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Stem cell therapy for Alzheimer’s Disease

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We are harnessing groundbreaking power of regenerative medicine to treat Dementia/Alzheimer’s

We have excelled in transformative medicine using exosomes to regenerate functionally lost neurons

Stem Cell Treatment for Alzheimer’s Disease

Alzheimer’s Disease named after Dr. Alois Alzheimer, who first discovered it; is a complex neurological disorder with a series of biological and pathological characteristics. The neuropathological criteria for the effective diagnosis are through detection of protein bodies, known as Tau flakes; responsible for disrupting communication between the memory neurons. The indication is incurable with the conventional treatment modalities, but the systemic introduction of stem cells and exosomes together can bring beneficial symptomatic changes through fighting inflammation, reducing the deposition of protein flakes, and promoting neuroprotection.

Stem Cells Treatment for Alzheimer’s: Advancells Protocol

Alzheimer’s disease is a progressive neurodegenerative condition, characterized by the degeneration or functional damage of cognitive neurons, due to chronic pathophysiological insult. Earlier it was believed that the condition occurs only due to the deposition of unknown protein flakes, halting signal transduction pathways of cognitive neurons, resulting in their degeneration/damage due to loss of signal. However, with recent understanding of underlying pathophysiology and a more in-depth analysis of cellular communication have challenged the unidirectional approach to limited pathophysiological trends leading to Alzheimer’s disease.
While studies have indicated how mesenchymal stem cells and their cell-free derivatives, exosomes can control and regulate several pathways in time, space, and neuronal activity-dependent manner. With the approach, Advancells is also confirming the responsiveness of stem cells along with exosomes to a wide range of neuropathological processes, including degeneration via oxidative stress, neuroinflammation, aggregation of tau proteins, etc.

Procedure of Treatment of Alzheimer through Stem Cells Therapy

Treatment Qualification
Source Extraction
Processing of stem cells
Re-infusion
Today’s world of regenerative medicine is experiencing a paradigm shift from the reductionist view of “one disease-one target-one treatment” to the “One disease-multiple targets-one treatment” strategy. In this regard, Advancells is also adopting a multimodal therapeutic strategy by offering a combination of stem cells and exosomes.
Progressive loss of memory
Progressive loss of memory
Inability to learn new things or mental confusion
Inability to learn new things/mental confusion
Shortened attention span
Shortened attention span
Repeating questions
Repeating questions
Increased anxiety or aggression
Increased anxiety/aggression
Wandering or getting lost
Wandering and/or getting lost
Trouble concentrating
Trouble concentrating
Confusion and dizziness
Confusion, and/or dizziness
Restlessness
Restlessness
Cellular apathy
Cellular apathy
Changes in emotions
Changes in emotions
Memory loss
Memory loss
Increasingly inappropriate social behavior
Increasingly inappropriate social behavior
Lack of proper judgment
Lack of proper judgment
Repetitive compulsive disorders
Repetitive compulsive disorders
A decline in personal hygiene
A decline in personal hygiene
Loss of sensitivity towards others
Loss of sensitivity towards others
Depression
Depression
Depression
Depression
Rapidly worsening confusion
Rapidly worsening confusion
Disorientation
Disorientation
Difficulty in walking
Difficulty in walking
Muscle stiffness
Muscle stiffness
Double vision or hallucination
Double vision/hallucination
Confusion
Confusion
Lack of coordination in voluntary movements
Lack of coordination in voluntary movements
Memory loss
Severe memory loss
Visual changes
Visual changes
Disorders of the digestive tract
Disorders of the digestive tract
Disorientation
Disorientation
Alzheimer’s Disease or dementia, the progressive brain disorder, is not as easy to handle as it seems! The condition is often ignored as an aging disorder in the initial stage, but in an advanced stage, it can create a lot of turbulence in the lives of patients suffering from the condition and their family members. It is like a slow poison taking a toll on a person’s emotional,financial, and physical well-being. A lot of studies are going on to understand the age-related changes in the brain, turning out to be harmful to neurons and other types of cells, contributing to functional loss in Alzheimer’s, like atrophy, inflammation, vascular damage, production of free radicles, etc. Apart from the same, several factors may be involved noted herewith:
Causes of Alzheimers

CAUSES OF
ALZHEIMER
  • Certain viral infections may be responsible for hijacking information, creating the excessive formation of protein flakes leading to the development of dementia.
  • Long-term exposure to certain chemicals, toxins, and stress-associated free radicles can lead to the early development of dementia.
  • Other associated comorbidities like cardiovascular disorders, chronic diabetes, stroke, etc. are identified to be responsible for the rapid degeneration of brain cells causing dementia.
  • Certain types of environmental contaminants are identified to trigger inflammation; which in turn is responsible for the rapid degeneration of brain cells.
  • Certain types of mutations like MAPT mutations are responsible for altering the formation of tau proteins at the extracellular levels, leading to their unusual deposition at the intercellular junctions. A primary reason identified to be responsible for Alzheimer’s disease.
  • Genetic predisposition to certain mutagenic changes may result in the development of dementia.
We understand that with conventional medicine, there is currently no cure for Alzheimer’s disease, but there is a lot that can be done to enable someone to live well with the condition. Certain supportive treatments mentioned herewith are being suggested along with stem cell therapy to improve quality of life.
Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy It is breathing 100% oxygen, under increased atmospheric pressure to facilitate maximum reachability of oxygen towards the brain. The FDA has approved HBOT help to treat some brain and sinus infections, necrotic soft tissues, acute traumatic ischemia, skin grafts, etc.
Acupuncture
AcupunctureThe most preferred alternative for treating the majority of outcomes of dementia, of them is
behavioral disturbances. With more rigorous clinical interventions, more and more people with early and late phase dementia are being benefitted.
Hydrotherapy
HydrotherapyHydrotherapy has recently come up as a platform to regulate mental strength and balance while reducing the progression of neurodegenerative conditions like Alzheimer’s. It is a completely safe, low-impact exercise routine with higher benefits.
Sensory Motor training
Sensory-Motor trainingIt is a kind of mental stimulation process through interesting activities like dancing. It is mainly focused on the improvement of muscle strength, posture balance, coordination, short-term memory, as well as perceptual abilities.
Cognitive Stimulation
Cognitive StimulationIt is specifically designed for the elderly with a range of interesting activities, with a special provision for general stimulation for thinking, memory, concentration, etc.
Lifestyle Disorders
Lifestyle DisordersStudies have confirmed that being part of a heart-healthy lifestyle, includes daily exercise, eating a controlled diet, avoiding stress, and not smoking.

The field of stem cell therapy has witnessed improvements in neurodegenerative disorders like Alzheimer’s, through many clinical investigations. However, it is important to note that scientists are still working on small issues to pave the way for the effective treatment of AD and accelerate the pace of development. With this ongoing advancement worldwide, we are proposing a reversal, multimodal treatment objectives for the symptomatic management of AD.

Worldwide Clinical Studies using Stem Cells obtained from different sources

70% people have reported increased survival functions on an average with 87.76 months

With the help of our comprehensive environment and advanced technologies, we believe in building trust and transparency with our patients. So far, we have provided stem cell therapy for ALZHEIMER’S DISEASE to a number of patients and their clinical improvements have been amazing. Check out some of our patient testimonials:

  • Mr. Mrigen Sharma, 70 year old Alzheimer’s Patient

    19th December 2018: Mr. Mrigen Sharma, 70 year old Gentleman from Assam was diagnosed with Alzheimer’s in 2014. What started with forgetting simple tasks such as where the keys are kept …

  • Mr. Jagtej Singh, Age 70, Alzheimer / Dementia

    23rd February 2018: “I am thankful to you, at least you guys are trying to put an end to this disease,” said Mr Jagtej Singh, a vibrant young professional, who experienced the harsh…

  • Josephine Stramiello, Age 82, Alzheimer’s

    Year of birth: 1954, Marital status: Married, Disease treated: Alzheimer’s/Dementia Diagnosis, I was working as a teacher for more than 20 years before retiring. Was been diagnosed with Alzheimer’s in 2006 at the age of 60. I have had Alzheimer’s…

TYPES OF MND

Progressive loss of memory
Progressive loss of memory

Inability to learn new things or mental confusion
Inability to learn new things/mental confusion

Shortened attention span
Shortened attention span

Repeating questions
Repeating questions

Increased anxiety or aggression
Increased anxiety/aggression

Wandering and getting lost
Wandering and/or getting lost


Trouble concentrating
Trouble concentrating

Confusion and dizziness
Confusion, and/or dizziness

Restlessness
Restlessness

Cellular apathy
Cellular apathy

Changes in emotions
Changes in emotions

Memory loss
Memory loss


Increasingly inappropriate social behavior
Increasingly inappropriate social behavior

Lack of proper judgment
Lack of proper judgment

Repetitive compulsive disorders
Repetitive compulsive disorders

A decline in personal hygiene
A decline in personal hygiene

Loss of sensitivity towards others
Loss of sensitivity towards others

Depression
Depression


Depression
Depression

Rapidly worsening confusion
Rapidly worsening confusion

Disorientation
Disorientation

Difficulty in walking
Difficulty in walking

Muscle stiffness
Muscle stiffness

Double vision orhallucination
Double vision/hallucination


Confusion
Confusion

Lack of coordination in voluntary movements
Lack of coordination in voluntary movements

Severe memory loss
Severe memory loss

Visual changes
Visual changes

Disorders of the digestive tract
Disorders of the digestive tract

Disorientation
Disorientation

CAUSES OF MND
Motor Neuron Disease is an uncommon neurodegenerative condition, primarily affecting motor neurons involved in muscular movements. Studies have correlated different lifestyle-related, genetic as well as epigenetic factors to be responsible for its onset. Statistics have confirmed its prevalence in people in the age group of 60-70 years; however, a certain form of MND can affect humans of all age groups.

CAUSES OF
ALZHEIMERS
  • Certain viral infections may hijack connections between brain cells and muscles causing acute flaccid paralysis; such as poliovirus.
  • Long term exposure to certain chemicals and/or toxins
  • Genetic predisposition
  • The inflammatory response triggered due to a faulty autoimmune mechanism
  • Lack of secretion of neurogenic growth factors, degeneration, aging of motor neurons
  • Brain hypoxia, ischemia, stroke, unusual mental and/or physical stress, repeated head injuries
  • Other triggers include certain types of cancer and environmental contaminants
SUPPORTIVE THERAPY

“Motor Neuron Disease, a group of neurodegenerative disorders is incurable with conventional medicine; but certainly manageable with the help of regenerative medicine.”

Certain rehabilitative approaches are suggested along with stem cells to stimulate muscle power, reduce disease progression and help patients perform their day-to-day tasks independently for a prolonged period.

Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy

Acupuncture
Acupuncture

Hydrotherapy
Hydrotherapy

Sensory-Motor training
Sensory-Motor training
Cognitive Stimulation
Cognitive Stimulation

Lifestyle Disorders
Lifestyle Disorders

OUTCOMES

The field of stem cell therapy has witnessed improvements in neurodegenerative disorders like
Alzheimer’s, through many clinical investigations. However, it is important to note that scientists are still working on small issues to pave the way for the effective treatment of AD and accelerate the pace of development. With this ongoing advancement worldwide, we are proposing a reversal, multimodal treatment objectives for the symptomatic management of AD.

Worldwide Clinical Studies using Stem Cells obtained from different sources

Improvement in clinical signs and symptoms
ALS TESTIMONIAL

With the help of our comprehensive environment and advanced technologies, we believe in building trust and transparency with our patients. So far, we have provided stem cell therapy for ALZHEIMER’S DISEASE to a number of patients and their clinical improvements have been amazing. Check out some of our patient testimonials:

Must Read Articles on Stem Cell Therapy for Alzheimer

Alzheimer’s Disease: Causes, Symptoms, Diagnosis, Treatment
Alzheimer’s Disease: Causes, Symptoms, Diagnosis, Treatment

An aggravating type of dementia is Alzheimer's disease. For illnesses that adversely impact memory, thinking, and behaviour, dementia is a general word. Daily life is hampered by the changes. Many different conditions, including diseases and brain traumas, can lead to...

Relationship Between Thyroid Disorder And Dementia
Relationship Between Thyroid Disorder And Dementia

Dementia is a neurological disorder that has lately become increasingly common among the elderly. Memory and cognition deteriorate and inevitably become impaired in this neurological disorder. Did you know thyroid hormones are one of the factors that can be...

Meta-analysis of Alzheimer’s using stem cell therapy

So far, multiple clinical investigations examining the possible therapeutic benefits of stem cells along with their exosomes have been documented. The current ongoing clinical trial using umbilical cord blood-derived mesenchymal stem cells is an open-label phase I trial (NCT01297218) that resulted in no serious adverse events and no dose-limiting toxicity. The other investigation (NCT02054208) reported that the stereotactic administration of stem cells directly into the hippocampus and praecuneus was feasible, safe, and well-tolerated. The other phase I/IIa clinical trial (NCT03172117) confirmed delayed cognitive decline of the subjects than typical AD progression. However, due to the small sample size, and lack of a control group, no safe conclusion could be reached on efficacy.

FAQs

 
Advancells is a strong advocate of greater transparency in medical procedures in general and Stem Cells Procedures in particular. As a part of our effort of bringing transparent procedures to our clients, we provide each client a Third Party Certificate (from an internationally accredited lab) for the cell count and viability of the cells that we are able to process from the autologous cell source of the patient. To view the sample copy of the certificate  click here

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