Stem Cells for Muscular Dystrophies

Therapeutic effects of stem cells and stem cell-derived exosomes are linked with their ability to bring epigenetic changes and thereby promote regeneration of new cells with the enhanced genetic makeup to prevent muscle loss.

Exosomes loaded with therapeutic machinery can be an appropriate targeted delivery system.

Exosome Therapy
Muscular Testimonials
Result

Stem Cells for Duchenne Muscular Dystrophy Treatment

Muscular dystrophies are genetic conditions causing progressive wastage of muscles. Previous investigations have reported changing genetic dynamics to be responsible for the same. Unfortunately, with conventional medicine, muscular dystrophies always remain life-limiting. Once confined to the realm of science fiction, a combinational approach using stem cells along with their exosomes is effective in making a real difference to the quality of life of many patients.

Stem Cell Treatment for Muscular Dystrophy: Advancells Protocol

Muscular dystrophy, a heterogeneous group of neuromuscular disorders, manifests a progressive wastage of muscles; accounting for their weakness, steady functional loss, and in many cases death. Although there has been a tremendous understanding of underlying molecular pathways, there has been no cure in conventional medicine. However, due to technological advancements, several alternative therapeutic options have been suggested by the scientific world after thorough investigations at the laboratory, preclinical sites, and clinical studies. These encouraging experiments further demonstrated that pluripotent mesenchymal stem cells along with their exosomes when transplanted into dystrophic muscles; can repair a small portion of damaged muscle fibers. Studies have also pinpointed that exosomes isolated from mesenchymal stem cells when administered together can promote epigenetic changes, and redirect genes to stop synthesizing damaging muscle protein to reduce further progression. A lot of further research is ongoing and is necessary to make stem cell therapy for muscular dystrophies a viable treatment option.

Procedure for treatment of Muscular Dystrophies using Stem cells

Treatment Qualification

Source Extraction

Processing of stem cells

Re-infusion

MUSCULAR DYSTROPHY THERAPY

STEM CELLS PROCEDURE

MUSCULAR DYSTROPHY RESULTS

The muscle resident stem cells, also known as the “Satellite cells” are precursors giving rise to healthy muscle cells; and are present in the niche in their quiescent state in their Go reversal mode. The stimulation of these satellite cells can promote the production of new active muscle cells, in response to tissue injury. The differentiation capacity of mesenchymal stem cells is demonstrated and is found to be the key to treating many different types of dystrophies, such as:

Frequent Falls

Wadding Gait

Large Calf Muscles

Delayed Growth

Muscle Pain

Stiffness

Frequent Fall

Walking on the Toes

Learning Disabilities

Delayed Milestone

Large Calf Muscles

Muscle Pain/Stiffness

Frequent Muscle Stiffness

Muscle Pain in Facial and Neck Muscles

Long, Thin Faces

Drooping Eyelids

Swanlike Necks

Learning Disabilities

Hip/Shoulder Muscles are Affected

Muscle Pain

Stiffness

Difficulty in Lifting the Front Part of the Foot

Frequent Falls

Muscle Stiffness

Facial Muscle Weakness

Progressive Wastage in Hip Muscles

Muscle Pain/Stiffness

Abnormal Appearance of Shoulder Blade Muscles

Drooping Eyelids

Reduced Efficiency of Heart Muscles

The type of dystrophy is identified to be due to genetic mutations, producing a faulty protein that damages muscle fibers. Each type of muscular dystrophy is caused due to genetic mutation particular to that type of indication. Normally the gene defect is inherited, but they can also come from spontaneous mutation.

CAUSES OF
MUSCULAR DYSTROPHIES

Protein deficiency in the mothers
Autosomal dominant inherited disorders, inheriting the faulty gene from just one parent
Autosomal recessive inherited disorders, inheriting the gene from both the parents
The inheritance of the faulty gene through the X chromosome
Spontaneous mutations through the environment
Maternal age during pregnancy

Certain forms of muscle therapy have proven to be useful, including post-stem cells and exosome infusion. These techniques demand working with experts to provoke the right quantity of stem cells to reach the targeted locations, stimulate resident stem cells, and promote regeneration to a better extent. Accordingly, Advancells proposes a series of rehabilitation programs to get symptomatic relief in muscular dystrophies and lead a good quality of life.

Genetic deficiency of dystrophin leads to functional muscle loss, muscle wastage, and other disabilities. No complete cure is available in conventional medicine for muscular dystrophies; however, various supportive treatments can help ease the lifelong complications. Studies have suggested a combinational approach, wherein stem cells along with exosomes are administered directly in muscles to promote the regeneration of lost muscle fibers. During our clinical analysis, we observed that

Worldwide Clinical Studies using Stem Cells obtained from different sources

60% people have reported increased survival functions on an average with 87.76 months

40% of the patient reported reduced muscle pain and stiffness post stem cell therapy
50% of the patients reported reduced flares of muscle stiffness
60% of the patients gained prominent control over their weakened muscles.
30-40% have shown improvement in their walking patterns
20-30% of the patients have reported good psycho-social mental balance

With the administration of stem cells and exosomes, the primary goal is to offer speedy recovery, reduce the level of inflammation and regain functional attributes lost.

Akhil, Muscular Dystrophy

Akhil DOB: 23/04/75 Date of Treatment 8/10/2013 Akhil has been suffering from muscular dystrophy. He was a challenging case as the patient had fibrosis tumors all over spine and body. As a result his spine was very weak and a aspiration of BM was a difficult…
Ali Mohammed, 25 years, Muscular Dystrophy

Year of birth: 7th March 1992 I had been diagnosed with a degenerative condition a decade ago, which is marked as the beginning of my muscular weakening and progressive muscle damage. Initially, I had experienced frequent falls, which forced us to meet an orthopedist;…

READ MUSCULAR DYSTROPHY SUCCESS STORIES

TYPES OF MUSCULAR DYSTROPHIES

The muscle resident stem cells, also known as the “Satellite cells” are precursors giving rise to healthy muscle cells; and are present in the niche in their quiescent state in their Go reversal mode. The stimulation of these satellite cells can promote the production of new active muscle cells, in response to tissue injury. The differentiation capacity of mesenchymal stem cells is demonstrated and is found to be the key to treating many different types of dystrophies, such as:

DUCHENNE MUSCULAR DYSTROPHIES

BECKER MUSCULAR DYSTROPHIES

MYOTONIC MUSCULAR DYSTROPHIES

LIMB-GIRDL MUSCULAR DYSTROPHIES

Hip and Shoulder Muscles are Affected — Hip/Shoulder Muscles are Affected

CAUSES OF MUSCULAR DYSTROPHIES

The type of dystrophy is identified to be due to genetic mutations, producing a faulty protein that damages muscle fibers. Each type of muscular dystrophy is caused due to genetic mutation particular to that type of indication. Normally the gene defect is inherited, but they can also come from spontaneous mutation.

CAUSES OF
Muscular Dystrophy

Protein deficiency in the mothers
Autosomal dominant inherited disorders, inheriting the faulty gene from just one parent
Autosomal recessive inherited disorders, inheriting the gene from both the parents
The inheritance of the faulty gene through the X chromosome
Spontaneous mutations through the environment
Maternal age during pregnancy

SUPPORTIVE THERAPY

Certain forms of muscle therapy have proven to be useful, including post-stem cells and exosome infusion. These techniques demand working with experts to provoke the right quantity of stem cells to reach the targeted locations, stimulate resident stem cells, and promote regeneration to a better extent. Accordingly, Advancells proposes a series of rehabilitation programs to get symptomatic relief in muscular dystrophies and lead a good quality of life.

Dietary Modification — Respiratory Therapy

OUTCOMES

Since stem cells can rejuvenate and differentiate into a variety of cell types, stem cells have the potential to manage various neurological conditions including cerebral palsy. A lot of evidence from pre-clinical and clinical research suggests the efficacy of stem cell therapy for cerebral palsy:

Worldwide Clinical Studies using Stem Cells obtained from different sources

Improvement in clinical signs and symptoms

40% of the patient reported reduced muscle pain and stiffness post stem cell therapy
50% of the patients reported reduced flares of muscle stiffness
60% of the patients gained prominent control over their weakened muscles.
30-40% have shown improvement in their walking patterns
20-30% of the patients have reported good psycho-social mental balance

TESTIMONIAL

With the administration of stem cells and exosomes, the primary goal is to offer speedy recovery, reduce the level of inflammation and regain functional attributes lost.

Akhil, Muscular Dystrophy
Akhil DOB: 23/04/75 Date of Treatment 8/10/2013 Akhil has been suffering from muscular dystrophy. He was a challenging case as the patient had fibrosis tumors all over spine and body. As a result his spine was very weak and a aspiration of BM was a difficult…
Ali Mohammed, 25 years, Muscular Dystrophy
Year of birth: 7th March 1992 I had been diagnosed with a degenerative condition a decade ago, which is marked as the beginning of my muscular weakening and progressive muscle damage. Initially, I had experienced frequent falls, which forced us to meet an orthopedist;…

READ MUSCULAR DYSTROPHY SUCCESS STORIES

Must Read Articles on Muscular Dystrophy

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Meta-analysis of Muscular Dystrophies using stem cells

Stem cell therapy for Muscular Dystrophy

Many studies completed using mesenchymal stem cells from a variety of accessible resources have demonstrated the safety and feasibility potential of transplanted stem cells; which can not only promote regeneration of myofibres, with the activation of satellite cells. Certain studies have also confirmed that stem cells, when transplanted directly into the human body can repopulate in stem cell niche present in the muscles to promote cellular regeneration. Data from previous studies
(NCT02196467) have supported higher expression of myofibers, and robust levels of dystrophin expression. The studies led to further optimization of the number and source of stem cells to be effective.

Download the brochure to understand in depth knowledge about Muscular Dystrophy.

FAQs

What is Muscular Dystrophy and can stem cells help?

MD's are a group of disorders characterized by hereditary defects in muscle protein, the death of muscle cells and muscular weakness. Mutations in genes, involved in muscular membrane structure and function can also welcome the deformity. Theoretically, if stem cells are injected into the body, they can produce normal muscle cells which are non-functional due to faulty genes. Some kind of stimulation can also be helpful to multiply the residential stem cells and differentiate on their own to muscle cells.

How can stem cells be beneficial to treat Muscular Dystrophy?

Undifferentiated adult autologous stem cells are mutable and can Metamorph into countless numbers of cells as per the requirement. This remarkable property of stem cells can be exploited for treating a variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with greater speed to promote regeneration of muscular cells, to help control over your mood swings, to improve the physical fitness and overall mobility. Additionally, a stimulation therapy can also be applied, wherein the organ is stimulated to multiply the resident stem cells and secrete growth factors to create microenvironment. This treatment will act as a booster to promote regeneration.

Why is stem cell treatment better than conventional treatment approach in treating Muscular Dystrophy?

The conventional treatment approach is highly invasive and associated with many side effects. Although stem cells can naturally heal the body from damage and regenerate lost tissue-specific cells to improve impaired functions. Additionally, since the body's own cells are used for repairing, the entire treatment is minimally invasive without any side effects.

What are the different stem cells that can offer help for Muscular Dystrophy?

Stem cells transplantation is of different types ranging from allogeneic mesenchymal stem cells, umbilical cord blood-derived stem cells, autologous bone marrow and fat-derived stem cells, etc. However, out of these, autologous mode of stem cell transplantation is known to be the most useful as body's own cells are used they don't impose any threat of rejection of infection.