How and where is my therapy done?
You have taken the right decision of getting treatment done at Advancells and so you will be intimated about the time and date, on which you have to meet our representative. Our representative will take you to the specialist at the hospital for a detailed consultation after which you might undergo radiology and/or pathology tests if required. Once the test results are back, the specialist will discuss your treatment modalities in detail. You are encouraged to ask as many questions as you want to; feel completely confident not just about the treatment but also about the doctor and the hospital. All the treatments will be done under the medical surveillance of the most outstanding healthcare specialists such as neurologists, neurosurgeons, cardiologists, anesthetists, orthopedic surgeon, radiologists and pediatricians. The hospitals are of top most standards and a dedicated team of highly trained physicians, patient advisors and nurses looks after the patients. In addition, we provide other facilities for our Outstation patients like travel assistance, hotel booking, transportation, visa assistance etc.
- 18 years and older; If under 18, parental approval is needed
- Patients without chronic condition
- Patient providing written consent to receive treatment
- Haemoglobin less than or equal to 10
- Patients with congenital blood disorders
- Refusal to provide signed informed consent
- Patient had medical surgery within six weeks prior to treatment initialisation
- Pregnant or breast feeding women
- Severe cachexia and malnourishment
- Patients with compromised immunity
- Positive serology for other infectious diseases.
The entire medical procedure at Advancells consists of 4 steps:
1. Source extraction
2. Isolation, analysis and concentration of the stem cells in the laboratory.
3. Stem cell implantation
4. Post treatment care
Stem cell therapy is performed in agreement with the principles of “Good Manufacturing Practice” along with the most advanced technologies and the best medical standards that are available. The risks associated with the adult stem cell therapy are almost negligible. The therapy includes the use of patient’s own cells so the risk of rejection simply does not exist, which might be possible in case if a donor is used.
Depending upon the assessment the source of stem cells will be decided. It can either be bone marrow or adipose tissue. In some specific cases, we can provide stem cells obtained from both the sources but the decision will solely be taken by the treating doctor.
One of our senior Neurosurgeon/Orthopaedic surgeon will extract the bone marrow from the iliac crest (Hip Joint). Normally the procedure takes around 30-45 minutes. Local anaesthesia is first administered on the area of the skin that is to be punctured. A bone marrow extraction needle is then used to extract about 100-120 ml of bone marrow. Option of general anaesthesia is available for patients who need it. Once the extraction is done, the sample will be immediately transferred to our clean room facility for processing.
More detailed information on the bone marrow collection procedure is available in the Bone Marrow Informed Consent document (PDF file).
Isolation of stem cells from Bone Marrow
In a clean room, stem cells will be separated from other unwanted mature blood cells and plasma. The processing of samples will be done as per cGMP standards under sterile conditions. Utmost care will be taken to make sure that stem cells do not get contaminated by any kind of infections. Post processing all samples will be tested for quality and quantity of stem cells.
One of our operating surgeon/cosmetic surgeon will extract an adipose tissue from an area of the body, which is generally pre umbilical area;where sufficient amount of fat is available.Once the location is confirmed a patient will be asked to lie in a supine position. He will be given a local anaesthesia. A 60 CC Cannula is inserted under subcutaneous layer and approximately 100 CC adipose tissue is collected. An option of general anaesthesia is also available for patients who need it. Once the aspiration is complete, the sample will be immediately transferred to the clean room for further processing.
More detailed information on the Adipose Tissue collection procedure is available in the Adipose Tissue Informed Consent document (PDF file).
Isolation of stem cells from Fat
Fat is an abundant source of progenitor/stem cells; which will be separated from other mature cells such macrophages, adipocytes etc in our clean room facility. The processing of sample is done as per approved cGMP standards under sterile conditions. Utmost care is taken to make sure that stem cells do not get contaminated by any kind of infections. Post processing all samples will be tested for quantity as well as quality.
We provide each client a Third Party Certificate (from an internationally accredited lab) for the cell count and viability of the cells that we process from the autologus cell source of the patient.
Stem cell implantation
Stem cells can be implanted in following major ways. They are:
Intrathecal Administration (Lumbar Puncture)
Intra-arterial Administration via catheter
Retrobulbar Infusion of cells
Liberation Angioplasty for Multiple Sclerosis CCSVI
Tissue Reconstruction through Biodegradable Scaffolds
Patients can leave the hospital after few hours of stem cell transplantation although in certain cases especially when cells are transplanted Intra-arterial via catheter or surgeries; a patient is advised to stay for a longer duration.
A 24 hour hotline is available for the patients to clear up any doubts and queries that they may face right after their discharge. Our doctors and patient consultants are always available over phone and emails. A patient can easily be in touch with his or her physician, which in return helps us to study their recovery.
Before undergoing this process; a patient must understand that stem cell therapy is an experimental therapy that may fail to work at certain times.
A patient might be refused treatment or the proposed protocol might change depending on the patient's health condition at the time of procedure.
At Advancells our primary motive is to offer the best technology available; safety of which have been proven across the world.