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Stem cell therapy for Orthopaedics

Stem Cell Treatment For Knees

If you have encountered any of the issues, related to injuries as well as chronic pain associated with knees, legs, cartilages, ACL/MCL ligaments, due to diseased conditions, like:

  • Osteoarthritis
  • Rheumatoid Arthritis
  • Adolescent Anterior Knee Pain
  • Bowed Legs ( Blount’s Disease)
  • Compartment Syndrome
  • Deep Vein Thrombosis
  • Osgood Schlatter Disease
  • Sciatic Nerve Injuries
  • Osteonecrosis
  • Shin Splints
  • Bursitis
  • Meniscus tear

For chronic pain, stiffness and functional loss of these tissues, conventionally knee replacement and/or surgery was the only recommended option. However, as with most of the surgical procedures, knee surgeries as well exhibit certain risks, like opportunistic infections, rejection by the body, longer recovery periods, cost, etc. Moreover, it may as well affect certain high impact activities; for these reasons, many patients have turned their minds to stem cell therapy as the safest alternative to knee replacement surgeries.

Pathophysiology of Knees

Stem cell therapy for osteoarthritis

As we all know, the primary tissue section that is been affected in the knee injuries, is the shock absorbing, cushioning material known to be cartilages. So, let us take a little time to explore in great details, what exactly cartilage is?

The main cell type found in the cartilage, which absorb as shock absorbing cushioning material is the chondrocytes. These cells are derived from progenitor cells called chondroblasts, which are trapped in the developing cartilage, between interspaces called as “Lacunae.” From here only these cells are nourished to produce all the required constituents like collagen, synovial fluid, etc. Unfortunately, these structural boundaries are making them unable to migrate to the areas of damage. This is further compromised by the presence of the cartilaginous matrix, acting as immune barriers, like lymphocytes and immunoglobulines, assisting in the healing process. Moreover, a lack of blood supply is associated with the delayed matrix formation, with the limited ability to recover from the insult.

Many of the knee issues are associated with the malfunctioning of the chondrocytes, forcing a change in 0its composition. This change further prevents production of large water retaining proteins, allowing a cartilage to dehydrate completely. This cracking of cartilage is termed as fissuring, which progressive prevents it from recovery.

It should be noted that in the early stage of the issue, the bone attempts to do all that it can; in fact, the body lays down more bone around the joint to strengthen the region. However, bone can never withstand any drastic insult as dealing with the repetitive load of joint movement and as such it fatigues. The result of this failure is unbearable pain.

Stem Cell Treatment

How does stem cell therapy work?

Adult stem cells can be recovered from our own body tissues, like adipose tissue/fat, which can be recovered in larger quantities and are allowed to differentiate inside the body. (In Vivo) In fact, adult forms of these stem cells are being stored in all mature organs and are poised to leap into the action to repair damage, which has occurred from day to day wear and tear of the body. However, as we age or have bigger issues as mentioned here with our body may not be able to recruit enough number of these biological adjutants to the desired location, to fully repair the area.

Advancells helps overcoming this problem by extracting stem cells from belly fat, an area with high stem cell numbers, then concentrating these mighty cells in the controlled environment and reinjecting into the damaged area, to allow natural regeneration of lost body parts.

Super concentrated Platelet Rich Plasma & Advanced Platelet Lysate Procedures

We are specialized our treatment protocol with stimulation technique; wherein we trigger your stem cells, with reach concentrate of growth factors, extracted from autologous blood. These laser activated stem cells, when infused into patient’s body, can immediately start signaling. These signals are being identified by the immune cells, which attract stem cells to the targeted areas.

Our advanced technology is more concentrate and a new improved version of traditional platelet rich plasma, with a whooping 99% success rate in all orthopedic conditions.

We understand the science behind stem cell therapy and hence try to offer a very comprehensive treatment protocol, with maximum recovery.

Our procedure can be divided into

Step 1- Qualification For The Treatment

Pre-Treatment Assessments

Pre-Operative Procedure

As per these results, the patient will be counseled further for final decision of protocol.

Step 2- Source Extraction

On the basis of consultation and requirement, a source of stem cells will be decided. On a generalized note patient will be prescribed autologous extraction of body’s own stem cells; however, in certain conditions, the procedure can be little diverted from its path, for a better outcome.

Sample extraction can be done from the patient, on the specified date and time; with the application of local anesthesia. The entire procedure takes around 7-8 hours; however, in case of certain conditions like patient has to be with us for little longer period of time.

If you are still curious to know more about the procedure, kindly refer our detailed snapshot below:

Stem cell therapy procedure for Orthopaedic

Step 3- Laboratory Processing

The extracted sample will be dispatched to our regulatory compliant, cGMP authorized laboratory for processing. Advancells processing facility is a state of the art, class 10,000 clean room, equipped with all automated technology. Stem cells will be isolated from the source, processed further and revitalized with patient’s own plasma and laser stimulation for the quick repair and natural recovery.

Stem cells will be concentrated in injectable volumes, with minimum manipulation and will be characterized for their quality, purity and viability. For us, every client is precious and would like to maintain complete transparency between two of us, which is why we are providing third party certificate of quality, along with our Certificate of Analysis.

Step 4- Stem Cell Implantation

The enriched fraction of stem cells will be infused directly into the patient’s body through one of the modes of implantations, mentioned below.

Targeted Delivery: - Cells will be delivered directly at the site of injury; i.e. between the joints in case of knees, using guided imaging technology.



Orthopaedic Stem Cell Treatment Results

Ten patients mean age ≥ 45 years (Sex ratio; 2 male: 3 female) with chronic knee pain unresponsive to conservative treatments and radiologic evidence of degenerative arthritis were treated with autologous bone marrow stem cells by intra-articular injection (Read more...)

Patient's Stories

Ms. AS 33 Years Old Fibromyalgia

"It has almost been two months now, since I have undergone stem cells therapy; and I am having almsot 80% relief from pain, head ache and better quality of life."

Owen Cooke, 61 years, Osteoarthritis and Foot Damage

"Overall, I am very, very pleased with the result so far."

Malcolm Pasley, Osteoarthritis (Knee)

"I notice a huge improvement in both knees."

Robert Da Prato, 64 years, Osteoarthritis - Knees

"I am happy. Perhaps in a few more months, my situation will improve."

Wendy Funston, 57 years, Arthritis in Hands, Knees, Feet, Elbows

"Since treatment I HAVE BEEN PAIN FREE!!!!"



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Frequently Asked Questions

  • What is orthopaedics?
  • Orthopaedics the branch of science, focusing on injuries and diseases of the body's musculoskeletal system; including bones and muscles.
  • What is joint replacement surgery & how long it last?
  • Joint replacement surgery is performed to replace damaged joint with a new, artificial joint known as a Prosthesis. On an average, these joints have a lifespan of 10 years, however it varies depending upon the usage and person's age.
  • What is the difference between the sprain or strain?
  • A strain occurs when the muscle or tendon is stretched or torn. A sprain occurs when a ligament is stretched or torn.
  • What is Sciatica?
  • In our lower back, nerves join to form the Sciatic Nerve; which runs down in the leg and controls the muscles of the leg. Sciatica is the condition that may cause a radiatic pain, numbness, tingling and/or muscle weakness in the leg.
  • What is shoulder impingement?
  • Impingement syndrome, is a common disorder of the shoulder referring to an improper alignment of the bone and the tissues in the upper arm. Inflammatory conditions such as arthritis are closely related to the impingement syndrome.
  • What is the separated shoulder?
  • A shoulder separation occurs when the outer end of the collarbone separates from the end of the shoulder blades because of the torn ligaments. The injury occurs most often from a blow to the shoulders or stretched hand or arms.
  • Do men get osteoporosis?
  • Although osteoporosis is more common in women, atleast one in eight over 50 have the chances of getting osteoporosis. As with the declined testosterone levels in men can also lead to increased chances of the bone loss.
  • How can Osteoporosis be prevented?
  • Osteoporosis can be prevented by reaching the peak bone mass, during the childhood and teenage years. Few habits can be incorporated in order to increase bone mass such as enough calcium and vitamin D uptake by drinking milk and milk products, regular exercise, avoiding milk and milk products, avoiding smoking and excessive alcohol consumption.
  • Can stem cell treatment, reverse my damage?
  • Yes, stem cells are the pristine cells of the body, which can give rise to many different types of cells upon proper signalling. These cells have been exploited successfully to differentiate into neurogenic, osteogenic and chondrogenic lineages. They have been isolated from the very own potent sources of our body known as Bone Marrow and Adipose Tissues. They can be minimally manipulated and implanted back into the body to promote neuroregeneration, bone reconstruction, reformation of tendons and cartilages.
  • Where can I get more information about Disease?
  • Please go through, our treatment brochures for other Orthopaedics related information.


What can you expect?

Many patients after stem cell treatment reported to be exhibiting:

  • Inflammatory process activity decreases
  • Morning stiffness, joint tenderness, oedema is diminished
  • Patient's functional capacity has been improved tremendously
  • Considerable redevelopment of cartilaginous tissue observed from X-Ray analysis that can avoid further damage to the joints.
  • In most of the cases, complete discontinuation or considerable reduction of anti inflammatory drugs has been achieved.
  • Quality of life has been improved in patients achieving 100% target.
  • However, a complete restoration of the central nervous system, is the prolonged process and requires lots of patience and repetition of treatment if required or suggested.