
    What You Should Know About Athetoid Cerebral Palsy?

    The movement disorder athetoid cerebral palsy (also widely recognized as "dyskinetic cerebral palsy") is associated with damage to the developing brain. Children with athetoid CP experience hypertonia and hypotonia. The term hypertonia refers to abnormally high muscle...

    Stem Cell Therapy has Potential to Cure Cerebral Palsy
    Stem Cell Therapy has Potential to Cure Cerebral Palsy

    Cerebral palsy is a collective term for disorders resulting from perinatal brain injury. Cerebral palsy can also be caused by other factors like premature birth, uterus infection, lack of nutritional support and oxygen during development, and genetic aberrations.

    Statistics of 0verall Improvement of Cerebral Palsy Disease through Stem Cell Therapy

    Cerebral Palsy is an umbrella term for multiple brain disorders, resulting in the prenatal brain injuries and leading to multiple neuro-motor deficits, often accompanied by other visual and cognitive impairments. Although, conventional medicine fails to target the root cause of development, Stem Cell Therapy has shown great promise and heralds a potential revolution in medicine by offering new therapies that serve as a magic bullet to alleviate all clinical symptoms.

    We agree that each individual is different and needs special treatment and care. In today’s era of personalized medicine, this prospective approach has been beneficial for 70-80% of the patients, who have undergone Stem Cell Therapy at Advancells.

    Download the brochure to understand in depth knowledge about cerebral palsy.

    Recent Testimonials for Cerebral Palsy

    Over the last decade, developmental neurobiology has advanced at a tremendous speed, largely through preclinical as well as clinical investigations. This has further confirmed the role of stem cells in regulation and managing the symptomatic expression. The meta-analysis of data available from all ongoing and completed clinical studies across the world have acknowledged that 70-80% patients suffering from different types of cerebral palsies have shown improvements with Stem Cell Therapy. The number is significant enough to mark it as a positive initiation towards eventually taming or, at the very least, bringing Palsies to the manageable levels.

    Find out how the science of regenerative medicine and Stem Cell Therapy is improving the lives of those suffering with cerebral palsies.

    FAQs

     
    Advancells is a strong advocate of greater transparency in medical procedures in general and Stem Cells Procedures in particular. As a part of our effort of bringing transparent procedures to our clients, we provide each client a Third Party Certificate (from an internationally accredited lab) for the cell count and viability of the cells that we are able to process from the autologous cell source of the patient. To view the sample copy of the certificate  click here

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