Advancells

Is ALS linked to the environment ?

Clinical studies so far have not found definitive environmental factors that can be linked with ALS apart from some generalized studies relating it to the possible exposure of certain chemicals like lead or mercury.

ALS, which has been induced due to some environmental factors, is observed to be slightly more common in men than in women. However it has also been reported recently that the difference is decreasing over the time. At the same time, familial ALS i.e. ALS associated with the genetic variations is equally common in both the genders.

ALS is generally age related; most of the people find out that they are suffering with ALS when they are between 55-75 years of age.

Most of the people with ALS have observed to be living for 3 to 5 years after the symptoms can develop. Although the exact life of the person with ALS have been related to age.

It has been observed that almost about 5-10% of the total ALS cases are familial ALS i.e. they are mostly caused due to the defect in the gene which is commonly known as "SOD1"

ALS falls under a group of conditions known as motor neuron disease. In ALS, muscles involved in the voluntary movements of both upper and lower body are affected. On an average, ALS generally accounts for the 85% of motor neuron diseases.

Please go through, our ALS treatment brochure for other ALS related information.

The problems associated with the brain in Autistic children have their roots in early brain development during the embryonic stage of life, however, the most obvious signs and symptoms of the disease tend to be expressive between 12 to 18 months of age. In fact, some infants can even express them very late by the age of two to three years of life.

Autism prevalence has been identified to increase ten folds since the past 20 yrs. The centre for disease control has estimated ten million children to be affected worldwide. Studies have also shown that the disorder is more common in boys as compared to girls. It has also been observed that its prevalence is increasing 10 to 17 % each year. Although there is no established reason for this particular rise in prevalence over the year, however, improved diagnosis, diet and environmental influences are the reasons, seemingly responsible for its occurrence.

The science has identified rare genetic changes or mutation as responsible factors for this particular conditions. Research has identified more than 100 genes, the expression of which can result in an Autism. Additionally, a number of environmental factors are also identified to be increasing the risk of autism. They may include advanced parental age at the time of conception, maternal illness during the pregnancy, extreme prematurity, very low birth weight, certain difficult period of oxygen deprivation to the brain of the baby, during the birth,mothers exposed to high levels of pesticide, air pollution and unusual dietary habits such as alcoholism, smoking etc. All these factors are influencing the condition.

Although each autistic child is different, they can behave or react with a different perspective. Many of them can be exceptionally well in visual skills, music and academic skills. About 40% of them can have hampered intellectual disabilities with their IQ sector less than 70%. About 25% of them have significant disability and are unable to live independently.

There is no diagnostic test existing to detect the disorder, however, scientists are on the verge of detecting it at the earliest with the help of advanced imaging technology and differences in blood levels of proteins. diagnosis can involve parental inputs, structured and systematic screening of instruments measuring the prevalence of symptoms.

There is no fixed protocol of treatment available for the disease, however, it is always believed that early intervention allows the best outcome. At present rehabilitative therapies, approaches have been identified addressing cognitive and behavioural functioning. They may include a combination of medication, behavioural therapy, psychological education, family support, educational intervention, speech and language therapy etc. These treatments have been proved to be just supplementary without any significant improvements.

Please go through, our treatment brochures for other Autism related information.

Although the root cause is still unknown, the disorder is mainly associated with the genetic abnormality.

Involuntary tremors, shaking voice, nodding head, tremors that worsen during emotional stress and lessen with rest, difficulty with balance, muscular rigidity, changes in walking pattern and posture etc.

Conventionally drug therapy and physical rehabilitation approach were applied as a treatment for Parkinson's, however, the treatment did not prove to be effective in reversing the damage. Additionally, long-term use of steroidal medicine could be very fatal, welcoming other unwanted side effects.

Undifferentiated adult autologous stem cells are mutable and can metamorph into a countless number of cells as per the requirement. This remarkable property of stem cells can be exploited for treating a variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with the great speed to restore damaged neurons, regularize the production of neurotransmitters including dopamine to retain the brain’s normal function back. In addition to stem cell therapy, a stimulation therapy can also be applied, wherein the organ is stimulated to multiple resident stem cells and secrete growth factors to create microenvironment. This treatment will act as a booster to promote regeneration.

Conventional treatment approaches highly invasive associated with many side effects. Although stem cells can naturally heal the body from damage and regenerate lost neurons to improve impaired functions. Additionally, since the body’s own cells are used for repairing, the entire treatment is minimally invasive without any side effects.

There are many important issues to be addressed before opting for the treatment, which can satisfy answered only by experts. Thus, it is always advisable to consult and opt for the right stem cells treatment pattern.

Please go through, our treatment brochures for other Parkinson’s Disease related information.

There are several different types of cerebral palsy: spastic diplegia, spastic hemiplegia, spastic quadriplegia, athetoid dyskinetic cerebral palsy, choreoathetoid dyskinetic cerebral palsy, dystonic dyskinetic cerebral palsy, ataxic cerebral palsy, hypotonic cerebral palsy, and mixed cerebral palsy.
The spastic forms of CP are characterized by stiff muscles and muscle spasms. The dyskinetic forms of CP are characterized by involuntary, writhing movements. Ataxic CP, the least disabling of all the forms, is characterized by balance and depth perception problems which make walking difficult. Hypotonic CP is characterized by overly relaxed, "floppy" muscles. As the name implies, mixed CP is characterized by symptoms of two or more forms of the disorder.

The answer depends on the type of CP and the extent of the brain damage or brain malformation which caused it. Impairment from CP ranges from mild to severe. Many people with cerebral palsy lead nearly normal lives, while some CP patients require constant care from others throughout their lives.

Cerebral palsy is caused by brain damage or brain malformations. Occasionally genetic abnormalities cause the brain to develop abnormally, but most cases of brain malformation are due to other factors. Exposure to toxins can interfere with the proper development of the unborn baby's brain. Damage to the white matter of the brain is particularly likely to lead to CP. Between 26 and 34 weeks gestation, the unborn baby's brain is especially vulnerable to injury to the white matter, but damage can occur at any point in the pregnancy.

Infections in the mother or in the unborn baby can lead to brain damage. The inflammation produced as a normal part of the infection-fighting process can cause damage to the baby's developing brain cells. Infections can also trigger strokes in the fetus, leading to oxygen deprivation; prolonged oxygen deprivation can cause brain damage which leads to CP.

Uncontrolled high blood pressure in the mother during pregnancy puts the fetus at higher risk for a stroke. Extremely low maternal blood pressure can also put the unborn baby at risk for a stroke. Monitoring and controlling the blood pressure is a vital part of good prenatal care.

Rh incompatibility, a condition in which the fetus' Rh blood type conflicts with the mother's Rh blood type, can also cause cerebral palsy. Rh incompatibility leads to severe jaundice a buildup of bilirubin in the blood which can cause deafness and CP. a Fortunately, Rh incompatibility can be treated if caught in time. In the United States, testing for Rh incompatibility is a regular part of prenatal care, but this is not the situation in many other countries. If you are pregnant, make sure your doctor checks for Rh incompatibility as early as possible in the pregnancy.

Severe jaundice caused by problems other than Rh incompatibility can also lead to CP. Jaundice is common in newborns, but it can be treated.

Some cases of brain malformation are due to gene abnormalities which prevent the brain from developing normally, but this is rare. Most cases of CP are not in anyway hereditary but are due to factors which occurred during the course of the pregnancy.

The term congenital means present at birth. Between 90 to 95 percent of CP cases are congenital. Congenital CP includes those cases which were caused by oxygen deprivation during birth. Doctors used to believe that most cases of CP were caused by a lack of oxygen during a difficult labour and delivery, but it is now known that fewer than 10 percent of congenital cerebral palsy cases stem from asphyxia or other problems during birth. The majority of problems that cause CP occur during development in the womb. Brain trauma, infections, strokes, and other problems after birth can occasionally cause acquired CP. As the name implies, acquired CP means that the condition was acquired after birth.

Alcohol consumption during pregnancy raises the risk of complications which can cause cerebral palsy and many other birth defects. There is no established safe level of alcohol consumption during pregnancy, so pregnant women should avoid alcohol entirely.

Babies born prematurely are at a higher risk for cerebral palsy. Modern medical techniques save a higher percentage of premature babies, but these babies are more prone to developing disabilities than full-term babies are. Babies with a low birthweight are also more at risk for cerebral palsy, even if they are full-term.

Women with mental retardation, a seizure disorder, or a thyroid disorder are slightly more likely to have a baby with CP, than women who do not have these conditions.

According to the National Institute of Neurological Disorders and Stroke, approximately two-thirds of patients with CP have some mental impairment. Mental retardation can range from mild to severe. People with the spastic quadriplegia are more likely to have mental disabilities than those with other forms of CP. CP patients with epilepsy are also more likely to have mental retardation. Because of communication difficulties, it is sometimes difficult to accurately assess the IQs of CP patients. Learning disabilities without mental retardation are also associated with cerebral palsy. The speech, hearing, and vision problems which sometimes accompany CP can make learning difficult. Many CP patients have normal IQs and no learning disabilities. A few CP patients are intellectually gifted.

Cerebral palsy is not a terminal condition, but before the advent of newer medical techniques in the mid-twentieth century most children with CP did not live into adulthood; complications from the disorder claimed their lives. Today, between 65 and 90 percent of children with cerebral palsy reach adulthood. CP is stressful for the entire body and can cause premature ageing, particularly of the heart, blood vessels, muscles, joints, and bones. The complications stemming from CP can be life-threatening. Cerebral palsy can lead to respiratory and swallowing difficulties. Difficulty swallowing can lead to malnutrition and/or aspiration pneumonia in which food is inhaled into the lungs causing an infection. Malnutrition causes weakness and muscle deterioration; it weakens the immune system making the patient more vulnerable to infections and less able to fully recover if an infection occurs. CP patients whose mobility is extremely restricted may have to sit or lay down for extended periods of time, running the risk of pressure sores. Untreated pressure sores can develop life-threatening infections. The bowel and bladder problems frequently associated with CP can lead to more serious complications when not properly managed.

Cerebral palsy cannot be cured. The brain damage or brain abnormalities from which it stems are irreversible. Fortunately, today much can be done to improve the quality of life for CP patients.

Can cerebral palsy be prevented?

Extensive research is being done on cerebral palsy treatment and prevention. Much of this research is funded by the National Institute of Child Health and Human Development, the National Institute of Neurological Disorders and Stroke, and private organizations such as the United Cerebral Palsy Research and Educational Foundation. Research is being done on brain development in hopes of learning what can be done to prevent brain abnormalities from developing. Scientists are also studying the role uterine infections play in the development of CP. Other research centers on finding new ways to diagnosis CP earlier, so that treatment can be begun as quickly as possible; early treatment leads to better outcomes for CP patients. In addition, research is being conducted on the various methods of physical therapy used for CP to determine which methods are most effective and to develop better technology to utilize with these methods. For example, functional electrical stimulation of the muscles can help strengthen spastic muscles, but the technique uses bulky implanted devices; research is being done on using a hypodermic needle to inject small devices at the necessary sites, thus making this therapy more practical and affordable.

Undifferentiated adult autologous stem cells are mutable and can metamorph into countless number of cells as per the requirement. This remarkable property of stem cells can be exploited for treating a variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with the great speed to restore damaged fibres, regenerate neuron as well can improve damaged function.

Conventional treatment approach is highly invasive and associated with many side effects. Whereas stem cells can naturally heal the body from damage and regenerate lost neurons to improve impaired functions. Additionally, since the body's own cells are used for repairing, the entire treatment is minimally invasive without any side effects.

Please go through, our treatment brochures for other Cerebral Palsy related information.

Stem cells transplantation is of different types ranging from allogeneic mesenchymal stem cells, umbilical cord blood-derived stem cells, autologous bone marrow and fat-derived stem cells, etc. However, out of these, autologous mode of stem cell transplantation is known to be the most useful as body's own cells are used they don't impose any threat of rejection of infection.

Stem cell injection can start showing results in one injection itself, although it is difficult to interpret because the therapeutic efficacy of this treatment depends upon the patient's condition depending upon the uptake of stem cells, severity of the disease and age of the patient.

Rehabilitation in terms of physical exercise is necessary, however strenuous way of physical exertion should be avoided. Considering steroidal therapy, it has always been proven to be medically subjective and limited in usage and hence their long-term use needs to be avoided. The main goal of the steroids is to reduce inflammation during muscular dystrophy. However, their long-term use can have an impact on the overall physical fitness of the patient.

Stem cells isolated from autologous tissue sources along with antioxidant stimulation can improve the muscular strength by regenerating muscle cells. The development has been observed in various clinical trials. However, the results may vary from person to person.

There are 50% chances of DMD deformities in your younger son. However, it has to be confirmed by molecular diagnostics and other tests. The stem cells therapy can work better in younger patients than an older one. The earlier you can opt for the treatment, you will get better outcomes.

Undifferentiated adult autologous stem cells are mutable and can Metamorph into countless numbers of cells as per the requirement. This remarkable property of stem cells can be exploited for treating a variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with greater speed to promote regeneration of muscular cells, to help control over your mood swings, to improve the physical fitness and overall mobility. Additionally, a stimulation therapy can also be applied, wherein the organ is stimulated to multiply the resident stem cells and secrete growth factors to create microenvironment. This treatment will act as a booster to promote regeneration.

The conventional treatment approach is highly invasive and associated with many side effects. Although stem cells can naturally heal the body from damage and regenerate lost tissue-specific cells to improve impaired functions. Additionally, since the body's own cells are used for repairing, the entire treatment is minimally invasive without any side effects.

There are many important issues to be addressed before opting for the treatment, which can satisfactorily be answered only by experts. Thus, it is always advisable to consult and opt for the right stem cell treatment pattern.

Please go through, our treatment brochures for other MD related information.

A person with his early disease developmental stage may find difficulty in remembering things, he can ask the same questions again and again, have trouble managing finances, taking longer than normal to finish daily tasks. A person may also face difficulty in finding the right words in his speech, impaired reasoning or judgmental abilities. He or she may as well experience mood swings or personality changes.

Except for a rare form of Alzheimer, called early onset familial Alzheimer's Disease other forms of diseases are non-genetic. Genetic mutations are linked with the type of an Alzheimer, whereas others are directly linked with environmental factors and traumatic situation faced by the body.

The only way to diagnose a disease is to find out whether plaques and tangles are present in the section of the brain. To look into the tissue, the doctor has to perform brain biopsy test or brain autopsy test, an examination of the brain done after the person dies. When the person is alive, the diagnosis is fully dependent upon the possibility or probability through examination of general health, past medical problems, family history, asking questions about personality changes, memory tests, language skills, problem solving capacity, attention.

Although the time from diagnosis to death varied from person to person, it can be as little as 3 to 5 years for the person above 80 years of age. For younger patients, time may vary between 7-10 years.

Please go through, our treatment brochures for other Alzheimer's Disease related information.

No, MS is not contagious neither it is directly inherited. Studies have indicated a mixed effect of both genes and environmental factors on the development of MS. Research has evidently suggested that susceptible individuals may have a familial genetic contribution for MS, however, these individuals need to encounter some triggering factor from the environment to actually develop MS. The research is still underway to pinpoint the exact location of the causative gene, its environmental cause, prevention and better treatment.

In general, MS is not considered a fatal disease, but the quality of life can be significantly affected in patients suffering from Multiple Sclerosis. As such, there is no known full proof treatment available to reduce the sufferings. However, many therapeutic and technological advances are made in the field of stem cells to find a cure for the disease.

Yes, stem cells are the pristine cells of the body, which can give rise to many different types of cells upon proper signalling. These cells have been exploited successfully to differentiate into neurons. They have been isolated from the very own potent sources of our body known as Bone Marrow and Adipose Tissues. They can be minimally manipulated and implanted back into the body to promote neuroregeneration. They have also identified to be an effective guiding immune system to distinguish self-tissue from the non-self, thereby reducing further destruction.

Please go through, our treatment brochures for other Multiple Sclerosis related information.

During a stroke, a bystander should know the signs and act accordingly in time. If signs and symptoms of strokes are confirmed, like the person is losing an ability to speak, moving an arm or leg on one side or is experiencing facial paralysis on one side, then support him to avoid any physical injury. Ask someone to arrange for the ambulance as quickly as possible.

While hereditary factors play a role in the risk of stroke. There are many things, you can actually incorporate in your lifestyle to help reduce the risk of stroke such as avoiding smoking, excessive alcoholism, improved eating habits, regular exercises etc.

The chances of stroke increases with the age and genetic make up. Comparatively older people and men are at a greater risk of stroke as compared to their counterparts. People from African and American continents are five times more likely to have a stroke as compared to others. How can stem cells treatment help stroke patients?
Stem cells are the master cells of the body, which are able to differentiate into variety of cells if channelized properly. Stem cells isolated from autologous body sources such as Bone Marrow or Adipose Tissue are observed to be superior in vascularization i.e. formation of new blood vessels, clearing obstructed blood flow and regenerating dead cells. Various clinical trials have shown good improvements in patients.

Stem cells are the master cells of the body, which are able to differentiate into variety of cells if channelized properly. Stem cells isolated from autologous body sources such as Bone Marrow or Adipose Tissue are observed to be superior in vascularization i.e. formation of new blood vessels, clearing obstructed blood flow and regenerating dead cells. Various clinical trials have shown good improvements in patients.

Although, sooner is the better but depending upon the physical evaluations, doctors can tell you the best possible way through which you can avail this treatment.

Please go through, our treatment brochures for other Stroke related information.

Any amount of alcohol can produce damage to the liver, however the general thumb rule for an otherwise healthy person can be 3-4 drinks a day for men and 1-2 drinks per day for women, since men metabolize and are able to clear alcohol very efficiently than women due to body size, body fat and certain enzymes. However, if an individual has underlying liver conditions such as hepatitis B or C or liver damage, the liver can be very sensitive to alcohol, and in that case, the only safe dose of alcohol is zero.

The liver cirrhosis is the liver disease, characterized by widespread destruction and degeneration of liver tissue often marked with an increase in fibrotic connective tissue. The liver has always been in a tendency to regenerate on its own, however, due to regular degeneration and regeneration process, it forms structural nodules leading to permanent alteration of its structure and function, due to scarring and increased formation of the connective tissue. It needs immediate medical attention to prevent further consequences of a damaged liver.

Our liver is normally a silent organ, suffering silently for a longer period of time, however, if you suddenly suffer from stomach pain or stomach upset, you need to visit the doctor. Apart from that, sudden exhaustion, bloated stomach, morning sickness and glassy eyes with red and blue blood vessels under the eyes are the alarming signals when you need to visit the doctor.

Yes, medication which contains steroids and their long-term use can be harmful to the liver. Similarly, birth control pills with a high level of oestrogen can also be dangerous and hence should be avoided.

Yes, to some extent, the liver is a regenerative organ, liver cells regenerate minor injuries on its own, however, their potency is limited to cope up for the major damage and hence it is always advisable to visit the doctor if you notice the warning signals of the liver damage.

At present stem cell treatment can be offered from a variety of sources such as umbilical cord blood, tissue mesenchymal cells, autologous sources etc to reverse the damage associated with the disorder, however, the safest amongst them can be an autologous way as the body’s own cells have been used. There are least chances of immune rejection and other infection. Additionally, these sources are readily available within you and you need not have to wait for the right match. This, in turn, saves a lot of time and complications.

Since the stem cells treatment is progressing rapidly, every day it comes up with the new discovery, however, currently patients have been reported to get improved metabolism, improved stamina, minor complaints have been resolved such as pain, constipation, vomiting. Additionally, no cases have been reported to be damaged further after stem cells transplantation. Thus rather than wasting time, money and health, you can always go for stem cells transplantation, but you can’t expect your liver to be working naturally.

Please go through, our treatment brochures for other Liver Diseases related information.

The most commonly listed risk factors associated with the disorder can be age, smoking, overweight, diabetes, high blood pressure, high cholesterol etc.

Intense chest pain, pain in the left arm or jaw and difficulty in breathing. Women may show the same symptoms but her pain may be more diffuse, spreading the shoulders, neck, arms, abdomen and even her back. They may experience discomfort like indigestion. There could also be unexplained anxiety, nausea, dizziness, palpitations and cold sweat.

Conventionally Angioplasty, Stents or bypassing the artery through surgery are prescribed depending upon the severity of the disease. However recovery or reversal of damage is not guaranteed, additionally, these approaches are associated with many side effects.

Undifferentiated adult Autologous stem cells are mutable and can metamorph into a countless number of cells as per the requirement. This remarkable property of stem cells can be exploited for treating a variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with the great speed to restore damaged fibres, improve vascularization to bypass the blocked artery as well can improve damaged function.

Conventional treatment approach is highly invasive and is associated with many side effects. Stem cells can naturally heal the body from damage and regenerate lost tissue or cells to improve impaired functions. In the case of heart disorders, they can promote angiogenesis, regenerate lost cardiac cells to normalize the heart function. Additionally, since the body's own cells are used for repairing, the entire treatment is minimally invasive without any side effects.

Please go through, our treatment brochures for other Cardiovascular Disease related information.

People with uremia can avoid the problems associated with it by opting for regular dialysis and limiting food containing salts such as sodium, potassium and phosphorus. They are also advised to visit a specialist called a nephrologist regularly, to track the progression of the disease.

Hemodialysis is a kind of dialysis that uses a machine to circulate blood through a filter outside the body. It has also been observed that for many of the patients, a rapid change in the body's water and mineral balance can cause a problem. Some of the patients can also complain about weakness, dizziness, stomach pain etc. due to the common side effects of dialysis such as muscle cramps and hypotension.

• Anaemia is another condition, affecting a person with kidney failure apart from uremia. Anaemia is a condition, in which the red blood cells are fewer or smaller than normal, carrying less amount of oxygen to the body's cells. The condition can also be associated with extreme fatigue and aggravation of heart problems.
• The root cause of an Anaemic condition has been linked with decrease production of the hormone erythropoietin due to decreased kidney function. Erythropoietin is responsible for the production of red blood cells in bone marrow.

Due to reduced absorption, removal of waste products and long-term use of steroids; it has been observed that patients with acute or chronic kidney failure report severe blockage to the artery and other blood vessels leading to congestive heart failure.

Many people, who are on dialysis complain about itchy skin, usually on the back, chest, head or limbs. This is itching is normally worse during or after dialysis, due to the deposition of waste products that are not removed from the blood. The problem can also be due to the damaged kidney's inability to balance the level of minerals, calcium and phosphorus. The itching is principle side effect of increased production of parathyroid hormone, which can cause itching.

As already discussed, kidney failure can throw off the balance of calcium, phosphorus and sodium resulting in an increased production of parathyroid hormones. These high levels of hormones, draws calcium from the bones into the blood, leaving the bones without enough calcium. The kidney failure can also cause pain, stiffness and fluid buildup in the joints due to a condition is known as " amyloidosis". The condition is generally associated with abnormal deposition of a protein known as Amyloids. It is observed that healthy kidneys are naturally able to filter amyloids but dialysis filters are not. Additionally, many patients who have been on dialysis for a longer period of time have reported insomnia and mental depression.

Conventionally steroidal drugs, hormone supplements and exposure to UV lights were offered along with the dialysis to reduce the symptoms associated with kidney failure. However, the treatment that has been offered can be dangerous with many possible side effects as discussed earlier.

Stem cells are the mother cells of the body, which are able to differentiate into many new cells upon proper activation. Through various clinical trials, it has been observed that they can be successfully differentiated into kidney cells or proximal epithelial cells of the inner lining of the kidney. By offering the stem cells solution, doctors can minimize the side effects associated with dialysis and oral steroidal medicines. Since cells are isolated from body's own tissues such as Bone Marrow or Adipose Tissues, there is no chance of immune rejection as with kidney transplantation and hence can be the safe alternative.

For more information on Kidney failure and problem associated with it, you can always refer to our Treatment Brochure of Kidney Disorders.

The disease develops gradually and some of the common symptoms associated with the disorder are fatigue, extreme thirst, frequent urination, extreme hunger, weight loss, frequent infection, slow wound healing, blurry vision.

Several genetic and environmental factors such as hereditary link ups, diet, smoking, high BMI, age are related to the disease.

Diabetes can be routinely diagnosed with blood sugar testing and urine analysis. For the fast and quantitative assessments, doctors may also prescribe antibody tests and genetic tests.

Undifferentiated adult autologous stem cells are mutable and can metamorph into a countless number of cells as per the requirement. This remarkable property of stem cells can be exploited for treating a variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with the great speed to restore damaged cells, set up a microenvironment that can stimulate the secretion of growth factors, cytokines as a booster for regeneration.

Conventional treatment approach involves hormone therapies which were again associated with many side effects. Long-term use of steroids is also dangerous for welcoming many diseases. Additionally, if left untreated for a longer period of time, it can also give rise to diabetic foot, kidney damage and other physical problems.

Please go through, our treatment brochures for other Diabetes related information.

The most commonly listed risk factors associated with the disorder can be age, smoking, hereditary and environmental factors etc.

COPD is the medical condition and therefore typically requires long-term medications. The commonly used treatments for COPD are the use of bronchodilators, inhalers, oral steroidal medications, ventilators, surgery. However, these are either supplementary treatments or treatments with many side effects and hence for that matter, an alternative treatment with a complete reversal of damage is needed.

Commonly sputum tests, lung function tests are prescribed in order to assess that the person is suffering from COPD. Other than that chest X-ray and lung scanning is also suggested for some of the patients.

Undifferentiated adult autologous stem cells are mutable and can metamorph into a countless number of cells as per the requirement. This remarkable property of stem cells can be exploited for treating a variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with the great speed to restore damaged cells, set up a microenvironment that can stimulate the secretion of growth factors, cytokines as a booster for regeneration.

Conventional treatment approaches are highly invasive associated with many side effects. Although stem cells can naturally heal the body from damage and regenerate tissues or cells to improve impaired functions. Additionally, since the body’s own cells are used for repairing, the entire treatment is minimally invasive without any side effects.

Please go through, our treatment brochures for other COPD related information.

As firmer erection, has always been a combined action as a result of the whole series of psychological and physical events, it is associated with both the reasons.

With the current reported data, many men suffer from this issue, however, on a generalized note, men with Erectile Dysfunction wait for 5 years before going to the doctor. Due to changes in their lifestyle pattern, eating habits and stress, it is observed to be more widely spread than a normal man could imagine. A person with ED, should not take the disease very lightly, as it may give rise to other complications such as diabetes.

The most common cause of ED is damaged to arteries, smooth muscles and fibrous tissues. The problems related to them can be caused by a variety of factors like diseases such as atherosclerosis, diabetes, multiple sclerosis, kidney diseases etc. Penile injuries may also lead to major troubles. Additionally, complications with surgery or radiations can interfere with nerve impulses or blood flow to the penis. ED can also be the result of a side effect of common drugs taken for high blood pressure, antidepressants, tranquillizers, etc. Chronic use of alcohol, tobacco etc. can also cause ED aggravated by decreased sexual life.

Psychological problems, such as anxiety or depression may interfere with the men erection process by distracting him from things that normally arouse him. These problems can be listed out as depression, relationship problems, anxiety, stress etc.

Yes, it does, especially if it was due to the result of a stressful situation which has been resolved or an injury that has been healed.

Medical practitioners can understand your problem and can identify the root cause of it. He can also guide you to get over your mood swings or depression. It is always better to face the problem rather than hiding it. However, it is necessary to find the right person and right place with whom you can completely rely on.

Conventionally, steroidal drug therapies, surgical methods were used to rectify the problem associated with the disability. However, the long-term use of these steroidal drugs can be very dangerous and can welcome some unknown side effects. However, these treatments proved to be very temporary with no reversal of damage and hence an alternative treatment was always in demands, that can reverse the damage associated with the disorder.

Undifferentiated adult autologous stem cells are mutable and can Metamorph into countless numbers of cells as per the requirement. This remarkable property of stem cells can be exploited for treating a variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with greater speed to smooth obstructed blood flow, to promote networking of new blood vessels, to help control over your mood swings, etc. Additionally, a stimulation therapy can also be applied, wherein the organ is stimulated to multiply the resident stem cells and secrete growth factors to create microenvironment. This treatment will act as a booster to promote regeneration.

Conventional treatment approach is highly invasive associated with many side effects. Although stem cells can naturally heal the body from damage and regenerate lost tissue-specific cells to improve impaired functions. Additionally, since the body's own cells are used for repairing, the entire treatment is minimally invasive without any side effects.

There are many important issues to be addressed before opting for the treatment, which can satisfy answered only by experts. Thus, it is always advisable to consult and opt for the right stem cell treatment pattern.

Please go through, our treatment brochures for other Erectile Dysfunction related information.

No, there is not yet any scientific evidence that these instruments emit rays that can be harmful to the eyes, however long working hours can be tiresome and hence it is often helpful to take periodic breaks, looking off in the distance etc.

These are the common eye problems which are indications of retinal or corneal malfunctioning. It is always advisable to visit the doctors as early as possible.

The ability to focus the near objects decreases with age and is referred to as presbyopia. The condition is known as the natural aging of the optic lens. The condition is often irreversible with conventional treatments, however, stem cells can to some extent reverse the damage naturally, with the complete stoppage of further progression.

Yes, some of the eye disorders such as glaucoma, photophobia etc. are observed to be directly linked up with a genetic abnormality which can either be hereditary or mutational. However, some of the common eye problems such as burns, corneal damage, etc. are linked to environmental damage.

No, there is no evidence currently to transplant the whole eyes, however, part of the eye can be replaced if a suitable donor is found.

Yes, stem cells are the pristine cells of the body, which can give rise to many different types of cells upon proper signalling. In the case of eye disorders, these cells have shown remarkable improvements by differentiating into photoreceptor cells, rods and cones cells of the inner eyes, optic nerve cells, etc. This differentiation is achieved very naturally with minimum manipulation outside the body, using autologous stem cells sources such as bone marrow or adipose tissue

Please go through, our Retinitis Pigmentosa, Glaucoma, Macular Degeneration for other eye disorder related information.

Joint replacement surgery is performed to replace damaged joint with a new, artificial joint known as a Prosthesis. On an average, these joints have a lifespan of 10 years, however, it varies depending upon the usage and person's age.

A strain occurs when the muscle or tendon is stretched or torn. A sprain occurs when a ligament is stretched or torn.

In our lower back, nerves join to form the Sciatic Nerve; which runs down in the leg and controls the muscles of the leg. Sciatica is the condition that may cause a radiating pain, numbness, tingling and/or muscle weakness in the leg.

Impingement syndrome is a common disorder of the shoulder referring to an improper alignment of the bone and the tissues in the upper arm. Inflammatory conditions such as arthritis are closely related to the impingement syndrome.

Although osteoporosis is more common in women, atleast one in eight over 50 have the chances of getting osteoporosis. As with the declined testosterone levels in men can also lead to increased chances of bone loss.

Osteoporosis can be prevented by reaching the peak bone mass, during the childhood and teenage years. Few habits can be incorporated in order to increase bone mass such as enough calcium and vitamin D uptake by drinking milk and milk products, regular exercise, avoiding milk and milk products, avoiding smoking and excessive alcohol consumption.

Yes, stem cells are the pristine cells of the body, which can give rise to many different types of cells upon proper signalling. These cells have been exploited successfully to differentiate into neurogenic, osteogenic and chondrogenic lineages. They have been isolated from the very own potent sources of our body known as Bone Marrow and Adipose Tissues. They can be minimally manipulated and implanted back into the body to promote neuro-regeneration, bone reconstruction, reformation of tendons and cartilages.

Please go through, our treatment brochures for other Orthopaedics related information.

The most common causes of spinal cord injury are motor accidents, serious fall, acts of violence, sports injury and recreation accident, diseases such as spina bifida can also cause permanent injury to the spinal cord.

Paraplegia is a term used to describe the inability to move and sense the lower part of the body from the waist down, whereas the term tetraplegia or quadriplegia includes loss of motor and/or sensory function in the upper body, arms and hands.

This could be because sensory but not motor function is preserved below the neurological level and includes the sacral segments S4-S5, AND no motor function is preserved more than three levels below the motor level on either side of the body. Therefore he has sensation in his legs but the loss of motor function. All this dependant on Complete or Incomplete Injury to spinal cord i.e the amount of movement and sensation that has been lost during the trauma. Understanding the extent of the injury is the best-known indicator of what to expect in the recovery of function from injury.

The Central Nervous System is the most complex network of nerves in the body. Till date, even scientists are the mysteries of the brain and its network. However, the discovery of Stem Cells in modern science holds great promise in treating Spinal cord injuries. Stem Cell transplantation directly into the injured site leads to the generation of new nerve cells resulting in possible repair of axons and transmission of nerve signals. It has also been seen that Stem Cell transplantation given within few hours of Spinal Cord Injury can reduce the damage by releasing protective substances such as growth factors, and soaking up toxins such as free radicals, when introduced into the spinal cord shortly after injury and also preventing the spread of disease by reducing inflammation in the injured area.

Please go through, our treatment brochures for Spinal Cord Injury related information.

• The Bath Ankylosing Spondylitis score measures the main symptoms of Ankylosing Spondylitis such as fatigue, back pain, morning stiffness. The score is recorded out of 10, more is the score, worst are the symptoms.
• The Bath Ankylosing Functional Index is scored according to how much your disorder is affecting your ability to carry out day to day tasks.
• The work productivity and activity score measures your ability to work during the last week, be it in a job or home.

Additionally, other clinical assessments are done such as spinal X rays, Specific blood tests like haemoglobin, ESR and CRP.  Specific genetic tests may also be done including HLA-B27, RA, etc. The patient may also be prescribed some other radiological confirmations such as MRI, X-Ray, CT Scan, etc.

There may be

Bruising and bleeding Sprains (ligament tear) causing pain, swelling and inability to move joints and strains (tendon/muscle tear) causing muscle spasm and pain Wounds and fractures Head and/or spinal cord injury Dislocated joints: mostly hand joints and the shoulder joint

• Knee injuries: caused due to too much running without proper warm up, twist, blow or improper landing after a jump. There may be rupture of knee tendons, cartilage and ligaments.
• Shin splints or pain the bone of the lower leg, commonly seen in runners due to overuse or incorrect use of the lower leg, overtraining, improper stretching, etc.
• Achilles tendon injuries caused due to tear of the tendon connecting calf muscle to the back of the heel. It occurs due to improper stretching, overuse, aging, etc.
• Rotator cuff injuries: injury to the muscles and tendons of the shoulder, they are caused due to overuse, aging, repeated overhead motion, falling on an outstretched hand, etc.

• Children and Adolescents: as their muscles, tendons and bones are still growing and thus are more prone to injury
• Middle Aged Sports Person: as they lack agility and resilience that a young athlete possesses
• Women: due to osteoporosis, fluctuation in hormone levels caused by menstruation, etc.

1. Platelet-rich plasma contains a high level of platelets, clotting factors, cytokines, and growth factors. They start releasing these activated factors 10 minutes after clotting, and more than 95% of growth factors are released in the first hour. Platelet-rich plasma is stable for approximately 8 hours after preparation [1,2]
2. TGF-b and PDGF in PRP are triggers for cell growth and differentiation leading to early wound healing.
3. bFGF, PDGF, IGF, and EGF in PRP increases epidermal regeneration
4. Collagen synthesis and maturation increases due to PRP applications leading to an increase in collagen deposition that helps in speedy recovery.
5. Enhances wound healing, promoting epithelization and angiogenesis.

1. PRP is generated from patients own blood hence immunologically neutral with no cross/hyper reactivity as are easily acceptable by patients body.
2. Blood Collection, PRP separation and activation including PRP gel preparation is carried out in completely sterile conditions in GLP compliance laboratory. Hence PRP gel application does not lead to infection.
3. PRP may be injected intralesionally or perilesionally or in the form of a platelet gel and used topically.
4. Intradermal injections of PRP at the wound site may cause inflammation with or without nerve trauma in rare cases.

1. Pallua N, Wolter T, Markowicz M: Platelet-rich plasma in burns. Burns, 2010; 36(1): 4–8 4.
2. Yol S, Tekin A, Yilmaz H et al: Effects of platelet-rich plasma on colonic anastomosis. J Surg Res, 2008; 146(2): 190–94
3. Kazakos K, Lyras DN, Verettas D et al: The use of autologous PRP gel as an aid in the management of acute trauma wounds. Injury, 2009; 40(8): 801–5
4. Loot MA, Kenter SB, Au FL et al: Fibroblasts derived from chronic diabetic ulcers differ in their response to stimulation with EGF, IGF-I, bFGF and PDGF-AB compared to controls. Eur J Cell Biol, 2002; 81(3): 153–60

Platelets are known as the first respondents after the injury. Immediately after the injury, the human body starts eliciting an immune response allowing platelets and other immune components to migrate at the site of injury. At the targeted site, these platelets are known to secrete various growth factors and clotting factors to initiate the healing process, promote blood vessels formations as well as collagen synthesis. These platelets are also known to trigger the secretion of many bioactive molecules, which can attract many macrophages, mesenchymal stem cells and osteoblasts. PRP is a healing therapy used in the field of regenerative medicines to stimulate and enhance healing. In a simple language, PRP is considered as the mega doses prepared from the ingredients of our own body for our own healing.

Based on the current research, all the orthopaedic related problems such as soft tissue injuries, tendonitis, ligament sprains and muscle tears can be treated well with PRP therapy. It is as well found to be very useful in the treatment, hair restoration and wound healing such as the diabetic foot.

A patient typically tolerates the therapy well both with and without anaesthesia. However, post-injection swelling in expected given the PRP induced inflammatory response. But these discomforts such as swelling are observed in the typical injected area which will not be for more than 48 hrs.

Many of the people have noticed some or the other kind of improvement depending upon the problem by 2-3 weeks after the PRP therapy. Symptom improvement has been observed to be slow and subtle with the passage of time, with usual complaint of original pain being replaced by the soreness. Increased endurance and strength are typical observation immediately after the treatment.

A small amount of blood is withdrawn generally 30 ml from the peripheral vein of the patient. The blood is then placed in the centrifuge, to separate platelet from the rest of the components. On the therapeutic aspects, platelet count is enriched 5 fold with 10-15 fold decrease in the volume after the processing. The entire process takes not more than 20 mins to increase the concentration of platelet along with the inherent stimulation of stem cells for quick proliferation, differentiation and regeneration. The concentrated PRP is then injected around the area or in the joints to speed up the process of healing.

Over the past five years, we have standardized our protocol, according to individual needs of each patient; accordingly, we have ensured the best results from our therapy. You can expect below mentioned pronounced improvements that have noted in almost 70% of our treated patients, to more or less extent.

• Higher energy levels and stamina
• Firmer and tightened skin, improved hair structure as well as hair growth
• Better memory, quick mental response
• Subsidized muscular, joints as well as back pain
• Improved skin texture
• Better sleep and elimination of chronic fatigue

We offer novel anti-ageing therapy using a very natural and holistic approach. Our autologous stem cells programme is aimed at both the prevention of premature ageing and age-related diseases. In this regard, people applying for our anti-ageing therapy are those who:

• Are in good health or have minor health related issues, but would like to feel and look even better.
• Have no major health conditions but suffer from chronic fatigue, headaches, muscle pains, etc.
• Aim to delay the process of ageing, prolong their active lifestyle and prevent age related issues.

Yes; however, the level of necessary sedation depends upon several factors, including but not limited to patient’s health and medical history, what procedure does patient want to undergo as well as the necessity of the sedation. On a generalized note, many patients don’t require any high level of sedation during cosmetic dental problems.

Studies have indicated that smoking is the leading cause of tooth loss, due to different bone related and craniofacial complexities. Smokers come under the high-risk zone, for many dangerous conditions, like leukoplakia, loss of bone structure, inflammation of salivary glands, development of lung, throat, oral cancer, etc. Thus, they have to face an additional risk of considerations, when exploring cosmetic treatment due to defective gum health.

Although, the number of visits varies from patient to patient, but person would be able to notice overall oral health improvement and appearance in just a single visit. Although, science and technology are working hand in hand to make these treatments, as convenient as possible; to make them available routinely.

Yes, with good home care and regular visits to our specialists; modern materials that have been used for a procedure can last for many years, even possibly for decades. Thus, like most clinical procedure do; even cosmetic dentistry demands excellent maintenance.

• Early or late loss of baby teeth
• Difficulty in chewing and/or biting
• Crowded teeth
• Joints that make sounds
• Overbite and/or Underbite
• Excessive spaces between the teeth

A craniofacial region is primarily comprised of a framework of bones and cartilages, giving support to muscles, ligaments, glands and various other soft tissues, including skin and subcutaneous layers. Apparently, all these elements are innervated by the body’s most sophisticated neurovascular network, allowing for its complete functional as well as sensorial capabilities. Various injuries caused as a result of trauma, tumor, cyst development, infectious disease spreading and/or congenital as well as other developmental conditions may result into serious functional, aesthetic as well as psychological sequelae. In this regard, structural loss of hard and soft tissues can be often disfiguring and compromising; thus, hampering basic functions, like mastication, speech, swallowing and also in thermal and physical protection.

Stem cells are known to be the most potent cells in our body with the ability to retain their number back, through mitotic cell division and can undergo directed differentiation into variety of other specialized cells. Mesenchymal stem cells isolated from dental pulp tissue are found to be very helpful in guided tissue regeneration in the craniofacial cavity. However, it has as well been very apparent in different bench side studies that stem cells behavior and differentiation ability can be enhanced significantly through generation of suitable three-dimensional microenvironment. This microenvironment can be constructed through biomimetic scaffolds made up of All/Xeno/Auto substitutes in order to enhance and speed up the process of tissue reconstruction.

Being a very individualistic treatment, the total treatment time would obviously be dependent upon everyone’s specific problem with varied severity. In general, treatment time lasts from 8 months to 12 months.

Since, every orthodontic procedure includes permanent structural and functional changes in teeth and other facial tissues; it is very important that the specialist should be experienced and well aware of the latest technology to achieve, appropriate and desired results. Moreover, an orthodontic specialist to be chosen, should have extensive and specialized knowledge and expertise to offer very professional and specialized treatment plans.

Since, it is very difficult to accurately determine different treatment costs without clinically examining the patient; we would advise patients to undergo detailed consultation; wherein, we would assess the issue, through in person consultation, in order to evaluate the cost of treatment

• Missing more than one tooth, in the back of your jaw.
• Missing a significant amount of your bone in the back of your jaw.
• Missing teeth due to birth defect or some other congenital abnormalities.
• Missing many of the maxillary teeth, but require some support for further dental implants.

Various clinical investigations and statistical analysis have suggested various genetic as well as environmental factors to be responsible for the onset of gum disorders. In any case, below mentioned list of common causes can help you to prevent periodontal diseases, through proper precautions.

• Poor Dental Hygiene
• Usage of Tobacco
• Genetic Predisposition
• Pregnancy and menopause
• Chronic Stress and Poor diet
• Diabetes and underlying medical issues
• Grinding Teeth
• Medications

Since, these infections grow under the gums; they cannot trigger any symptoms at all.

Patients with more advanced periodontal disease, may experience some of the following symptoms:

• Swollen, red and/or tender gums
• Tooth sensitivity to heat and cold
• Bad breath
• Deep pockets around teeth
• Spaces between the teeth
• Loose and/or shifting teeth
• Missing teeth
• Gums receding around the teeth

Periodontal Disease is a gum and jawbone infection; accordingly, a treatment goal should be to remove infection, through natural integration of body’s own cellular mechanism and an extensive array of latest technologies to minimize procedural discomfort. Thus, combining regenerative potential of stem cells with biocompatible scaffolds, can be a promising strategy for natural development of diseased or damaged soft tissues, in the periodontal cavities, such as gums.

Today, a great smile can be listed as one of the primary attributes that reflects well on one’s personality; to have that positive impact from the social and professional aspects. Although, cosmetic dentistry is not just limited to the pretty smiles, but also about ensuring excellent, personalized care and better treatment outcome; hence, with new techniques and materials available with us, we are able to notice better functional outcome.

Dental implants can be used for:

• Single tooth replacement
• Multiple teeth replacement
• Full mouth reconstruction
• Stabilizing dentures

Since every individual is unique, the procedure that is being offered will also be very specific.

There are several factors, which determine the length and the treatment outcome.

They may include:

• Overall Dental Health.
• Number of teeth and type of teeth that are being replaced.
• Whether teeth need to be extracted and/or bone grafting needs to be done before procedure, etc.

As with any other dental procedure, there can be slight discomfort; the extent and severity of which, may vary from patient to patient. However, latest technologies that have implanted herewith are committed to make dental procedures, as pain free as possible. With reference to many of the reported incidences, slight swelling, bleeding can be experienced post treatment; however, it is reported to get subsided within few hours post treatment.

Stem cells are known to be the most potent cells in our body with the ability to retain their number back, through mitotic cell division and can undergo directed differentiation into variety of other specialized cells. Mesenchymal stem cells isolated from dental pulp tissue are found to be very helpful in guided tissue regeneration in the craniofacial cavity. However, it has as well been very apparent in different bench side studies that stem cells behavior and differentiation ability can be enhanced significantly through generation of suitable three-dimensional microenvironment. This microenvironment can be constructed through biomimetic scaffolds made up of All/Xeno/Auto substitutes in order to enhance and speed up the process of tissue reconstruction.

Dental implants should be cared just like your natural teeth. In general, it is advised to brush twice a day, flossing regularly to prevent further plaque formation and schedule routine dental examinations.

Since, it is very difficult to accurately determine different treatment costs without clinically examining the patient; we would advise patients to undergo detailed consultation; wherein, we would assess the issue, through in person consultation, in order to evaluate the cost of treatment.

• Loss of tooth
• Localized infection
• Gum Diseases
• Trauma