Choose the Optimal Stem Cells

HOW TO CHOOSE RIGHT STEM CELL?

Select the ideal stem cells based on:

Disease or disorder

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Choose The Right Cells

The right kind of stem cells can affect the outcomes of the treatment. Therefore, choosing the right type of stem cell is essential. Stem cells vary in their type and sources with each cell offering unique advantages but also demonstrating limitations. The selection of the appropriate cell type depends on the disorder to be treated, the availability of cells, and the treatment goals. Understanding the minor differences between the stem cell types can help in strategizing a treatment tailored to the patient’s needs.

Types of Stem Cells

There are different types of stem cells, each with distinct properties and potential applications. Adult stem cells, derived from adult tissues, are also known as somatic or tissue-specific stem cells. They play a vital role in tissue maintenance and repair. Examples of adult stem cells include hematopoietic stem cells found in bone marrow and mesenchymal stem cells (MSCs). Embryonic stem cells (ESCs) are extracted from embryos and have high regenerative potential. Induced pluripotent stem cells (iPSCs) are generated by reprogramming adult cells back into a pluripotent state, resembling ESCs in their ability to differentiate into different cell types. They offer a potential alternative to ESCs while avoiding ethical concerns associated with embryo usage. Here is a brief comparison between the three stem cell types:

Feature	iPSCs (Induced Pluripotent Stem Cells)	ESCs (Embryonic Stem Cells)	Adult Stem Cells
Source	Adult tissue cells (e.g., skin or blood), reprogrammed to a stem cell	Inner cell mass of a blastocyst (early-stage embryo)	Adult tissues (e.g., bone marrow, adipose tissue, umbilical cord)
Pluripotency	Yes – Can become almost any cell type	Yes – Can become all cell types in the body	No – Multipotent (limited to certain lineages)
Ethical Concerns	Minimal	High	Minimal
Risk of Tumor Formation	High	High	Low to Negligible
Risk of Immune Rejection	Low to Moderate	Low to Moderate	Moderate to High
Ease of Use in Therapy	Cannot be used in therapy due to: – Absence of clinical-grade iPSCs – High risk of tumor formation	Cannot be used in therapy due to: – Ethical implications – High risk of tumor formation	Widely used in clinical trials and therapies
Current Clinical Applications	Mostly in research and preclinical trials	Mainly research and experimental use	Used in many clinical trials (e.g., orthopedic, autoimmune, cardiovascular)

Mesenchymal Stem Cells (MSCs)

Adult stem cells are employed in clinical settings. Examples include hematopoietic stem cells and mesenchymal stem cells (MSCs). MSCs have found due to the following properties:

Regeneration: Stem cells can differentiate into specialized tissue cells, replacing those that have been lost or damaged due to disease or injury.
Healing: They activate the body’s natural repair mechanisms, accelerating tissue recovery.
Anti-inflammatory Action: Stem cells help reduce chronic inflammation—a major factor in many degenerative conditions.
Antioxidant Effect: They reduce oxidative stress, which contributes to cellular aging and damage.
Immune Modulation: Stem cells help regulate the immune system, promoting a balanced response that supports tissue healing.

Sources of Stem Cells

Three sources of MSCs have gained popularity in the clinical applications of regenerative medicine: bone marrow, adipose tissue, and umbilical cord.

Feature	Bone Marrow	Adipose Tissue	Umbilical Cord
Tissue Availability	Moderate	High	Readily Available
Invasiveness of the Extraction Procedure	High	Moderate	Non-invasive
MSC Yield	Minimal	High	High
Regeneration Potential	Moderate	Moderate	High
Immune Modulation Property	Strong	Moderate	Very Strong

Understanding the different types and sources of stem cells is crucial for harnessing their regenerative potential and advancing therapeutic applications in various fields of medicine.

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Advancells is a strong advocate of greater transparency in medical procedures in general and Stem Cells Procedures in particular. We do not have any medical doctors on our payroll and we do not give any medical opinion or conduct medical procedures at our premises. We are a CGMP compliant cell manufacturing facility and provide each client a Third Party Certificate (from an internationally accredited lab) for the cell count and viability of our cells. View sample Certificate