Stem cell Therapy for Spinal Cord Injury

With a unique approach combining Stem cells and Exosomes

A Hope of cure is now within our reach

Our Novel biologics address Unmet medical demands of many patients worldwide suffering from spinal cord injuries.

We are constantly upgrading our knowledge for the development of better therapeutics.

Stem Cell Treatment for Spinal Cord Injury

A devastating condition of the spinal cord due to sudden injury/trauma/accident, leading to loss of mobility, and sensation in different parts of the body. A spinal cord is packed with nerves relaying important messages from the brain to the rest of the body's organs. Sudden damage may halt the signals of the nerves causing a major functional loss in bladder/bowel movements, breathing, heart rate, sensation, reflexes, metabolism, and muscular movements. Conventionally, surgery and rehabilitative support were the only options to manage SCIs; however, recent studies are suggesting a holistic approach using neuroprotection, surgeries by repairing and regeneration, cell-based therapies, and retaining central nervous system circuits..

Stem Cell Therapy for Spinal Cord Injury: Advancells Protocol

Due to the ability of stem cells to differentiate into any cell type, their potential use in various cell- based therapeutic strategies makes more sense. The appropriate combination of surgeries, cell- based therapies, and retaining network-circuits long-term treatments could be achieved with various objectives like forming neurons and glial cells, functional recovery, and pain management. Exosomes offered along with mesenchymal stem cells are responsible for immune regulation post-stem cell therapy. This offers appropriate protection to the newly formed neurons, by serving as the first line of defense against injury-induced tissue loss, further contributing to the improved neurological outcome.

Procedure of Treatment of Spinal Cord Injury through Stem Cells Therapy

Treatment Qualification

Source Extraction

Processing of stem cells

Re-infusion

Depending upon the kind of injuries, like accidents, falls, gunshot wounds, sports injuries as well as surgical complications; different parts of the spinal cord can be affected. Each section of the spinal cord can impact different sections of the nerves with different functions. It is important to learn about different levels of spinal cord injuries and possible treatment outcomes.
Paralysis in hands, arms, trunk as well as neck
Impaired or reduced ability to speak
Inability to drive a car independently
Little or no voluntary control of bladder movement
Need assistance with more difficult tasks
Unable to grasp and release objects
Significant weakness of legs
Significant loss of sensation in lower limbs
Loss of feeling in genitals as well as rectal regions
No control of urine or stool
Constant fever and lower back pain
A frequent fall
Inability to bend the feet in a particular direction
Loss of flexibility in legs and feet
Numbness and weakness in the legs
Ability to ambulate using braces and other walking devices
Paraplegia with functional independence
Lack of bowel/bladder control
Constant pain in the lower back region
Complete lack of bowel/bladder control
Leg pain radiating down the back of the legs
Sensory issues in the groin and buttock areas
Numbness and weakness in the legs
Changes in the sexual functions
Muscle weakness in fingers and hands
Muscle twitching, fasciculation, twitching
Decreased arm strength
Frequent episodes of spine stiffness
Intermittent muscle spasm
Drooling
Primarily, all spinal cord injuries are a result of damage to the vertebrae, ligaments, and spinal disc either due to sudden trauma or due to chronic illnesses. Some of the common causes of spinal cord injuries are:

CAUSES OF
SPINAL CORD INJURIES
  • Motor vehicle accidents are the leading cause of spinal cord injuries, accounting for almost 50% per year.
  • After a certain age, specifically 65 and above, spinal cord injuries are often due to frequent falls.
  • About 10-12% of spinal cord injuries are due to violent encounters, usually due to gunshot wounds during the war or knife wounds during fights.
  • Certain chronic illnesses like cancer, arthritis, osteoporosis, and chronic inflammation can also cause damaged spinal cords.
  • Horseback riding for a longer period can cause spinal cord injuries at certain levels.
  • About 12% of spinal cord injuries occur during surgeries.
Relevant studies have suggested further that the treatment of spinal cord injuries should always be multifaceted, considering the social and political context of the injuries. As stated earlier a combinational approach using surgeries, circuit devices for loss of sensation, and cell-based therapies along with exosomes can be helpful for significant improvement and symptomatic management of spinal cord injuries. Accordingly, we have come up with certain supportive treatments offered along with suitable treatment options, to promote neuroprotection, cellular repair as well as regeneration, and reduced inflammation.
Hyperbaric Oxygen Therapy Recently, hyperbaric oxygen therapy is considered a novel method to en route infused stem cells at the site of injury. During HBOT sessions, hypoxia is created in the brain due to increased atmospheric pressure, due to which stem cells get guidance to reach the site of injury. Studies have proposed that HBOT sessions should be given immediately post stem cell therapy sessions.
Hydrotherapies Hydrotherapies is a kind of water exercise suggested post stem cell therapy in spinal cord injury patients to promote posture control, sensation, and awareness in case of loss of bladder and bowel movement. Prior clinical investigations have reported that multiple sessions of hydrotherapies undertaken regularly can have a significant impact on increasing muscle mass, promoting good control over movement, and stress management, and can increase body awareness.
PhysiotherapyAlong with hydrotherapies, regular sessions of physiotherapy have also been proposed by experts for improved fitness, strength, stamina, and flexibility. Physiotherapy can also be helpful in regulating mood swings, boosting confidence, and promoting strength.
Functional Electrical StimulationFunctional electrical stimulation is an advanced technique proposed for the artificial activation of sensory-motor systems through the integration of electrical pulses. This technique is useful in promoting action potential in both afferent as well as efferent pathways of neurons that are responsible for increased functional gain in muscles.
Dry Needling/AcupunctureDry needling is a kind of invasive procedure, wherein with the help of dry needles, muscle myofascial
trigger points are activated to reduce the sense of pain and weakness. With the activation of these tense muscle nodules, there is a considerable reduction in pain as well as spasticity. It is also found to be important for improving gait speed and stability in patients with an incomplete form of injury.
ExoskeletonsThese are the battery-powered robotic devices or chips that are helpful in operating in a manner to ease mobility, maintain posture as well as gait, and promote recovery through repeated movements.

As discussed previously, various studies have confirmed how a combination approach in the case of different types of spinal cord injury is helpful to offer holistic treatment right from posture control, and pain management to increased mobility and functional gain. Accordingly, on the basis of data collected from extensive studies to elucidate the mode of action of stem cells and exosomes infused in patients suffering from spinal cord injury; it can be suggested that

Worldwide Clinical Studies using Stem Cells obtained from different sources

70% people have reported increased survival functions on an average with 87.76 months

Majority of the patients treated at Advancells have shown marked improvement in bladder and bowel control function, improvement in muscle spasm and lesser neurogenic pain. Regenerative Therapy Innovations allow patients to get better control of their life and see improvements in their condition.

Find out how Stem Cell Therapy Is improving the lives of Spinal Cord Injury patients

READ SPINAL CORD INJURIES SUCCESS STORIES

TYPES OF SPINAL CORD INJURIES

Paralysis in hands arms, trunk as well as neck
Paralysis in hands, arms, trunk as well as neck

Impaired or reduced ability to speak
Impaired or reduced ability to speak

Inability to drive a car independently
Inability to drive a car independently

Little or no voluntary control of bladder movement
Little or no voluntary control of bladder movement

Need assistance with more difficult tasks
Need assistance with more difficult tasks

Unable to grasp and release objects
Unable to grasp and release objects


Significant weakness of legs
Significant weakness of legs

Significant loss of sensation in lower limbs
Significant loss of sensation in lower limbs

Loss of feeling in genitals as well as rectal regions
Loss of feeling in genitals as well as rectal regions

Constant fever and lower back pain
Constant fever and lower back pain

A frequent fall
A frequent fall

No control of urine or stool
No control of urine or stool


Inability to bend the feet in a particular direction
Inability to bend the feet in a particular direction

Loss of flexibility in legs and feet
Loss of flexibility in legs and feet

Numbness and weakness in the legs
Numbness and weakness in the legs

Ability to ambulate using braces and other walking devices
Ability to ambulate using braces and other walking devices

Paraplegia with functional independence
Paraplegia with functional independence

Lack of bowel/bladder control
Lack of bowel/bladder control


Changes in the sexual functions
Changes in the sexual functions

Constant pain in the lower back region
Constant pain in the lower back region

Complete lack of bowel/bladder control
Complete lack of bowel/bladder control

Leg pain radiating down the back of the legs
Leg pain radiating down the back of the legs

Sensory issues in the groin and buttock areas
Sensory issues in the groin and buttock areas

Numbness and weakness in the legs
Numbness and weakness in the legs

CAUSES OF SPINAL CORD INJURIES
Primarily, all spinal cord injuries are a result of damage to the vertebrae, ligaments, and spinal disc either due to sudden trauma or due to chronic illnesses. Some of the common causes of spinal cord injuries are:

CAUSES OF
SPINAL CORD INJURIES
  • Motor vehicle accidents are the leading cause of spinal cord injuries, accounting for almost 50% per year.
  • After a certain age, specifically 65 and above, spinal cord injuries are often due to frequent falls.
  • About 10-12% of spinal cord injuries are due to violent encounters, usually due to gunshot wounds during the war or knife wounds during fights.
  • Certain chronic illnesses like cancer, arthritis, osteoporosis, and chronic inflammation can also cause damaged spinal cords.
  • Horseback riding for a longer period can cause spinal cord injuries at certain levels
  • About 12% of spinal cord injuries occur during surgeries.
SUPPORTIVE TREATMENT

Relevant studies have suggested further that the treatment of spinal cord injuries should always be multifaceted, considering the social and political context of the injuries. As stated earlier a combinational approach using surgeries, circuit devices for loss of sensation, and cell-based therapies along with exosomes can be helpful for significant improvement and symptomatic management of spinal cord injuries. Accordingly, we have come up with certain supportive treatments offered along with suitable treatment options, to promote neuroprotection, cellular repair as well as regeneration, and reduced inflammation.

Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy

Hydrotherapies
Hydrotherapies

Physiotherapy
Physiotherapy

Functional Electrical Stimulation
Functional Electrical Stimulation
Dry Needling/Acupuncture
Dry Needling/Acupuncture

Exoskeletons
Exoskeletons

OUTCOME

As discussed previously, various studies have confirmed how a combination approach in the case of different types of spinal cord injury is helpful to offer holistic treatment right from posture control, and pain management to increased mobility and functional gain. Accordingly, on the basis of data collected from extensive studies to elucidate the mode of action of stem cells and exosomes infused in patients suffering from spinal cord injury; it can be suggested that

Worldwide Clinical Studies using Stem Cells obtained from different sources

Improvement in clinical signs and symptoms
TESTIMONIAL

Majority of the patients treated at Advancells have shown marked improvement in bladder and bowel control function, improvement in muscle spasm and lesser neurogenic pain. Regenerative Therapy Innovations allow patients to get better control of their life and see improvements in their condition.

Find out how Stem Cell Therapy Is improving the lives of Spinal Cord Injury patients

Must Read Articles on Spinal Cord Injuries

Autonomic Dysreflexia In Spinal Cord Injury
Autonomic Dysreflexia In Spinal Cord Injury

Living with a Spinal Cord Injury (SCI) has several major side effects, with Autonomic Dysreflexia being one of the most significant (AD). Autonomic dysreflexia is an abnormal reactivity of the involuntary (autonomic) nervous system to stimuli. The good news is that it...

Back Pain and Degenerative Disk Disease- All you Need to Know
Back Pain and Degenerative Disk Disease- All you Need to Know

Back pain due to degenerative disk disease is caused by changes in the spine disks. These disks act as shock absorbers and help in retaining back flexibility. As one gets older with age, these spine disks show signs of wear and tear, affecting the flexibility and...

Locking And Unlocking The Knee Lock
Locking And Unlocking The Knee Lock

Our Knees are the most hardworking joints of our body. Did you know that every time you climb up the stairs, your knees carry up to 5 times your body weight! Sometimes putting a lot of weight on your knees can “freeze” the knees which make them impossible to bend or...

Meta-analysis of Spinal Cord Injury using stem cell therapy

While the majority of the clinical trials on spinal cord injury patients were conducted using mesenchymal stem cells and exosomes; the results are variable from no improvements at all on the ASIA impairment scale to a recovery rate as high as 100%. Certain clinical investigations reported 100% safety and feasibility in the use of mesenchymal stem cells. On average almost 60% of the patients during the acute and sub-acute stages of spinal cord injury reported good improvement in motor functions, while 70% of them show some degree of neurological improvements like increased sitting tolerance, muscle strength, urine control, etc.

Recent Spinal Cord Injuries Patient Case Stories

Majority of the patients treated at Advancells have shown marked improvement in bladder and bowel control function, improvement in muscle spasm and lesser neurogenic pain. Regenerative Therapy Innovations allow patients to get better control of their life and see improvements in their condition.

Find out how Stem Cell Therapy Is improving the lives of Spinal Cord Injury patients

FAQs

 
Advancells is a strong advocate of greater transparency in medical procedures in general and Stem Cells Procedures in particular. As a part of our effort of bringing transparent procedures to our clients, we provide each client a Third Party Certificate (from an internationally accredited lab) for the cell count and viability of the cells that we are able to process from the autologous cell source of the patient. To view the sample copy of the certificate  click here

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