The upper as well as lower jawline always play an essential role in chewing, speech, diction as well as cosmetic forms. Mandibles are the bones that are responsible for constructing strong peripheral boundaries of the mouth floor; for appropriate tongue positioning as well as jaw elevation to achieve easy swallowing, chewing as well as distinguished nasal structures. Thus, destruction of maxillary as well as mandibular structures can lead to functional as well as cosmetic form disruption of the tissue.
Thus, if you are one of those millions of people, suffering with misaligned or dysfunctional jaw lines; your dentist, orthodontist and/or oral surgeons might have spoken with you; about jawline reconstruction. Since there are multiple treatment options available, choosing the one that suits you can be a very hard decision. However, present available therapies like bone grafting, corrective surgeries can have multiple setbacks like cost of treatment, longer recovery period, procedural discomforts, etc.; whereas, advances in dental research and science of regenerative medicine can offer more advanced treatment options that are naturally effective. They can exploit biocompatible material in combination with constant supply of growth factors in order to stimulate reparative tissue regeneration.
In this regard, we have adapted a multidisciplinary approach towards engineering oral tissues, in order to build complex structures like bone, teeth, as well as soft dental tissues related to maxillary as well as mandibular origin; through systemic integration of stem cells population isolated from various sources of oral cavities. Our technology further involves novel application of biocompatible scaffolds to be able to provide chemical as well as mechanical cues to promote multiple cellular interactions, orchestrate important cellular processes, such as cellular adhesion, migration, growth, differentiation as well as vasculogenesis.
Accordingly, some indications that may denote a need for reconstructive treatment of Maxillary and/or Mandibular Jawline include:
Difficulty in swallowing, chewing or biting of food.
Chronic jaw and/or Jaw joint pain and headache.
Chronic mouth breathing or dry mouth.
Immoderate wear to teeth.
Inequitable facial appearance.
Birth Defects or facial injuries
Results of Jawline reconstruction through Dental Pulp derived Stem Cells and Biodegradable Scaffolds.
Although, orthognathic reconstruction through regenerative medicine is a novel technique; the conceptualization and early animal as well as preclinical studies have been around for last couple of years. Due to scientific advancements, continuing modernization of instrumentation as well as relative technical expertise; the elective treatment of a patient with this form of a procedure has been acknowledged as more safe, comfortable and reliable option, over the conventional forms. Procedures, that once demanded nearly more than ten hours of surgery can now be shortened to as little as two-three hours; with the help of this latest technology. Hospitalization post-surgery that would often necessitate more than five days of stay as an inpatient and may have involved a couple of day in the intensive care unit, can now be a one day affair.
This may be the reason why once recognized as an occasional surgery to which only the most grotesque deformities were relegated for treatment; the procedure has evolved as the most commonplace event, due to its predictable and stable treatment outcome.
Whether the mandibular or palatomaxillary defects are resultant of trauma, congenital deformity, or tumor formation; the introduction of autologous stem cells, from oral cavity can be emphasized on a nanostructured, suitably tested, compatible material to allow tailored jaw reconstruction for reestablishing the mechanics of mastication. In this regard, the site, size and associated soft tissue defects represent the three most important factors; in determining the impact of treatment procedure on functional restoration and aesthetics.
Our process of maxillary and/or mandibular jawline reconstruction involves three key elements, which include:
Inductive soluble growth factors
Stem cells isolated from dental pulp tissue
Biocompatible scaffolds made up of Xeno/Allo/Synthetic substitutes
Accordingly, steps involved in the procedures are:
Step 1- Qualification For The Treatment
A safety and efficacy assessments will be prescribed by our experts in order to investigate a degree of severity and a need to undergo particular treatment. Following pretreatment assessments can be suggested.
Infectious Disease Testing
Medical Reports & History
Panorex X Rays
Cephalometric X Rays
Models & Impressions
As per the results, the patient will be further counselled for final treatment that will impact proper jaw functions and an aesthetic appearance of an entire face.
Step 2- Source Extraction
Mesenchymal stem cells and/or neural crest derived stem cells isolated from soft tissue of the wisdom tooth has been confirmed to be the most potent, non-invasive source of stem cells with high proliferation rate, higher degree of differentiation and a better capacity to interact with biocompatible matrices and growth factors for faster regeneration and healing.
Thus, Dental Pulp stem cells sourced from either wisdom tooth or milk tooth, that are already planned to remove will be collected as a better fitting tool due to easy access, and a very low morbidity of the anatomical site.
Step 3- Laboratory Processing
Tissue samples containing stem cells will be transported to our ultramodern GMP grade facility, through placing it, in a screw top vial containing appropriate transportation media; which may nourish it during transportation. Mesenchymal stem cells and/or neural crest derived stem cells will be isolated from a soft dental pulp tissue, which is encased inside a bony cavity of wisdom tooth or milk tooth; under controlled sterile conditions.
Step 4- Stem Cell Implantation
Expanded stem cells will be loaded on a suitable matrix called as scaffold to allow speedy attachment, faster regeneration into specific cell types and easy proliferation. Although scaffolds are of different types, shapes, patterns as well as biocompatible materials; depending upon the necessity, capacity and costing it can be made up of Xeno/Allo/Synthetic substitute.
Tissue Reconstruction through Biodegradable Scaffolds: - We have wide range of ideal scaffolds made up of different biocompatible materials, to provide chemical stability, physical strength and mimicking the surrounding tissue with respect to faster cellular proliferation, better adhesion performance, controlled degradation, easy differentiation and better integration.
A scaffold will further be implanted and secured in a position above and/or below jawline; depending upon the clinical condition to allow faster reconstruction and speedy healing of jawbones.
Step 5- Maintenance & Follow Up
Following the completion of implants, patients are advised to thoroughly clean around the implants as instructed by our dental hygienist. Patients will be called for the regular review so that the health and the integrity of the soft tissues and other bones can be evaluated.
Orthodontics is a specialized branch of dentistry, which specializes in the diagnosis, prevention and treatment of dental, facial and other craniofacial irregularities. Orthodontists or dental specialists have acquired specialized training and education in using different types of materials and technology to implement these corrective measures.
What are the different signs for orthodontic treatment?
Early or late loss of baby teeth
Difficulty in chewing and/or biting
Joints that make sounds
Overbite and/or Underbite
Excessive spaces between the teeth
What are different craniofacial issues, that need immediate treatment?
A craniofacial region is primarily comprised of a framework of bones and cartilages, giving support to muscles, ligaments, glands and various other soft tissues, including skin and subcutaneous layers. Apparently, all these elements are innervated by the bodyâ€™s most sophisticated neurovascular network, allowing for its complete functional as well as sensorial capabilities. Various injuries caused as a result of trauma, tumor, cyst development, infectious disease spreading and/or congenital as well as other developmental conditions may result into serious functional, aesthetic as well as psychological sequelae.
In this regard, structural loss of hard and soft tissues can be often disfiguring and compromising; thus, hampering basic functions, like mastication, speech, swallowing and also in thermal and physical protection.
How stem cells therapy can be useful in undergoing Craniofacial Tissue Regeneration?
Stem cells are known to be the most potent cells in our body with the ability to retain their number back, through mitotic cell division and can undergo directed differentiation into variety of other specialized cells. Mesenchymal stem cells isolated from dental pulp tissue are found to be very helpful in guided tissue regeneration in the craniofacial cavity. However, it has as well been very apparent in different bench side studies that stem cells behavior and differentiation ability can be enhanced significantly through generation of suitable three-dimensional microenvironment. This microenvironment can be constructed through biomimetic scaffolds made up of All/Xeno/Auto substitutes in order to enhance and speed up the process of tissue reconstruction.
How long will it take to complete the treatment?
Being a very individualistic treatment, the total treatment time would obviously be dependent upon everyoneâ€™s specific problem with varied severity. In general, treatment time lasts from 8 months to 12 months.
What should I consider, while choosing an orthodontic specialist?
Since, every orthodontic procedure includes permanent structural and functional changes in teeth and other facial tissues; it is very important that the specialist should be experienced and well aware of the latest technology to achieve, appropriate and desired results. Moreover, an orthodontic specialist to be chosen, should have extensive and specialized knowledge and expertise to offer very professional and specialized treatment plans.
How much will the treatment cost?
Since, it is very difficult to accurately determine different treatment costs without clinically examining the patient; we would advise patients to undergo detailed consultation; wherein, we would assess the issue, through in person consultation, in order to evaluate the cost of treatment