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Stem cell therapy for Orthopaedics

Stem Cell Treatment For Orthopaedic Disorders

Orthopaedics is the branch of medical science, concerned with the conditions involving the musculoskeletal systems. This complex system includes our bones, ligaments, tendons, muscles and nerves. All these tissues work with the great synchronization to allow us to move, work and be active. This branch involves caring for patients with all age groups, right from newborn with club feet to young athletes requiring arthroscopic surgeries to older people with arthritis.

Some of the commonly associated problems within this branch of medical sciences are:

  • Osteoarthritis
  • Fibromyalgia
  • Osteomalacia
  • Osteopenia
  • Osteoporosis
  • Rheumatoid Arthritis
  • Systemic Lupus Erthromatosus Treatment
Stem cell therapy for osteoarthritis

Out of all the forms of arthritis, osteoarthritis is the most common form of it affecting millions of people worldwide. It is the chronic condition, occurring due to degeneration of protective cartilages, which are cushioning our joint and bones. Due to this degeneration, bones or joints are directly exposed for rubbing to each other. Due to excessive rubbing, joints are damaged, become stiff, painful and eventually associated with the loss of movements. It has been observed that although all joints in our body are at a risk of OA, however, joints of hands, knees, hips, and spine are at a greater risk. Osteoarthritis often gradually worsen as conventionally no cure exist for complete reversal of damage, although some lifestyle changes such as maintaining a balance diet, healthy weight, physical activity can promote the slow progression of the disorder.

Signs & symptoms of OA can include

  • Joint Pain
  • Joint Tenderness
  • Stiffness
  • Loss of Flexibility
  • Grating sensation
  • Bone Spurs
Stem cell therapy for fibromyalgia

Fibromyalgia is the third most common musculoskeletal issue, after osteoarthritis and rheumatoid arthritis. Although, the condition is commonly misinterpreted to be arthritis related condition, due to swollen and painful joints; in reality, fibromyalgia does not cause any severe damage to joints or other tissues. However, it is related with arthritis due to severe muscular pain, tiredness and unexplained fatigue that can have significant negative impact on a day to day schedule.

One of the hallmarks of fibromyalgia is muscular pain, typically accompanied with set of symptoms, listed herewith:

  • Fatigue
  • Insomnia
  • Anxiety and/or depression
  • Abdominal pain
  • Chronic Headache
  • Dryness in mouth, nose and eyes
  • Hypersensitivity to cold
  • Stiffness
  • Numbness and tingling sensation in the fingers and feet

Moreover, expression of some tender points in specific locations, have been documented to be the unique aspects of the condition that are painful on pressure applications.

Although, many theories have been put forth to pinpoint the cause of fibromyalgia; but scientific evidences have yet to pinpoint the exact cause. However, a generalized belief can suggest disruption in the signaling pathways of neurons due to hormonal imbalances, causing muscular pain. Moreover, statistics suggest that women between the age group of 25-60 come under the high-risk category and are ten times more likely to be affected with the condition than men; thus, linking it with the genetic predisposition.

Apparently, experts agree that fibromyalgia may be a resultant of combination of factors, rather than a single cause.

Stem cell therapy for Osteomalacia

Osteomalacia is the milder form of bone disorder, often associated with softer bone tissue mostly due to vitamin D deficiency. It is a kind of physical deformity which can be linked up directly with the softer bones. Soft bones are more likely to bend or bow or fracture as compared to healthy bones.

However, it is an important factor that Osteomalacia and Osteoporosis or Osteopenia are very different from each other as Osteoporosis or Osteopenia is the weakening or loss of previously constructed bones but Osteomalacia is the defect in the bone building process itself. For that matter, there is no age limit to this particular deformity. It can also happen in childhood, which is commonly known as Rickets.

Human bones are constantly formed through a process known as Bone Remodelling. Older bones are destroyed from the body through the process known as Bone Resorption. Through this process osteoclasts are used to break down the bone and release minerals and calcium from the bones into the blood. It is observed that this bone resorption is more in Osteomalacia due to some medical conditions such as hyperthyroidism or hypocalcemia etc. The two very important causes of the condition are found to be

  • Insufficient calcium absorption from the intestine because of lack of dietary calcium
  • Phosphate deficiency caused by increasing loss of phosphates or other minerals through urine.

Some of the common indications of the disease can be

  • Pain is linking up with major bones, such as spinal bone, hip bones, femur bones of the leg.
  • Muscle weakness or vertebrae compression
  • Hypocalcaemia
  • Pelvic flattening
  • Easy fracturing
  • Bending of bones
Stem cell therapy for Osteopenia

Osteopenia refers to the early signs and symptoms of weak bones and bone loss which can be linked up to Osteoporosis in the later phase. In another words, a person's bone desinty when checked in Osteopenia, it can be lower than normal, however not low enough to be considered as osteoporosis.

It is also not necessary, that everyone who have osteopenia will be affected with osteoporosis in later stage.With the adaption of healthy life style changes, one can definitely prevent further loss of bones. This can be eating healthy diet high in calcium and fibre, doing regular weight bearing exercises, complete stoppage of smoking and caffeign intake. Any body can be a pray to this disease but some of the possible risk factors, compiled from the available data can be

  • Being Female
  • Having small body stature or being thin
  • Getting too little calcium in diet or diet is full of caffeine
  • Intake of too much carbonated drink
  • Smoking
  • A family history of osteoporosis or osteopenia
  • Heavy alcohol consumption
  • Early menause
Stem cell therapy for Osteoporosis

Osteoporosis is the serious bone disorder, happening when there is too much of the bone loss due to soft brittle tissue or there is a little or half formation of bones that are required by the body. Due to excessive brittleness in the bone, bone becomes too weak or it may break due to minor fall. The condition is progressive to the extent that these bones may get affected even from simple actions like sneezing or bumping into the furniture.

The complications associated with osteoporosis can be severe pain and life time deformity. Sometimes it can also be associated with the change in the body posture or complete loss of movement if unattended for a longer period of time. The healthcare professionals directly link up the disease with porous bones, which results in an increased loss of bone mass and strength.

Post Menopausal Osteoporosis

The relationship between the lack of some hormones in the premenopause and menopause have been recently figured out. Usually women after the age of 40 or more experience unnecessary pain, fatigue or low bone density due to major turbulence in estrogen and progesterone level. It is been observed that until the age 30 or latest by 35, a human body is in constant state of bone renewal to compensate for the lost bones. The process of bone renewal is scientifically known as Bone Remodelling. However beyond 40, when women are in their post menopausal phase, this bone renewal is slowed to the extent that the bone resorption is more than it; resulting in a gradual bone decrease in the bone mass. Once this loss of bone reaches certain point, a women is believed to have osteoporosis.

It has been observed that women are at the high risk of developing osteoporosis, as high as four times than men, due to their body structure associated with lighter or thinner bones. Signs & symptoms include:

  • Joint Pain
  • Joint Tenderness
  • Stiffness
  • Loss of Flexibility
  • Grating sensation
  • Bone Spurs
Stem cell therapy for Rheumatoid Arthritis

Rheumatoid Arthritis is a kind of an autoimmune disorder, affecting joints and other areas of the body, causing them to be chronically inflamed. The negligence to it for longer period may lead to deformed and painful joints which are severely malfunctioned. With the passage of time, the disease can also affects other organs such as heart apart from joints.

Although the root cause of the disorder is still unknown, it is known to be inherited i.e. genetically modified disorder, principally involving synovial joints, eventually spreading to the whole body. From a compiled data of research and clinical trials, it has been evident that the disorder is no longer related in any way with the physical or emotional stress of the individual but very well linked with the possibility of genetic alterations in the immune responses. It has been observed that people who have inherited PTPN22 genes from the family background are in the high risk zones.

Apart from genetic, other environmental factors are also found to be associated with the appearance of the disease such as excessive smoking, moderate alcohol consumption or infection with the herpes virus such as Epstein Barr Virus & Human Herpes Virus 6. Vitamin D deficiency is also found to be more common with the people with RA than a generalised population.

In a simpler language, our body expresses two major antibody complexes associated with Rh factor and citrullinated peptides which are being attacked by the T & B lymphocytes, the white cells of our own immune system. This attacking seems to play an important role in the intense inflammatory response present in RA. This again contributes to inflammation of synovium in terms of edema, vasodilation.

Thus considering these facts, some of the commonly associated indications are as follows:

  • Rheumatoid Arthritis resistant to standard treatments
  • Ineffective anti-inflammatory drug therapy including steroids
  • Marked decrease in functional capacity of joints
  • Tropic disturbances of the musculoskeletal system
  • Considerable deviations of immunologic and hematopoietic matters

Arthritis is a complex family of musculoskeletal disorder comprising of more than 100 different conditions that destroy joints, bones, muscles, cartilages and other connective tissues. These in turn cause physical deformities or hamper physical movement.

Lupus is known autoimmune disorder of our immune system. Our immune system runs in a synchronisation of various antibodies and antigens to look after different viruses and bacteria, the body is exposing on a daily basis. These antibodies have a unique ability to recognize self antigens and non self antigens to initiate a proper immune response. But due to genetic modifications, at some point of time our immune system fails to recognize body's internal receptors as our own and attacks them. This event has a serious complications leading to the destruction of our own tissue. This error in the body's immune system is known as "Autoimmune Disorder"

Lupus is a thus an another kind of auto immune disorder altering the immune system of young people and ultimately resulting into swollen joints, red skins, hair loss etc. Although the symptoms associated with the diseases are painful, they do not pose any harm till the time the disease is not spread to the internal critical organs such as heart, brain etc. Thus it is always advisable to counsel the doctor immediately if you come across any of the following indications:

  • A persistent rash across the cheeks and nose in the generalised shape of the butterfly
  • Sun exposed sores, joint pain, fatigue
  • Mouth ulcers on the roof of the mouth
  • Lupus related ulcer appearing on the inner lining of the nose
  • Red, warm, swollen & tender joints
  • Inflammation on the inner lining of the vital tissues such as heart or lungs
  • Observation of microscopic blood cells or proteins that are generally absent in the urine
  • Anxiety, seizures or psychosis

As such there is no cure conventionally for treating Arthritis; besides medications that are there to help relieve the pain temporarily. Anti inflammatory drugs or steroidal medicines are commonly prescribed for all orthopaedic conditions, however it is important to note down that the long term exposure of these medicines can pose other health related complications. In this regard, medical professionals as well as people suffering, were desperately in need of an alternative treatment option, that will help them get out of this trauma.

Stem cells treatment is like a miracle for patients that can help alleviate the pain and inflammation in joints. Stem cells are very naive cells of the body, which can be differentiated to any kind of cells of any kind of origin. This remarkable ability of them has been exploited by the healthcare system to promote regeneration of different damaged tissues, which is the basis of many diseases.

List of diseases treated

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Stem Cell Treatment

How does stem cell therapy work?

Adult stem cells can be recovered from our own body tissues, like Bone Marrow or Adipose Tissue/Fat, which can be recovered in larger quantities and are allowed to differentiate inside the body (In Vivo). In fact, adult forms of these stem cells are being stored in all mature organs and are poised to leap into the action to repair damage, which has occurred from day to day wear and tear of the body. However, as we age or have bigger issues as mentioned here with our body may not be able to recruit enough number of these biological adjutants to the desired location, to fully repair the area.

Advancells helps overcoming this problem by extracting stem cells from Bone Marrow and/or Belly Fat, an area with high stem cell numbers, then concentrating these mighty cells in the controlled environment and reinjecting into the damaged area, to allow natural regeneration of damaged body parts.

Bone Marrow derived Adult Stem Cells and Super concentrated Platelet Rich Plasma Procedures

Bone Marrow derived adult stem cells in combination with growth factors provided by concentrated PRP gives the best results in cases of various orthopaedic issues. We have specialized our treatment protocol with stimulation technique; wherein we trigger your stem cells, with rich concentrate of growth factors, extracted from autologous blood. These laser activated stem cells, when infused into patient’s body, can immediately start signaling. These signals are being identified by the immune cells, which attract stem cells to the targeted areas.

Our advanced technology is enriched with more activated cells and a new improved version of traditional platelet rich plasma, with a whooping 90% success rate in all orthopedic conditions.

We understand the science behind stem cell therapy and hence try to offer a very comprehensive treatment protocol, with maximum recovery.

Our procedure can be divided into

Step 1- Qualification For The Treatment

Pre-Treatment Assessments

Pre-Operative Procedure

As per these results, the patient will be counseled further for final decision of protocol.

Step 2- Source Extraction

On the basis of consultation and requirement, a source of stem cells will be decided. On a generalized note patient will be prescribed autologous extraction of body’s own stem cells; however, in certain conditions, the procedure can be little diverted from its path, for a better outcome.

Sample extraction can be done from the patient, on the specified date and time; with the application of local anesthesia. The entire procedure takes around 7-8 hours; however, in case of certain conditions like patient has to be with us for little longer period of time.

If you are still curious to know more about the procedure, kindly refer our detailed snapshot below:

Stem cell therapy procedure for Orthopaedic

Step 3- Laboratory Processing

The extracted sample will be dispatched to our regulatory compliant, cGMP authorized laboratory for processing. Advancells processing facility is a state of the art, class 10,000 clean room, equipped with all automated technology. Stem cells will be isolated from the source, processed further and revitalized with patient’s own plasma and laser stimulation for the quick repair and natural recovery.

Stem cells will be concentrated in injectable volumes, with minimum manipulation and will be characterized for their quality, purity and viability. For us, every client is precious and would like to maintain complete transparency between two of us, which is why we are providing third party certificate of quality, along with our Certificate of Analysis.

Step 4- Stem Cell Implantation

The enriched fraction of stem cells will be infused directly into the patient’s body through one of the modes of implantations, mentioned below.

Targeted Delivery: - Cells will be delivered directly at the site of injury; i.e. between the joints in case of knees, using guided imaging technology.


Orthopaedic Stem Cell Treatment Results

Ten patients mean age ≥ 45 years (Sex ratio; 2 male: 3 female) with chronic knee pain unresponsive to conservative treatments and radiologic evidence of degenerative arthritis were treated with autologous bone marrow stem cells by intra-articular injection (Read more...)

Patient's Stories

Ms. AS 33 Years Old Fibromyalgia

"It has almost been two months now, since I have undergone stem cells therapy; and I am having almsot 80% relief from pain, head ache and better quality of life."

Owen Cooke, 61 years, Osteoarthritis and Foot Damage

"Overall, I am very, very pleased with the result so far."

Malcolm Pasley, Osteoarthritis (Knee)

"I notice a huge improvement in both knees."

Robert Da Prato, 64 years, Osteoarthritis - Knees

"I am happy. Perhaps in a few more months, my situation will improve."

Wendy Funston, 57 years, Arthritis in Hands, Knees, Feet, Elbows

"Since treatment I HAVE BEEN PAIN FREE!!!!"


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Frequently Asked Questions

  • What is orthopaedics?
  • Orthopaedics the branch of science, focusing on injuries and diseases of the body's musculoskeletal system; including bones and muscles.
  • What is joint replacement surgery & how long it last?
  • Joint replacement surgery is performed to replace damaged joint with a new, artificial joint known as a Prosthesis. On an average, these joints have a lifespan of 10 years, however it varies depending upon the usage and person's age.
  • What is the difference between the sprain or strain?
  • A strain occurs when the muscle or tendon is stretched or torn. A sprain occurs when a ligament is stretched or torn.
  • What is Sciatica?
  • In our lower back, nerves join to form the Sciatic Nerve; which runs down in the leg and controls the muscles of the leg. Sciatica is the condition that may cause a radiatic pain, numbness, tingling and/or muscle weakness in the leg.
  • What is shoulder impingement?
  • Impingement syndrome, is a common disorder of the shoulder referring to an improper alignment of the bone and the tissues in the upper arm. Inflammatory conditions such as arthritis are closely related to the impingement syndrome.
  • What is the separated shoulder?
  • A shoulder separation occurs when the outer end of the collarbone separates from the end of the shoulder blades because of the torn ligaments. The injury occurs most often from a blow to the shoulders or stretched hand or arms.
  • Do men get osteoporosis?
  • Although osteoporosis is more common in women, atleast one in eight over 50 have the chances of getting osteoporosis. As with the declined testosterone levels in men can also lead to increased chances of the bone loss.
  • How can Osteoporosis be prevented?
  • Osteoporosis can be prevented by reaching the peak bone mass, during the childhood and teenage years. Few habits can be incorporated in order to increase bone mass such as enough calcium and vitamin D uptake by drinking milk and milk products, regular exercise, avoiding milk and milk products, avoiding smoking and excessive alcohol consumption.
  • Can stem cell treatment, reverse my damage?
  • Yes, stem cells are the pristine cells of the body, which can give rise to many different types of cells upon proper signalling. These cells have been exploited successfully to differentiate into neurogenic, osteogenic and chondrogenic lineages. They have been isolated from the very own potent sources of our body known as Bone Marrow and Adipose Tissues. They can be minimally manipulated and implanted back into the body to promote neuroregeneration, bone reconstruction, reformation of tendons and cartilages.
  • Where can I get more information about Disease?
  • Please go through, our treatment brochures for other Orthopaedics related information.

What can you expect?

Many patients after stem cell treatment reported to be exhibiting:

  • Inflammatory process activity decreases
  • Morning stiffness, joint tenderness, oedema is diminished
  • Patient's functional capacity has been improved tremendously
  • Considerable redevelopment of cartilaginous tissue observed from X-Ray analysis that can avoid further damage to the joints.
  • In most of the cases, complete discontinuation or considerable reduction of anti inflammatory drugs has been achieved.
  • Quality of life has been improved in patients achieving 100% target.
  • However, a complete restoration of the central nervous system, is the prolonged process and requires lots of patience and repetition of treatment if required or suggested.