Stem Cells To Treat Multiple Sclerosis

Stem Cell Therapy for Multiple Sclerosis

A complex degenerative disorder of the central nervous system is characterized by long-term progressive loss of axons. It is identified to be an autoimmune disease, attacking the central nervous system and damaging nerve fibers; further making it very hard for the brain to “talk” with the rest of the body. Several medications, currently offered to manage symptoms of multiple sclerosis are reported to cause serious side effects and may stop working over a period of time. With the option of regenerative medicine, 69-70% of people with MS can manage gracefully its symptoms as well as delay progression and relapse.

Stem Cell Treatment for MS: Advancells Protocol

The current success in managing MS depends largely on the regulatory action of the adaptive immune system; which is identified to be a key driver of disease pathogenesis. Mesenchymal stem cells, when administered along with their own exosomes can work to prevent acuter inflammatory insults by limiting the infiltration of activated T cells, B cells, and macrophages. Due to the same, these cells cannot further contribute to the demyelination leading to progressive loss of axons. Although, more in-depth clinical understanding and a clear rationale of use are still needed; currently, stem cells and exosomes are identified to be the best available treatment option for a quality life.

Stem Cell Therapy for Multiple Sclerosis: Advancells Protocol

Treatment Qualification

Source Extraction

Processing of stem cells

Re-infusion

Studies have discovered that mesenchymal stem cells and their exosomes can significantly increase myelin content, oligodendrocyte precursor cells, and neural stem cell levels. They are also identified to reduce oxidative stress in hippocampal slice culture, leading to delayed progressive degeneration. Based on these observations, we propose the adjunct use of exosomes along with mesenchymal stem cells to stimulate remyelination for patients with different types of multiple sclerosis, like
Dysesthesia
Dysesthesia
Wadding Gait
Extreme Fatigue
Large Calf Muscles
Loss of balance
Numbness, tingling sensation
Numbness, tingling sensation
Visual Problem
Visual Problem
Vertigo/Dizziness
Vertigo/Dizziness
Trouble seeing
Trouble seeing
Increased sensitivity to heat
Increased sensitivity to heat
Numbness in the feet
Numbness in the feet
Depression
Depression
Difficulty in clear thinking
Difficulty in clear thinking
Frequent urination
Frequent urination
Muscle spasm
Muscle spasm
Extreme pain like headache, pain in legs and feet
Extreme pain like headache, pain in legs and feet
Muscular weakness
Muscular weakness
Trouble maintaining balance
Trouble maintaining balance
Visual problem
Visual problem
Paralysis
Paralysis
Extreme fatigue
Extreme fatigue
Numbness, tingling sensation
Numbness, tingling sensation
Difficulty walking and coordination
Difficulty walking and coordination
Problem with cognition
Problem with cognition
Bowel and bladder issues
Bowel and bladder issues
Difficulty in walking and coordination
Difficulty in walking and coordination
Extreme tiredness
Extreme tiredness
Muscle spasm
Muscle spasm
Visual loss
Visual loss
Memory trouble
Memory trouble
Problem focusing
Problem focusing
Vertigo
Vertigo
Experts are still trying to understand the exact mechanism to know the underlying cause of multiple sclerosis, although a lot is understood so far, thanks to the intense research going on worldwide. Factors that may trigger the sudden onset of MS are:
Causes-of-muscular-dystrophies

CAUSES OF
MUSCULAR DYSTROPHIES
  • Exposure to certain viruses and bacteria like Epstein-Barr Virus can trigger MS later in life.
  • Environmental susceptibility also plays a very important role in managing epigenetic changes.
  • Lack of sufficient vitamin D is identified to be a risk factor for multiple sclerosis.
  • It is an autoimmune disorder and hence, the abnormal immune response can cause inflammation and damage to the central nervous system.
  • Certain studies have confirmed that obesity increased the risk of later developing MS.
  • Many viruses and bacteria including measles, canine distemper.
The stem cell therapy administered in combination with exosomes can be an effective alternative to regularize immune inflammation in the body, a primary cause of multiple sclerosis. Along with immunomodulatory therapies to regulate underlying immune disorders specifically directed toward reducing the episodes of relapse; rehabilitative support is also identified to be necessary to delay the progressive degeneration of brain mass. Accordingly, we have compiled a series of rehabilitation programs to get symptomatic benefits for Multiple Sclerosis.
Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy Recently, multiple studies have confirmed the advantages of ozone therapy or hyperbaric oxygen therapy. With more supply of oxygen to the brain, these therapies reduce brain damage and functional loss. Also, during treatment due to increased atmospheric pressure, the brain goes into a hypoxic state for some time, redirecting stem cells toward the brain at a faster rate. The therapy has been very effective if taken immediately post-infusion.
Hydrotherapies
HydrotherapiesAs per our database, a series of water-based exercises can significantly reduce pain intensity in people with Multiple Sclerosis. Some studies have also noted benefits in managing depression in people suffering from multiple sclerosis. Some researchers are also using Ai Chi, a water-based version with benefits like stress management, posture control, body awareness, strength as well as balance.
Physiotherapy
PhysiotherapyGeneral physiotherapy sessions are helpful in managing certain symptoms of MS, through improved fitness, stamina, strength, and flexibility. In addition to the same, physiotherapy has also proven to be beneficial for regulating mood swings, raising self-esteem, increasing muscle size, and preventing joint contracture.
Cooling/Lowering of Body Temperature
Cooling/Lowering of Body Temperature Transient cooling of body temperature while using suitable cold packs or taking cold baths is suggested for patients with multiple sclerosis. This may improve postural stability, muscle strength of the legs, fatigue, and gait. Studies have also suggested the use of cooling garments to increase functional attributes and stamina.
Drug Treatment
Drug TreatmentDepending upon the stage of development of degeneration, our experts can suggest specific drugs like corticosteroids, baclofen, etc. can be offered as multimodal treatment like reducing neurogenic bladder dysfunction.
Occupational Therapy
Occupational TherapyOccupational therapy can be proposed for tonus regulation, reduction of muscular fixation, training of sensory skills, as well as coordination of movements. Our data suggest that there can be a significant reduction of tremor intention after the short-term application of local ice.

Various studies have confirmed that stem cell therapy has proposed promising improvement, thus attracting the attention of researchers as an alternative treatment for people with MS. Also, it should be noted that there is no complete cure for multiple sclerosis. Even conventional therapeutics are offering steroids in the form of capsules, which can delay the progression, contrary to which an alternative medicine can reduce progressive damage of brain cells, improve functional attributes and promote the regeneration of new cells. During clinical analysis, it was observed that

Worldwide Clinical Studies using Stem Cells obtained from different sources

60% people have reported increased survival functions on an average with 87.76 months

  • Multiple Sclerosis

    With the advent of anti-inflammatory properties of stem cells, the science of regenerative medicine has opened new avenues for treating auto-immune disorders like Multiple Sclerosis. Researchers are supporting the idea of delaying the disease progression and repairing the damage caused due to loss of neuronal contact and cellular communication, on the basis of large data gathered from different pre-clinical as well as clinical investigations. Stem cells, isolated from different sources of the human body and coaxed in the laboratory setting to reduce autoimmune-associated inflammation, will soon be considered as the mainstream treatment for fatal, progressive auto-immune disorders like Multiple Sclerosis. Still, a lot needs to be explored on configuring effective pathways for their communication to standardize their therapeutic outcome instead of relying on the steroidal medications, which can trigger damage to other vital organs of the body. Stem Cell Therapy for Multiple Sclerosis can be considered as a safe and viable option, effective in stopping the progression and increasing overall life expectancy.

MULTIPLE SCLEROSIS
TYPES OF MULTIPLE SCLEROSIS

Dysesthesia
Dysesthesia

Extreme Fatigue
Extreme Fatigue

Loss of balance
Loss of balance

Numbness, tingling sensation
Numbness, tingling sensation

Visual Problem
Visual Problem

Vertigo/Dizziness
Vertigo/Dizziness


Trouble seeing
Trouble seeing

Increased sensitivity to heat
Increased sensitivity to heat

Numbness in the feet
Numbness in the feet

Depression
Depression

Frequent urination
Frequent urination

Difficulty in clear thinking
Difficulty in clear thinking


Muscle spasm
Muscle spasm

Extreme pain like headache pain in legs and feet
Extreme pain like headache, pain in legs and feet

Muscular weakness
Muscular weakness

Visual problem
Visual problem

Paralysis
Paralysis

Trouble maintaining balance
Trouble maintaining balance


Extreme fatigue
Extreme fatigue

Numbness, tingling sensation
Numbness, tingling sensation

Difficulty walking and coordination
Difficulty walking and coordination

Problem with cognition
Problem with cognition

Difficulty in walking and coordination
Difficulty in walking and coordination

Bowel and bladder issues
Bowel and bladder issues


Extreme tiredness
Extreme tiredness

Muscle spasm
Muscle spasm

Visual loss
Visual loss

Memory trouble
Memory trouble

Problem focusing
Problem focusing

Vertigo
Vertigo

CAUSES OF MULTIPLE SCLEROSIS
Experts are still trying to understand the exact mechanism to know the underlying cause of multiple sclerosis, although a lot is understood so far, thanks to the intense research going on worldwide. Factors that may trigger the sudden onset of MS are:

CAUSES OF
AUTISM
  • Exposure to certain viruses and bacteria like Epstein-Barr Virus can trigger MS later in life.
  • Environmental susceptibility also plays a very important role in managing epigenetic changes.
  • Lack of sufficient vitamin D is identified to be a risk factor for multiple sclerosis
  • It is an autoimmune disorder and hence, the abnormal immune response can cause inflammation and damage to the central nervous system.
  • Certain studies have confirmed that obesity increased the risk of later developing MS.
  • Many viruses and bacteria including measles, canine distemper
SUPPORTIVE TREATMENTS

The stem cell therapy administered in combination with exosomes can be an effective alternative to regularize immune inflammation in the body, a primary cause of multiple sclerosis. Along with immunomodulatory therapies to regulate underlying immune disorders specifically directed toward reducing the episodes of relapse; rehabilitative support is also identified to be necessary to delay the progressive degeneration of brain mass. Accordingly, we have compiled a series of rehabilitation programs to get symptomatic benefits for Multiple Sclerosis.

Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy

Hydrotherapies
Hydrotherapies

Physiotherapy
Physiotherapy

Cooling/Lowering of Body Temperature
Cooling/Lowering of Body Temperature

Drug Treatment
Drug Treatment

Occupational Therapy
Occupational Therapy

OUTCOMES

Various studies have confirmed that stem cell therapy has proposed promising improvement, thus attracting the attention of researchers as an alternative treatment for people with MS. Also, it should be noted that there is no complete cure for multiple sclerosis. Even conventional therapeutics are offering steroids in the form of capsules, which can delay the progression, contrary to which an alternative medicine can reduce progressive damage of brain cells, improve functional attributes and promote the regeneration of new cells. During clinical analysis, it was observed that

Worldwide Clinical Studies using Stem Cells obtained from different sources

Improvement in clinical signs and symptoms
TESTIMONIAL

With the advent of anti-inflammatory properties of stem cells, the science of regenerative medicine has opened new avenues for treating auto-immune disorders like Multiple Sclerosis. Researchers are supporting the idea of delaying the disease progression and repairing the damage caused due to loss of neuronal contact and cellular communication, on the basis of large data gathered from different pre-clinical as well as clinical investigations. Stem cells, isolated from different sources of the human body and coaxed in the laboratory setting to reduce autoimmune-associated inflammation, will soon be considered as the mainstream treatment for fatal, progressive auto-immune disorders like Multiple Sclerosis. Still, a lot needs to be explored on configuring effective pathways for their communication to standardize their therapeutic outcome instead of relying on the steroidal medications, which can trigger damage to other vital organs of the body. Stem Cell Therapy for Multiple Sclerosis can be considered as a safe and viable option, effective in stopping the progression and increasing overall life expectancy.

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Several studies are going on currently to assess the safety, efficacy, and feasibility of mesenchymal stem cells obtained from various sources like Umbilical Cord, Bone Marrow, and adipose Tissue. However, out of many types of MSCs enrolled for the study, umbilical cord-derived MSCs are proposed to be the best option for treating Multiple sclerosis, due to several obvious reasons

The cells are obtained from a very naïve source, the umbilical cord, and hence have faster self- renewal capacity as compared to other MSCs. These MSCs are pluripotent in nature as against the multipotent nature of MSCs obtained from other adult sources like Bone Marrow and Adipose Tissue. With a considerably higher dose e 1–2 × 106 cells/kg at 3-month intervals for 7 times, due to the higher expansion capacity of these cells, is quite cost-effective without much concern about safety and rejection. Download Brochure

FAQs

Advancells is a strong advocate of greater transparency in medical procedures in general and Stem Cells Procedures in particular. We do not have any medical doctors on our payroll and we do not give any medical opinion or conduct medical procedures at our premises. We are a CGMP compliant cell manufacturing facility and provide each client a Third Party Certificate (from an internationally accredited lab) for the cell count and viability of our cells. View sample Certificate
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