If you have encountered any of the issues, related to injuries as well as chronic pain associated with knees, legs, cartilages, ACL/MCL ligaments, due to diseased conditions, like:
Adolescent Anterior Knee Pain
Bowed Legs ( Blountâ€™s Disease)
Deep Vein Thrombosis
Osgood Schlatter Disease
Sciatic Nerve Injuries
For chronic pain, stiffness and functional loss of these tissues, conventionally knee replacement and/or surgery was the only recommended option. However, as with most of the surgical procedures, knee surgeries as well exhibit certain risks, like opportunistic infections, rejection by the body, longer recovery periods, cost, etc. Moreover, it may as well affect certain high impact activities; for these reasons, many patients have turned their minds to stem cell therapy as the safest alternative to knee replacement surgeries.
Pathophysiology of Knees
As we all know, the primary tissue section that is been affected in the knee injuries, is the shock absorbing, cushioning material known to be cartilages. So, let us take a little time to explore in great details, what exactly cartilage is?
The main cell type found in the cartilage, which absorb as shock absorbing cushioning material is the chondrocytes. These cells are derived from progenitor cells called chondroblasts, which are trapped in the developing cartilage, between interspaces called as â€śLacunae.â€ť From here only these cells are nourished to produce all the required constituents like collagen, synovial fluid, etc. Unfortunately, these structural boundaries are making them unable to migrate to the areas of damage. This is further compromised by the presence of the cartilaginous matrix, acting as immune barriers, like lymphocytes and immunoglobulines, assisting in the healing process. Moreover, a lack of blood supply is associated with the delayed matrix formation, with the limited ability to recover from the insult.
Many of the knee issues are associated with the malfunctioning of the chondrocytes, forcing a change in 0its composition. This change further prevents production of large water retaining proteins, allowing a cartilage to dehydrate completely. This cracking of cartilage is termed as fissuring, which progressive prevents it from recovery.
It should be noted that in the early stage of the issue, the bone attempts to do all that it can; in fact, the body lays down more bone around the joint to strengthen the region. However, bone can never withstand any drastic insult as dealing with the repetitive load of joint movement and as such it fatigues. The result of this failure is unbearable pain.
Adult stem cells can be recovered from our own body tissues, like adipose tissue/fat, which can be recovered in larger quantities and are allowed to differentiate inside the body. (In Vivo) In fact, adult forms of these stem cells are being stored in all mature organs and are poised to leap into the action to repair damage, which has occurred from day to day wear and tear of the body. However, as we age or have bigger issues as mentioned here with our body may not be able to recruit enough number of these biological adjutants to the desired location, to fully repair the area.
Advancells helps overcoming this problem by extracting stem cells from belly fat, an area with high stem cell numbers, then concentrating these mighty cells in the controlled environment and reinjecting into the damaged area, to allow natural regeneration of lost body parts.
Super concentrated Platelet Rich Plasma & Advanced Platelet Lysate Procedures
We are specialized our treatment protocol with stimulation technique; wherein we trigger your stem cells, with reach concentrate of growth factors, extracted from autologous blood. These laser activated stem cells, when infused into patientâ€™s body, can immediately start signaling. These signals are being identified by the immune cells, which attract stem cells to the targeted areas.
Our advanced technology is more concentrate and a new improved version of traditional platelet rich plasma, with a whooping 99% success rate in all orthopedic conditions.
We understand the science behind stem cell therapy and hence try to offer a very comprehensive treatment protocol, with maximum recovery.
Our procedure can be divided into
Step 1- Qualification For The Treatment
As per these results, the patient will be counseled further for final decision of protocol.
Step 2- Source Extraction
On the basis of consultation and requirement, a source of stem cells will be decided. On a generalized note patient will be prescribed autologous extraction of bodyâ€™s own stem cells; however, in certain conditions, the procedure can be little diverted from its path, for a better outcome.
Sample extraction can be done from the patient, on the specified date and time; with the application of local anesthesia. The entire procedure takes around 7-8 hours; however, in case of certain conditions like patient has to be with us for little longer period of time.
If you are still curious to know more about the procedure, kindly refer our detailed snapshot below:
Step 3- Laboratory Processing
The extracted sample will be dispatched to our regulatory compliant, cGMP authorized laboratory for processing. Advancells processing facility is a state of the art, class 10,000 clean room, equipped with all automated technology. Stem cells will be isolated from the source, processed further and revitalized with patientâ€™s own plasma and laser stimulation for the quick repair and natural recovery.
Stem cells will be concentrated in injectable volumes, with minimum manipulation and will be characterized for their quality, purity and viability. For us, every client is precious and would like to maintain complete transparency between two of us, which is why we are providing third party certificate of quality, along with our Certificate of Analysis.
Step 4- Stem Cell Implantation
The enriched fraction of stem cells will be infused directly into the patientâ€™s body through one of the modes of implantations, mentioned below.
Targeted Delivery: - Cells will be delivered directly at the site of injury; i.e. between the joints in case of knees, using guided imaging technology.
Ten patients mean age â‰Ą 45 years (Sex ratio; 2 male: 3 female) with chronic knee pain unresponsive to conservative treatments and radiologic evidence of degenerative arthritis were treated with autologous bone marrow stem cells by intra-articular injection (Read more...)
Orthopaedics the branch of science, focusing on injuries and diseases of the body's musculoskeletal system; including bones and muscles.
What is joint replacement surgery & how long it last?
Joint replacement surgery is performed to replace damaged joint with a new, artificial joint known
as a Prosthesis. On an average, these joints have a lifespan of 10 years, however it varies depending
upon the usage and person's age.
What is the difference between the sprain or strain?
A strain occurs when the muscle or tendon is stretched or torn. A sprain occurs when a ligament is
stretched or torn.
What is Sciatica?
In our lower back, nerves join to form the Sciatic Nerve; which runs down in the leg and controls the
muscles of the leg. Sciatica is the condition that may cause a radiatic pain, numbness, tingling and/or
muscle weakness in the leg.
What is shoulder impingement?
Impingement syndrome, is a common disorder of the shoulder referring to an improper
alignment of the bone and the tissues in the upper arm. Inflammatory conditions such as arthritis
are closely related to the impingement syndrome.
What is the separated shoulder?
A shoulder separation occurs when the outer end of the collarbone separates from the end of the
shoulder blades because of the torn ligaments. The injury occurs most often from a blow to the
shoulders or stretched hand or arms.
Do men get osteoporosis?
Although osteoporosis is more common in women, atleast one in eight over 50 have the chances of
getting osteoporosis. As with the declined testosterone levels in men can also lead to increased
chances of the bone loss.
How can Osteoporosis be prevented?
Osteoporosis can be prevented by reaching the peak bone mass, during the childhood and teenage
years. Few habits can be incorporated in order to increase bone mass such as enough calcium and
vitamin D uptake by drinking milk and milk products, regular exercise, avoiding milk and milk
products, avoiding smoking and excessive alcohol consumption.
Can stem cell treatment, reverse my damage?
Yes, stem cells are the pristine cells of the body, which can give rise to many different types of cells
upon proper signalling. These cells have been exploited successfully to differentiate into neurogenic,
osteogenic and chondrogenic lineages. They have been isolated from the very own potent sources of
our body known as Bone Marrow and Adipose Tissues. They can be minimally manipulated and
implanted back into the body to promote neuroregeneration, bone reconstruction, reformation of
tendons and cartilages.