Stem Cell Therapy for Eye Disease



Eye Disorders

The human eye is a complex yet important organ of our body filled with nerves, a lens, liquid and more. This organ gives us the ability to visualize the world in different colors, shapes and dimensions; based on the reflection and refraction principle. In our eye, many major components work simultaneously to capture and transmit the image to the occipital lobe of the brain via optic nerves.

Photoreceptor cells, present in our eyes generate nerve impulses to distinguish colored images with black and white images. A separate information from left and right eye, is sent to the brain via these nerve impulses. This information is then combined by our brain for determining the distance and depth of the image in order to visualize full three dimentional image.

The upward and downward muscular movement of the eye is controlled by superior and inferior rectus muscles, whereas the side movement and staying in level is regulated with the help of medial and lateral rectus muscles. These muscles are in turn controlled over with the help of oculomotor nerves. In order to prevent the frictional damage from these movements, the tears are released by lacrymal glands, which can improve lubrication, remove foreign objects and prevent bacterial infection.

The functional abnormality in any of the above prime components may cause serious eye problems; which if ignored, may progressively lead to vision loss. Thus, there are some eye conditions such as retinopathy or some forms of corneal diseases, which can be very worrying for some of the patients, where as some of the other conditions can be so subtle that they can be routinely cured by an ophthalmologist.

Out of the many listed causes of eye disorders, some of the most complicated one have been treated with the help of stem cells-:

  • Myopia
  • Age Related Macular Degeneration
  • Retinopathy
  • Glaucoma
  • Eye injuries
Stem cell information

The most common name for myopia is nearsightedness. This is the condition depicting problem in refractive mechanism, wherein the nearby objects are clearly visible, but distant objects do not come into proper focus. In general, the condition can be directly associated with the long eye ball or too much of corneal curvature, so that the rays of the light entering into eyes are not correctly focused. The kind of condition is very common in school children and adolescents.

Stem cell information

The macula is the most sensitive part of the retina; located at the back of the eye and is made up of number of light sensitive cells called as photoreceptors. These cells are centrally responsible for crystal clear vision. Due to number of risk factors such as age, family history and smoking these cells begin to die causing progressive degeneration of the macula. When the macula is damaged; the center of your field of view may appear blurry, distorted or dark. The disease is mainly classified into two forms. The Dry Macular Degeneration diagnosed when yellowish spots known as "drunsen" begin to appear on the macula indicating the deterioration of the tissue. The Wet Macular Degeneration is diagnosed when new blood vessels start growing beneath the retina leaking blood and fluid. The wet form of the disease will create dark blind spots in the central vision.

Stem cell information

Retinopathy or retinitis pigmentosa, is the most commonly occurring progressive, degenerative disorder affecting the retina of the eye. It especially affects, the light sensitive cells of the retina known as Rods and Cones. They send the information to the brain regarding every minute detail of your visualisation through the help of optic nerves. RP is characterized by the changes in the pigment due to resultant degeneration of optic nerves. This in turn is associated with thinning of retinal blood vessels as the demand of blood supply is lowered considerably. The predominance of this disorder is related to the genetic defect. It is believed that out of many genes responsible for normal eye functioning, one defective gene can causes this kind of retinal malformation.

Stem cell information

Glaucoma is the chronic eye disease causing progressive destruction of the optic nerves leading to the irreversible blindness if left untreated. The optic nerves carry an image from the retina to the brain for enabling us to visualize the picture. The glaucoma, can be broadly classified as open angle and angle closure based on the anatomy of the eye's anterior chamber, and are further classified as primary and secondary disorder.

  • The Open Angle Glaucoma:- It is the most common form of glaucoma, associated with the blockage of the open eye drainage angle of the eye, leading to the increased eye pressure and thereby damaging the optic nerves.
  • The Angle Closure Glaucoma:- It results when the drainage angle of the eyes narrows and becomes completely blocked. In this situation there is a rapid build up of pressure and can be treated as the medical emergency. The symptoms associated with it includes severe eye pain, blurred vision, headache, rainbow haloes around the light, nausea and vomiting.

Stem cell information

The surface of the eye is made up of thin, transparent dome called as the Cornea. The cornea covers the entire iris and the pupil. The first ray of light that is refracted from the image, strikes the cornea. Since the part is exposed, it is more prone to injuries. There are various reasons of eye injuries such as flying dust, foreign object like metal or sand, a fingernail, an animal claw may cause a damage. A minor scratch or corneal abrasion may lead to corneal ulcers, if unnoticed for a longer period of time.

In addition to the above listed major eye problems; some of the other common problems are as follows:

  • Pterygium:- Benign non cancerous growth
  • Photophobia:-Light sensitivity
  • Scleritis:- Inflammation of the sclera
  • Hyphema:- Collection of blood in the eye
  • Optic Neuritis:- A condition with severe optic nerve inflammation
  • Best Disease:- Best disease, termed vitelliform macular dystrophy, is typically an autosomal dominant disorder (Genetic disorder), which classically presents in childhood with the striking appearance of a yellow or orange yolk like lesion in the macula.

The traditional treatment approach is not successful in reversing the damage to the tissue; but with the great progress in the field of stem cells, it is now possible to bring back the normal vision using easy and natural process.

Stem cells are the naive cells of the body, which are able to differentiate into many types of cells if directed through proper channel. Thus, stem cells isolated from your own tissues such as bone marrow or adipose tissues can be channelized to be corneal cells, photoreceptor cells, optic nerves, muscle cells etc. in the eye to regain its normal function back.

List of diseases treated

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Stem Cell Treatment

Stem Cell Treatment For Eye Disorders: Advancells Protocol

Patients suffering from different eye related ailments are treated by implanting stem cells through retrobulbar or other effective mode to obtain maximum recovery. Advancells is excited by the prodigious prospects of stem cells in treating various diseases, hence we are constantly updating our knowledge and technology to suit unique specifications of each patient. Our principle objective has always been a cessation of disease progress and easing the quality of life to a considerable extent. We are always pledged to deliver safe treatment pattern, by offering "Autologous stem cells from your own Bone Marrow/Adipose Tissue"

Our top priority is to provide very comprehensive, tailor made treatment pattern with the maximum recovery. As a part of our treatment, patient's stem cell are obtained from two sources, Adipose-derived stem cells (ASCs) and Bone marrow-derived stem cells (BMSCs). Sometimes we may use a combination of both, depending upon the assessment.

Step 1- Qualification For The Treatment

A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pretreatment assessments can be suggested depending upon the patient's medical and family background:

Pre-Treatment Assessments

  • Infectious Disease Testing
  • Physical Examination
  • Pressure measurements using tonometry
  • Physical Examination using visual field and visual acuity test
  • Pachymetry
  • Ophthalmoscopy
  • Optic nerve imaging
  • Pupil Dilation
  • Amster Grid Testing

As per these results, the patient will be counseled further for final decision of protocol.

Step 2- Source Extraction

With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolated from Bone Marrow or Adipose Tissue, as these are the most potent autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cell stimulation therapy for some, depending upon the severity and requirement.

The specified amount of samples will be extracted from the patient's own body on the intimated date and time, with the application of local anesthesia. The entire procedure takes around 7-8 hrs, however, in case of extracted from both the sources the patient has to be with us for a little longer time.

If you are curious to know more about the procedure, kindly refer our detailed snapshot below:

stem cell treatment for ALS

Step 3- Laboratory Processing

The extracted sample, will be sent to the government approved cGMP laboratory for processing. The sample processing will be done in a state of the art class 10,000 clean room in compliance with the ISO and GMP standards.

The sample will undergo minimum manipulation in our complete automated Sepax technology to be enriched with the pure population of stem cell culture. The isolated stem cells will be characterized for quality, purity and viability.

The client will be given a third party certificate from Internationally Accredited Lab for the quality purpose.

Step 4- Stem Cell Implantation

Once stem cells are enriched and ready to be injected back into the body, we have worked on different modes of implanting them. However, depending upon the patient's physiological and mental well being, one of the following will be finalized by our experts.

Follow up Treatment

Post treatment, the patient will be asked to visit the doctors for reclamation therapies such as Physiotherapy, patients counselling etc. for accelerated recovery.



Eye Disorders Stem Cell Treatment Results

Many of the patients, who have undergone treatment with us have reported significant improvement in their eye sight as well as eye movement. Their recovery have been very quick after treatment. Read More

Patient's Stories

Nish S 29 years, Macular Degeneration

"...Within a week my vision improved from 6/60 to 6/24..."

Allen Purdy, 57 years, Macular Degeneration

"...Again Thank You Vipul Jain for all you have done!..."

Willie Joswig, 81 years, Wet Macular Degeneration

" vision has significantly improved".

Nancy Rice, 75 years old, Dry Macular Degeneration

"...with stem cell implants the disease does not seem to progress! And that is so with me.".

"...I have observed marked improvement in my eye sight within 14 days of my stem cell treatment..."

William B., 78 years, Dry Macular Degeneration

"...My eyesight has improved from 20/400 to 20/150 in my left eye and from 20/80 to 20/70 in my right, as measured by my ophthalmologist in Seattle...."

*Name changed as per patient's request.


Nish S, Macular degeneration Treatment Video
Nish S, Macular degeneration Treatment Video
Allen Purdy, Macular Degeneration Treatment Video
Allen Purdy, Macular Degeneration Treatment Video
More Video


Frequently Asked Questions

  • Do I need to routinely examine my eyes?
  • Yes, it is always advisable to check your eyes on a regular basis. Young adults between the age group 20-39 should have their eye check ups after every 3-5 years. Whereas adults between the age group 40-64 should have their eye check ups after every 2-4 years. In case of senior citizens above 65 years of age, ophthalmic visit should be once every year. Irrespective of age groups, some people grouped under the category of high risk adults should also visit ophthalmologist once a year such as people with diabetes, strong family history of glaucoma, people with AIDS etc.
  • Will working at a computer screen or sitting close to TV screen damage my eyes?
  • No, there is not yet any scientific evidence that these instruments emit rays that can be harmful to the eyes, however long working hours can be tiresome and hence it is often helpful to take periodic breaks, looking off in the distance etc.
  • Sometimes I do notice dark patchy spots or floaters especially on the white surface, is this the reason for me to worry?
  • These are the common eye problems which are indications of retinal or corneal malfunctioning. It is always advisable to visit the doctors as early as possible.
  • Why have gradually found it harder to read without glasses?
  • The ability to focus the near objects decreases with age and is referred to as presbyopia. The condition is known as the natural aging of the optic lens. The condition is often irreversible with conventional treatments, however, stem cells can to some extent reverse the damage naturally, with complete stoppage of further progression.
  • Will my child likely to inherit some eye problems?
  • Yes, some of the eye disorders such as glaucoma, photophobia etc. are observed to be directly linked up with a genetic abnormality which can either be hereditary or mutational. However, some of the common eye problems such as burns, corneal damage, etc. are linked with environmental damage.
  • Can eyes be transplanted?
  • No, there are no evidences currently to transplant the whole eyes, however part of the eye can be replaced if a suitable donor is found.
  • Can stem cell treatment, reverse my damage?
  • Yes, stem cells are the pristine cells of the body, which can give rise to many different types of cells upon proper signalling. In case of eye disorders, these cells have shown remarkable improvements by differentiating into photoreceptor cells, rods and cones cells of the inner eyes, optic nerve cells, etc. This differentiation is achieved very naturally with minimum manipulation outside the body, using autologous stem cells sources such as bone marrow or adipose tissue
  • Where can I get more information about Disease?
  • Please go through, our Retinitis Pigmentosa, Glaucoma, Macular Degeneration for other eye disorder related information.


What can you expect?

Many patients after stem cell treatment reported to be exhibiting:

  • Significant improvement in the vision
  • Reduction in pain
  • Improved eye movements in case of myopic patients
  • Complete stoppage or progression of the disease

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