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Stem cell therapy for Liver Damage
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Stem Cell Treatment For Liver Damage

Liver is the largest organ inside our body, located in the right side of the belly. It weighs about 3 pounds and is reddish brown in color. The liver mainly helps to digest the food that we ingest inside. The toxins that are produced during the process of this digestion are excreted out as poisons and energy released during this process is stored for further use.

It secreted many digestive juices along with the bile. Its leading job is to filter the blood coming from the digestive tract before passing it to the rest of the body. It secretes various digestive juices along with the bile for the detoxification and metabolism of the food or drug that has been consumed by our body. It also has some involvement for the secretion of proteins that are required for blood clotting.

Since the liver is involved in variety of critical functions in the body, any trauma or disturbances in normal functioning of the liver can give rise to severe liver diseases, which can create havoc. Some of the well known liver diseases, are listed below:

Symptoms

Major Manifestations in patients include the following:

  • Hepatitis
  • Cirrhosis
  • Liver Cancer
  • Liver Failure
  • Ascites
  • Gall stones
  • Hemochromatosis
  • Primary Billiary Cirrosis

Since the liver is involved in variety of critical functions in the body, any trauma or disturbances in normal functioning of the liver can give rise to severe liver diseases, which can create havoc. Some of the well known liver diseases, are listed below:

Liver cirrhosis is the slowly progressive disease in which the healthy liver tissue is affected by some environmental factors such as alcoholism, viral infections, over intake of some medication and is replaced with the scar tissue. The condition may prevent the normal functioning of the liver with the help of blockage that can slow down the processing of nutrients, hormones, drugs and naturally produced toxins from the body. It also involves in slower production of certain hormones and proteins required for the digestion.

Any traumatic condition that may damage the liver can result in liver cirrhosis, this may include

  • Fatty liver associated with the obesity and excessive intake of steroidal medicines
  • Chronic viral infections of the liver, such as Hepatitis B, C
  • A genetic blockage of the bile duct or its complete absence
  • Cystic fibrosis
  • Certain genetic malformations
  • Prolonged exposure to environmental toxins

The symptoms of the patients with liver cirrhosis may vary depending upon the intensity of the illness, however some commonly associated symptoms can be

  • Loss of appetite
  • Lack of energy, which can be debilitating
  • Weight loss or sudden weight gain
  • Bruises
  • Yellowish, itchy skin
  • A brownish or orange tint into the urine
  • Light colored stool
  • Confusion, mood swings
  • Fever

In general, the condition can be diagnosed with the physical examination or blood tests, however liver biopsy can be performed to find out the level of tissue scarring. Although the liver cirrhosis is generally referred as the chronic stage of liver failure and liver transplantation with the matched donor is the only possible alternative for the same so far available.

With the advent of stem cells technology, some positive changes have been observed for the patients who have been suffering from the diseases. Stem cells are the naive cells of the body, which can be differentiated to become any cells if treated in proper condition. This remarkable potential of stem cells has been exploited by the medical science as a possible cure for a variety of debilitating diseases. Researchers have observed positive differentiation of stem cells in hepatic lineages.

Using stem cells for treating liver failure or liver cirrhosis is still at a very nascent stage, however patients have expressed positive signs after treatment. The stem cells can be harvested in limits number from potent sources such as Bone Marrow or Adipose Tissue. These stem cells can be injected back into the body at the targeted place. These stem cells then can be differentiated into liver cells with the help of certain growth factors and immunological factors such as cytokines. The stem cell injection can also be coupled with stem cells stimulation therapy, wherein resident stem cells are stimulated to multiply and differentiate inside the body as a booster effect.

The major advantage of these stem cells is that since they have come from the patient own body sources, there are no chances of their rejection or other infections.

Hepatitis is an inflammation of the liver. Hepatitis C is a viral infection generally is spread through the contact of infectious blood. This may be because of unprotected sex or transfusion of infected blood or from the mother to the baby during childbirth. Since the virus remains in the window period for a too long, most of the times the person will not be known that he is affected by HCV for years. Many times the symptoms are also relevant to the flu symptoms that may lead to easy misunderstanding that the person may be having a normal flu. The common symptoms that have been reported so far are

  • Chills
  • High fever
  • Headaches or body aches
  • Yellowing of skin or eyes
  • Dark colored urine
  • Pale Bowel Movements

The infection of hepatitis is lifetime leading to the scarring of the liver or liver cancer in later stages of the disease. Usually, a normal blood test is required to be performed to identify whether the person has been infected with HCV. If the blood test comes positive, then a liver biopsy and liver function test are prescribed to understand the intensity of the disease.

Some sort of medicine can help to get some relief from symptoms, however long term use of these medicines are not advisable as there is a risk of other opportunistic infections or side effects. So far liver transplantation from a matched donor is the only possible alternative to treat the disease.

Although with the advent of the stem cell technology, it is now possible to look at HCV with different perceptions. Stem cells are the youngest cells of the body which are capable of differentiating into many new cells of the body. These stem cells are present in a dormant state in the human organs throughout the life of an individual. Liver stem cells are also present in the liver, which are utilized in cases of diseased condition for the production of tissue specific cells which are damaged. However, the demand is very intense in chronic condition and hence an external supply of stem cells is required to compensate.

Here at Advancells, the treatment has been offered to patients who have been suffering from chronic HCV and desperately looking for the potential alternative treatment option to produce a cure, regenerate liver and regain the energy before being stuck down with the Hepatitis C. The human bone marrow is an abundant source of resident stem cells, which can be effectively utilized for blood related disorders. They serve as a sort of cellular repair system, continuously subdividing, giving rise to one stem cell and one tissue specific cell may be liver cell, that could potentially repair liver; that has been scarred or damaged by chronic condition.

Along with the stem cells injection, a stimulation therapy can also be suggested in some of the cases as per the requirement, wherein the body's natural ability to create new stem cells, their multiplication and differentiation into required tissue specific cells is boosted.

Hepatitis is an inflammation of the liver. Hepatitis B is a viral infection generally caused due to the direct contact with the infected person or indirect contact with the body fluids such as infected blood, semen or other body fluids. It is also evident that a baby born from the infected mother also can be hepatitis B positive as the virus can transfer placenta.

Some of the commonly associated symptoms of HBV can be

  • Chills
  • High fever
  • Headaches or body aches
  • Yellowing of skin or eyes
  • Dark colored urine
  • Pale Bowel Movements

In general, Hepatitis B can be prevented with the help of the vaccine. All babies and adults can always opt for the vaccines, which is given in three shots. Although the prevention is easier than its cure. Once the person is infected with HBV, it does not get better and can last for a lifetime. Chronic HBV can lead to scarring of the liver, which in later stage may even cause complete liver failure or liver cancer. This particular condition has no known cure. However, certain medications are available to help the patient to get rid of the pain he is suffering from. However, their long term use can be harmful and can be the major reason for the entry of other opportunistic infections.

With the help of the current advancements in the medical science, stem cells technology can be a potential alternative to treat deadly diseases such as Hepatitis. Stem cells are the youngest cells of the body, which are capable of differentiating into many different cells with the help of proper secretion of growth factors and other cytokines. These remarkably potent cells are thus exploited by the healthcare sector to treat a variety of chronic illnesses, for which known domain of treatment is not present.

Here at Advancells, the treatment has been offered to patients who have been suffering from chronic HBV and desperately looking for the potential alternative treatment option to produce a cure, regenerate liver and regain the energy before being stuck down with the Hepatitis B. The human bone marrow is an abundant source of resident stem cells, which can be effectively utilized for blood related disorders. They serve as a sort of cellular repair system, continuously subdividing, giving rise to one stem cell and one tissue specific cell may be liver cell, that could potentially repair liver; that has been scarred or damaged by chronic hepatitis B.

Along with the stem cells injection, a stimulation therapy can also be suggested in some of the cases as per the requirement, wherein the body's natural ability to create new stem cells, their multiplication and differentiation into required tissue specific cells is boosted.

List of diseases treated

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Stem Cell Treatment

Stem Cell Treatment For Liver Damage: Advancells Protocol

With the help of tremendous regeneration power of stem cells, it is possible to stimulate liver function and reduce scarring. At Advancells, we are exploiting the most potent stem cells isolated from patients own bone marrow or adipose tissue or may be both depending upon the assessment. Our top priority is to provide very comprehensive, individualized treatment pattern which is best suited for the patients undergoing treatment. In about 2/3rd of the patients we observe long lasting improvements in liver function, causing less tiredness, increased secretion of liver enzymes.

Primary objective of our proposed treatment plan would be to stop further degeneration of Liver and to improve liver function.

Step 1- Qualification For The Treatment

A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pretreatment assessments can be suggested depending upon the patient's medical and family background:

  • Infectious Disease testing
  • Liver Function Tests
  • Urine Analysis
  • Physical Examination
  • Liver Biopsy
  • MRI
  • CT Scan
  • Ultra Sound

As per these results, the patient will be counseled further for final decision of protocol.

Step 2- Source Extraction

With the With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolated from Bone Marrow or Adipose Tissue, as these are the most potent autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cells stimulation therapy for some, depending upon the severity and requirement.

The specified amount of sample will be extracted from the patient's own body on the intimated date and time, with the application of local anaesthesia. The entire procedure takes around 7-8 hrs, however, in case of extraction from both the sources the patient has to be with us for a little longer time.

If you are curious to know more about the procedure, kindly refer our detailed snapshot below :

Stem cell therapy Procedure for Liver Damage

Step 3- Laboratory Processing

The extracted sample, will be sent to the government approved cGMP laboratory for processing. The sample processing will be done in a state of the art class 10,000 clean room in compliance with the ISO and GMP standards.

The sample will undergo minimum manipulation in our complete automated Sepax technology to be enriched with the pure population of stem cells culture. The isolated stem cells will be characterized for quality, purity and viability.

The client will be given a third party certificate from Internationally Accredited Lab for the quality purpose.

Step 4- Stem Cell Implantation

Once stem cells are enriched and ready to be injected back into the body, we have worked on different modes of implanting them. However, depending upon the patient's physiological and mental well being, one of the following will be finalized by our experts.

Follow up Treatment

In a post treatment care, the patient will be asked to visit the doctors after a specific period of time, by which he will be again undergoing some blood tests & ultrasound to analyze his improvement. Additionally, the patient will be regularly counselled to understand his physical and mental well being.

 

Result

Liver Damage Stem Cell Treatment Results

Majority of the patients treated with us have shown marked improvement reduction in inflammation of the liver and improved liver function test results.

Patient's Stories

D K, Liver Cirrhosis Treatment

"Mr. D K had been a heavy drinker for the past many years resulting in his liver getting early signs of degeneration. His doctors had told him that he is looking at a possibility of developing Cirrhosis soon and could ultimately end up needing a liver transplant in a few years time. Mr. D K decided that he wants to try regeneration of liver through stem cell therapy and contacted Advancells for help. ...."

Fibroscan results of patient Shailender Singh pre and post Stem Cell Therapy clearly shows the fibrosis of the liver going down. The scan has been co related clinically and patient has reported reduction of severity of symptoms and reversal of the disease.

Pre Stem Cell Therapy

Pre Stem Cell Therapy

Post Stem Cell Therapy

Post Stem Cell Therapy

Watch Video of our patient to know how he has been benefited from Stem Cell Treatment.

Watch Video of our patient to know how he has been benefited from Stem Cell Treatment.

 

Video

Shailendra Singh, Liver disease patient Video, 42 Years Old
liver disease treatment
More Video

FAQ's

Frequently Asked Questions

  • What is fatty liver?
  • Fatty liver is excessive deposition of fat droplets in the cytoplasm of liver cells, which may progressively be accompanied by fibrosis. It is the common problem, troubling 90-100% of heavy drinkers. This is so far known to be the major cause linked with the condition, which if unattended for a longer period of time may give rise to palpably enlarged liver with death.
  • What quantity of alcohol should I limit safely to avoid liver damage?
  • Any amount of alcohol can produce damage to the liver, however the general thumb rule for an otherwise healthy person can be 3-4 drinks a day for men and 1-2 drinks per day for women, since men metabolize and are able to clear alcohol very efficiently than women due to body size, body fat and certain enzymes. However, if an individual has an underlying liver conditions such as hepatitis B or C or liver damage, the liver can be very sensitive to alcohol, and in that case the only safe dose of alcohol is zero.
  • What is the liver cirrhosis?
  • The liver cirrhosis is the liver disease, characterized by widespread destruction and degeneration of liver tissue often marked with an increase in fibrotic connective tissue. The liver has always been in a tendency to regenerate on its own, however, due to regular degeneration and regeneration process, it forms structural nodules leading to permanent alteration of its structure and function, due to scarring and increased formation of the connective tissue. If unattended for a longer period of time, its continuous necrosis and fibrosis may cause progressive destruction with end stage liver disease.
  • Does our liver give any kind of warning signals?
  • Our liver is normally a silent organ, suffering silently for a longer period of time, however, if you suddenly suffer from stomach pain or stomach upset, you need to visit the doctor. Apart from that, sudden exhaustion, bloated stomach, morning sickness and glassy eyes with red and blue blood vessels under the eyes are the alarming signals when you need to visit the doctor.
  • Can the oral medications or contraceptive pills cause damage to the liver?
  • Yes, medication which contains steroids and their long term use can be harmful to the liver. Similarly, birth control pills with high level of oestrogen can also be dangerous and hence should be avoided.
  • Can liver damage be reversed?
  • Yes, to some extent, liver is a regenerative organ, liver cells regenerate minor injuries on its own, however, their potency is limited to cope up for the major damage and hence it is always advisable to visit the doctor if you notice the warning signals of the liver damage.
  • Is the adult autologous stem cells therapy an only alternative?
  • At present stem cell treatment can be offered from a variety of sources such as umbilical cord blood, tissue mesenchymal cells, autologous sources etc to reverse the damage associated with the disorder, however the most safe amongst them can be an autologous way as the body’s own cells have been used. There are least chances of immune rejection and other infection. Additionally, these sources are readily available within you and you need not have to wait for the right match. This in turn saves lot of time and complications.
  • Can I expect my liver back to normal immediately after stem cells treatment?
  • Since the stem cells treatment is progressing rapidly, every day it comes up with the new discovery however, currently patients have been reported to get improved metabolism, improved stamina, minor complaints have been resolved such as pain, constipation, vomiting. Additionally no cases have been reported to be damaged further after stem cells transplantation. Thus rather than wasting time, money and health you can always go for stem cells transplantation, but you can’t expect your liver to be working naturally.
  • Where can I get more information about Disease?
  • Please go through, our treatment brochures for other Liver Diseases related information.

 

What can you expect?

Many of the patients after stem cell treatment reported to be exhibiting:

  • No reported case of ill effect from the treatment
  • Considerably low viral load within few months of the treatment
  • Reduced liver inflammation & improved function as evident from the liver function tests
  • Increased stamina, energy and willpower observed.
  • Complete stoppage of progression of the disease