Stem Cell Therapy for Muscular Dystrophies

Therapeutic effects of stem cells and stem cell-derived exosomes are linked with their ability to bring epigenetic changes and thereby promote regeneration of new cells with the enhanced genetic makeup to prevent muscle loss.

Exosomes loaded with therapeutic machinery can be an appropriate targeted delivery system.

Stem Cell Treatment for Dystrophies & Duchenne Muscular Dystrophy

Muscular dystrophies are genetic conditions causing progressive wastage of muscles. Previous investigations have reported changing genetic dynamics to be responsible for the same. Unfortunately, with conventional medicine, muscular dystrophies always remain life-limiting. Once confined to the realm of science fiction, a combinational approach using stem cells along with their exosomes is effective in making a real difference to the quality of life of many patients.

Stem Cell Therapy for Muscular Dystrophy: Advancells Protocol

Muscular dystrophy, a heterogeneous group of neuromuscular disorders, manifests a progressive wastage of muscles; accounting for their weakness, steady functional loss, and in many cases death. Although there has been a tremendous understanding of underlying molecular pathways, there has been no cure in conventional medicine. However, due to technological advancements, several alternative therapeutic options have been suggested by the scientific world after thorough investigations at the laboratory, preclinical sites, and clinical studies. These encouraging experiments further demonstrated that pluripotent mesenchymal stem cells along with their exosomes when transplanted into dystrophic muscles; can repair a small portion of damaged muscle fibers. Studies have also pinpointed that exosomes isolated from mesenchymal stem cells when administered together can promote epigenetic changes, and redirect genes to stop synthesizing damaging muscle protein to reduce further progression. A lot of further research is ongoing and is necessary to make stem cell therapy for muscular dystrophies a viable treatment option.

Procedure for treatment of Muscular Dystrophies using Stem cells

Treatment Qualification

Source Extraction

Processing of stem cells

Re-infusion

The muscle resident stem cells, also known as the “Satellite cells” are precursors giving rise to healthy muscle cells; and are present in the niche in their quiescent state in their Go reversal mode. The stimulation of these satellite cells can promote the production of new active muscle cells, in response to tissue injury. The differentiation capacity of mesenchymal stem cells is demonstrated and is found to be the key to treating many different types of dystrophies, such as:
Frequent Falls
Frequent Falls
Wadding Gait
Wadding Gait
Large Calf Muscles
Large Calf Muscles
Delayed Growth
Delayed Growth
Muscle Pain
Muscle Pain
Stiffness
Stiffness
Frequent Fall
Frequent Fall
Walking on the Toes
Walking on the Toes
Learning Disabilities
Learning Disabilities
Delayed Milestone
Delayed Milestone
Large Calf Muscles
Large Calf Muscles
Muscle Pain or Stiffness
Muscle Pain/Stiffness
Frequent Muscle Stiffness
Frequent Muscle Stiffness
Muscle Pain in Facial and Neck Muscles
Muscle Pain in Facial and Neck Muscles
Long and Thin Faces
Long, Thin Faces
Drooping Eyelids
Drooping Eyelids
Swanlike Necks
Swanlike Necks
Learning Disabilities
Learning Disabilities
Hip/Shoulder Muscles are Affected
Hip/Shoulder Muscles are Affected
Muscle Pain
Muscle Pain
Stiffness
Stiffness
Difficulty in Lifting the Front Part of the Foot
Difficulty in Lifting the Front Part of the Foot
Frequent Falls
Frequent Falls
Muscle Stiffness
Muscle Stiffness
Facial Muscle Weakness
Facial Muscle Weakness
Progressive Wastage in Hip Muscles
Progressive Wastage in Hip Muscles
Muscle Pain or Stiffness
Muscle Pain/Stiffness
Abnormal Appearance of Shoulder Blade Muscles
Abnormal Appearance of Shoulder Blade Muscles
Drooping Eyelids
Drooping Eyelids
Reduced Efficiency of Heart Muscles
Reduced Efficiency of Heart Muscles
The type of dystrophy is identified to be due to genetic mutations, producing a faulty protein that damages muscle fibers. Each type of muscular dystrophy is caused due to genetic mutation particular to that type of indication. Normally the gene defect is inherited, but they can also come from spontaneous mutation.
Causes-of-muscular-dystrophies

CAUSES OF
MUSCULAR DYSTROPHIES
  • Protein deficiency in the mothers
  • Autosomal dominant inherited disorders, inheriting the faulty gene from just one parent
  • Autosomal recessive inherited disorders, inheriting the gene from both the parents
  • The inheritance of the faulty gene through the X chromosome
  • Spontaneous mutations through the environment
  • Maternal age during pregnancy
Certain forms of muscle therapy have proven to be useful, including post-stem cells and exosome infusion. These techniques demand working with experts to provoke the right quantity of stem cells to reach the targeted locations, stimulate resident stem cells, and promote regeneration to a better extent. Accordingly, Advancells proposes a series of rehabilitation programs to get symptomatic relief in muscular dystrophies and lead a good quality of life.
Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy By creating hypoxia in the brain, due to rising atmospheric pressure; HBOT helps to direct infused stem cells to reach the targeted locations at a faster rate. The therapy has been very effective if taken immediately post stem cell infusion.
Physiotherapy
PhysiotherapyPhysiotherapy helps people maintain muscle functions by managing complications like joint contractures, cardiovascular strength, frequent falls, etc. Regular sessions can help increase jointflexibility and delay developmental contractures.
Speech Therapy
Speech TherapyIt helps conserve muscle strength through the integration of specific techniques like shower speech, pausing between breaths, etc.
Occupational Therapy
Occupational Therapy It is a process, focusing on daily activity to help those with muscular dystrophy become more independent, gain access to community services and improve coping skills
Corticosteroid drug treatment
Corticosteroid drug treatmentHelps strengthen muscle functions and promotes slow muscle deterioration.
Occupational Therapy
Respiratory TherapyA detailed program guided by experts can help maintain good respiratory strength. Certain
respiratory therapists can design integration of excellent breathing exercises to prevent or delay breathing problems.

Genetic deficiency of dystrophin leads to functional muscle loss, muscle wastage, and other disabilities. No complete cure is available in conventional medicine for muscular dystrophies; however, various supportive treatments can help ease the lifelong complications. Studies have suggested a combinational approach, wherein stem cells along with exosomes are administered directly in muscles to promote the regeneration of lost muscle fibers. During our clinical analysis, we observed that

Worldwide Clinical Studies using Stem Cells obtained from different sources

60% people have reported increased survival functions on an average with 87.76 months

With the administration of stem cells and exosomes, the primary goal is to offer speedy recovery, reduce the level of inflammation and regain functional attributes lost.

  • Akhil, Muscular Dystrophy

    Akhil DOB: 23/04/75 Date of Treatment 8/10/2013 Akhil has been suffering from muscular dystrophy. He was a challenging case as the patient had fibrosis tumors all over spine and body. As a result his spine was very weak and a aspiration of BM was a difficult…

  • Ali Mohammed, 25 years, Muscular Dystrophy

    Year of birth: 7th March 1992 I had been diagnosed with a degenerative condition a decade ago, which is marked as the beginning of my muscular weakening and progressive muscle damage. Initially, I had experienced frequent falls, which forced us to meet an orthopedist;…

Muscular Dystrophy Testimonials
TYPES OF MUSCULAR DYSTROPHIES

The muscle resident stem cells, also known as the “Satellite cells” are precursors giving rise to healthy muscle cells; and are present in the niche in their quiescent state in their Go reversal mode. The stimulation of these satellite cells can promote the production of new active muscle cells, in response to tissue injury. The differentiation capacity of mesenchymal stem cells is demonstrated and is found to be the key to treating many different types of dystrophies, such as:


Frequent Falls
Frequent Falls

Wadding Gait
Wadding Gait

Large Calf Muscles
Large Calf Muscles

Delayed Growth
Delayed Growth

Muscle Pain
Muscle Pain

Stiffness
Stiffness


Frequent Fall
Frequent Fall

Walking on the Toes
Walking on the Toes

Learning Disabilities
Learning Disabilities

Delayed Milestone
Delayed Milestone

Large Calf Muscles
Large Calf Muscles

Muscle Pain or Stiffness
Muscle Pain/ Stiffness


Frequent Muscle Stiffness
Frequent Muscle Stiffness

Muscle Pain in Facial and Neck Muscles
Muscle Pain in Facial and Neck Muscles

Long and Thin Faces
Long, Thin Faces

Drooping Eyelids
Drooping Eyelids

Swanlike Necks
Swanlike Necks

Learning Disabilities
Learning Disabilities


Hip and Shoulder Muscles are Affected
Hip/Shoulder Muscles are Affected

Muscle Pain
Muscle Pain

Stiffness
Stiffness

Difficulty in Lifting the Front Part of the Foot
Difficulty in Lifting the Front Part of the Foot

Frequent Falls
Frequent Falls

Muscle Stiffness
Muscle Stiffness

CAUSES OF MUSCULAR DYSTROPHIES
The type of dystrophy is identified to be due to genetic mutations, producing a faulty protein that damages muscle fibers. Each type of muscular dystrophy is caused due to genetic mutation particular to that type of indication. Normally the gene defect is inherited, but they can also come from spontaneous mutation.

CAUSES OF
Muscular Dystrophy
Causes of Muscular Dystrophy Treatment
  • Protein deficiency in the mothers
  • Autosomal dominant inherited disorders, inheriting the faulty gene from just one parent
  • Autosomal recessive inherited disorders, inheriting the gene from both the parents
  • The inheritance of the faulty gene through the X chromosome
  • Spontaneous mutations through the environment
  • Maternal age during pregnancy
SUPPORTIVE THERAPY

Certain forms of muscle therapy have proven to be useful, including post-stem cells and exosome infusion. These techniques demand working with experts to provoke the right quantity of stem cells to reach the targeted locations, stimulate resident stem cells, and promote regeneration to a better extent. Accordingly, Advancells proposes a series of rehabilitation programs to get symptomatic relief in muscular dystrophies and lead a good quality of life.

Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy

Physiotherapy
Physiotherapy

Speech Therapy
Speech Therapy

Occupational Therapy
Occupational Therapy

Corticosteroid drug treatment
Corticosteroid drug treatment

Dietary Modification
Respiratory Therapy

OUTCOMES

Since stem cells can rejuvenate and differentiate into a variety of cell types, stem cells have the potential to manage various neurological conditions including cerebral palsy. A lot of evidence from pre-clinical and clinical research suggests the efficacy of stem cell therapy for cerebral palsy:

Worldwide Clinical Studies using Stem Cells obtained from different sources

Improvement in clinical signs and symptoms
TESTIMONIAL

With the administration of stem cells and exosomes, the primary goal is to offer speedy recovery, reduce the level of inflammation and regain functional attributes lost.

Muscular Dystrophy Testimonials
  • Akhil, Muscular Dystrophy

    Akhil DOB: 23/04/75 Date of Treatment 8/10/2013 Akhil has been suffering from muscular dystrophy. He was a challenging case as the patient had fibrosis tumors all over spine and body. As a result his spine was very weak and a aspiration of BM was a difficult…

  • Ali Mohammed, 25 years, Muscular Dystrophy

    Year of birth: 7th March 1992 I had been diagnosed with a degenerative condition a decade ago, which is marked as the beginning of my muscular weakening and progressive muscle damage. Initially, I had experienced frequent falls, which forced us to meet an orthopedist;…

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Muscular Dystrophy Types, Symptoms, Diagnosis And Treatment
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Cell Treatment – Effective For Duchenne Muscular Dystrophy (DMD)
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Meta-analysis of Muscular Dystrophies using stem cell therapy

Many studies completed using mesenchymal stem cells from a variety of accessible resources have demonstrated the safety and feasibility potential of transplanted stem cells; which can not only promote regeneration of myofibres, with the activation of satellite cells. Certain studies have also confirmed that stem cells, when transplanted directly into the human body can repopulate in stem cell niche present in the muscles to promote cellular regeneration. Data from previous studies
(NCT02196467) have supported higher expression of myofibers, and robust levels of dystrophin expression. The studies led to further optimization of the number and source of stem cells to be effective.

FAQs

 
Advancells is a strong advocate of greater transparency in medical procedures in general and Stem Cells Procedures in particular. As a part of our effort of bringing transparent procedures to our clients, we provide each client a Third Party Certificate (from an internationally accredited lab) for the cell count and viability of the cells that we are able to process from the autologous cell source of the patient. To view the sample copy of the certificate  click here

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