Stem Cell Therapy for Cerebral Palsy



Cerebral Palsy

Cerebral palsy is a broad term used to describe a group of non progressive "chronic palsies" impairing control over movements due to brain damage. Children with CP are most likely born with the condition, but some may acquire later during a first 3-5 years of child's life. The disorder is generally associated with the secondary conditions such as difficulty eating, bladder/bowel problems, seizures and learning disabilities; which can get better or worse over time.

CP is often associated with abnormal brain development or damage to some parts of the brain may be due to poor oxygen supply or internal bleeding. Though it is difficult to pinpoint exact cause, the primary Cerebral palsy causes may be genetic abnormalities, congenital brain malformation, maternal infections or fever etc. This damage to brain cannot be reversed with the current treatments available. For the children with CP who struggling for the normal life style; stem cells technology has come up as the new ray of hope. Apart from tendency to give rise to healthy neurons; these stem cells also has a unique ability to identify and home in the affected area. These cells are also responsible for creation of microenvironment and secretion of hormones for faster rejuvenation.

We all should understand that stem cell treatment is not a temporary solution but a long term goal; through which it is possible to live in a better way.


Major Manifestations of Cerebral Palsy, in patients include the following:

Signs of cerebral palsy include:

  • Not blinking at loud noises by one month
  • Not sitting by seven months
  • Not turning head toward sounds by four months
  • Not verbalizing words by 12 months
  • Walking with an abnormal gait
  • Seizures

Symptoms of cerebral palsy include:

  • Choking,Difficulty grasping objects, Difficulty swallowing
  • Fatigue, Inability to focus on objects, Inability to hear, Pain

Conventionally only supportive treatments were present to temporarily relieve the pain or the symptoms, additionally there are many support services available for the effective management of some activities and programs such as day care services or nursing programs. Although the damage in terms of death of neurons cannot be halted or reversed with this treatment approach till the discovery of stem cells.

Stem cells are the master cells of the body, mainly differentiating into the required type of cells upon administering a proper cocktail of growth factors and stimulatory agents in vitro. The stem cell therapy approach mainly focuses on delivering the sufficient number of Adult Autologous Stem Cells which will travel into multiple areas of the brain where the damage has occurred.These transplanted stem cells are potential to transform into new brain cells which are needed for the replacement of damaged cells. They also help in creating a microenvironment that will secret some of the enzymes required for making connections to replace lost parts of the complex network.

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Stem Cell Treatment

Stem Cell Treatment For Cerebral Palsy: Advancells Protocol

At Advancells, we have been providing assistance to many children for coping up with the problems and to find out permanent solution. We are exploiting the most potent Stem Cells isolated from patients own Bone Marrow or Adipose tissue or may be both depending upon the assessment. Our top priority is to provide very comprehensive, individualized treatment pattern which is best suited for the patients undergoing treatment.

Our aim here in Advancells is to help the child to achieve as much independence as possible throughout his/her life.

Step 1- Qualification For The Treatment

A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pretreatment assessments can be suggested depending upon the patient's medical and family background:

Pre-Treatment Assessments

  • Routine Blood Tests
  • Routine Urine Analysis
  • Infectious disease testing
  • Physical Examination
  • X Ray

Pre-Operative Assessments

  • MRI
  • CT Scan
  • Neurophysiology
  • Medical Neurological Reports
  • Medical History
  • Counselling

As per these results, the patient will be counseled further for final decision of protocol.

Step 2- Source Extraction

With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolated from Bone Marrow or Adipose Tissue, as these are the most potent autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cells stimulation therapy for some, depending upon the severity and requirement.

The specified amount of samples will be extracted from the patient's own body on the intimated date and time, with the application of local anesthesia. The entire procedure takes around 7-8 hrs, however, in case of extraction from both the sources the patient has to be with us for a little longer time.

If you are curious to know more about the procedure, kindly refer our detailed snapshot below:

stem cell treatment for ALS

Step 3- Laboratory Processing

The extracted sample, will be sent to the government approved cGMP laboratory for processing. The sample processing will be done in a state of the art class 10,000 clean room in compliance with the ISO and GMP standards.

The sample will undergo minimum manipulation in our complete automated Sepax technology to be enriched with the pure population of stem cell culture. The isolated stem cells will be characterized for quality, purity and viability.

The client will be given a third party certificate from Internationally Accredited Lab for the quality purpose.

Step 4- Stem Cell Implantation

Once stem cells are enriched and ready to be injected back into the body, we have worked on different modes of implanting them. However, depending upon the patient's physiological and mental well being, one of the following will be finalized by our experts.

  • Intravenous Injection:- Stem cells will be infused into the body, by infusing through the vein.
  • Intra-thecal Injection:- Stem cells will be infused, into the cerebro-spinal fluid into the spinal canal. This route is most popularly known as Lumbar Puncture

Follow up Treatment

In a post treatment care, the patient will be asked to visit the doctors after a specific period of time, for some rehabilitation programs, including Behavioural and emotional development, Communication and social Interaction, Self regulation, Cognitive & Adaptive skills.



Cerebral Palsy Stem Cell Treatment Results

Majority of the children treated with us have shown marked improvement in overall control and coordination of the body, improved social and intellectual behavioural pattern. They have observed to achieve emotional stability.

A total of 116 patients suffering from cerebral palsy went under treatment and were evaluated post-treatment. We observed clinical improvements in 66.4% of the patients undergone Cerebral Palsy Treatment.(Read more...)

Patient's Stories

Martin Marinov, Cerebral Palsy Patient Treatment Story

Jona Ghelli, 16 years old, Cerebral Palsy and Microcephaly

"We're definitely going to be going back again."

Harrison Spiers and Dominic King, Cerebral Palsy

"...Life is easier for him now..."



Martin Marinov, CP Patient & 5 Month Follow Up Video, Bulgaria.
Martin Marinov, CP Patient & 5 Month Follow Up Video, Bulgaria.
Martin Marinov, CP Patient video, Bulgaroa, 2016
Martin Marinov, CP Patient video, Bulgaria
Soumalya Sarkar, Cerebral palsy Patient Video, India
Soumalya Sarkar, Cerebral palsy Patient Video, India
Ethan Radtke, Cerebral Palsy Patient video
Ethan Radtke, Cerebral Palsy Patient video
More Video


Frequently Asked Questions

  • Is cerebral palsy a disease?
  • The term cerebral palsy refers a disorder based in the brain which affects movement. Cerebral refers to the brain, while palsy refers to the interference with movement. The movement difficulties experienced by cerebral palsy patients are due to damage or malformations within in the brain, not by problems in the muscles themselves.
  • Are there different types of cerebral palsy?
  • There are several different types of cerebral palsy: spastic diplegia, spastic hemiplegia, spastic quadriplegia, athetoid dyskinetic cerebral palsy, choreoathetoid dyskinetic cerebral palsy, dystonic dyskinetic cerebral palsy, ataxic cerebral palsy, hypotonic cerebral palsy, and mixed cerebral palsy.
    The spastic forms of CP are characterized by stiff muscles and muscle spasms. The dyskinetic forms of CP are characterized by involuntary, writhing movements. Ataxic CP, the least disabling of all the forms, is characterized by balance and depth perception problems which make walking difficult. Hypotonic CP is characterized by overly relaxed, "floppy" muscles. As the name implies, mixed CP is characterized by symptoms of two or more forms of the disorder.
  • How severely will my child be affected by cerebral palsy?
  • The answer depends on the type of CP and the extent of the brain damage or brain malformation which caused it. Impairment from CP ranges from mild to severe. Many people with cerebral palsy lead nearly normal lives, while some CP patients require constant care from others throughout their lives.
  • What causes cerebral palsy?
  • Cerebral palsy is caused by brain damage or brain malformations. Occasionally genetic abnormalities cause the brain to develop abnormally, but most cases of brain malformation are due to other factors.Exposure to toxins can interfere with the proper development of the unborn baby's brain. Damage to the white matter of the brain is particularly likely to lead to CP. Between 26 and 34 weeks gestation, the unborn baby's brain is especially vulnerable to injury to the white matter, but damage can occur at any point in the pregnancy.
    Infections in the mother or in the unborn baby can lead to brain damage. The inflammation produced as a normal part of the infection fighting process can cause damage to the baby's developing brain cells. Infections can also trigger strokes in the fetus, leading to oxygen deprivation; prolonged oxygen deprivation can cause brain damage which leads to CP.
    Uncontrolled high blood pressure in the mother during pregnancy puts the fetus at higher risk for a stroke. Extremely low maternal blood pressure can also put the unborn baby at risk for a stroke. Monitoring and controlling the blood pressure is a vital part of good prenatal care.
    Rh incompatibility, a condition in which the fetus' Rh blood type conflicts with the mother's Rh blood type, can also cause cerebral palsy. Rh incompatibility leads to severe jaundice a buildup of bilirubin in the blood which can cause deafness and CP. a Fortunately, Rh incompatibility can be treated if caught in time. In the United States, testing for Rh incompatibility is regular part of prenatal care, but this is not the situation in many other countries. If you are pregnant, make sure your doctor checks for Rh incompatibility as early as possible in the pregnancy.
    Severe jaundice caused by problems other than Rh incompatibility can also lead to CP. Jaundice is common in newborns, but it can be treated.
  • Is cerebral palsy hereditary?
  • Some cases of brain malformation are due to gene abnormalities which prevent the brain from developing normally, but this is rare. Most cases of CP are not in anyway hereditary, but are due to factors which occurred during the course of the pregnancy.
  • What is congenital CP?
  • The term congenital means present at birth. Between 90 to 95 percent of CP cases are congenital. Congenital CP includes those cases which were caused by oxygen deprivation during birth. Doctors used to believe that most cases of CP were caused by a lack of oxygen during a difficult labor and delivery, but it is now known that fewer than 10 percent of congenital cerebral palsy cases stem from asphyxia or other problems during birth. The majority of problems that cause CP occur during development in the womb. Brain trauma, infections, strokes, and other problems after birth can occasionally cause acquired CP. As the name implies, acquired CP means that the condition was acquired after birth.
  • Can alcohol consumption during pregnancy cause cerebral palsy?
  • Alcohol consumption during pregnancy raises the risk of complications which can cause cerebral palsy, and many other birth defects. There is no established safe-level of alcohol consumption during pregnancy, so pregnant women should avoid alcohol entirely.
  • Are premature babies at greater risk for cerebral palsy?
  • Babies born prematurely are at a higher risk for cerebral palsy. Modern medical techniques save a higher percentage of premature babies, but these babies are more prone to developing disabilities than full term babies are. Babies with a low birthweight are also more at risk for cerebral palsy, even if they are full-term.
  • Are women with certain medical conditions more likely to have a baby with CP?
  • Women with mental retardation, a seizure disorder, or a thyroid disorder are slightly more likely to have a baby with CP, than women who do not have these conditions.
  • What percentage of cerebral palsy patients have mental retardation?
  • According to the National Institute of Neurological Disorders and Stroke, approximately two-thirds of patients with CP have some mental impairment. Mental retardation can range from mild to severe. People with the spastic quadriplegia are more likely to have mental disabilities than those with other forms of CP. CP patients with epilepsy are also more likely to have mental retardation. Because of communication difficulties it is sometimes difficult to accurately assess the IQs of CP patients. Learning disabilities without mental retardation are also associated with cerebral palsy. The speech, hearing, and vision problems which sometimes accompany CP can make learning difficult. Many CP patients have normal IQs and no learning disabilities. A few CP patients are intellectually gifted.
  • Is cerebral palsy a life-threatening condition?
  • Cerebral palsy is not a terminal condition, but before the advent of newer medical techniques in the mid-twentieth century most children with CP did not live into adulthood; complications from the disorder claimed their lives. Today, between 65 and 90 percent of children with cerebral palsy reach adulthood. CP is stressful for the entire body and can cause premature aging, particularly of the heart, blood vessels, muscles, joints, and bones. The complications stemming from CP can be life-threatening. Cerebral palsy can lead to respiratory and swallowing difficulties. Difficulty swallowing can lead to malnutrition and/or aspiration pneumonia in which food is inhaled into the lungs causing an infection. Malnutrition causes weakness and muscle deterioration; it weakens the immune system making the patient more vulnerable to infections and less able to fully recover if an infection occurs. CP patients whose mobility is extremely restricted may have to sit or lay down for extended periods of time, running the risk of pressure sores. Untreated pressure sores can develop life-threatening infections. The bowel and bladder problems frequently associated with CP can lead to more serious complications when not properly managed.
  • Can cerebral palsy be cured?
  • Cerebral palsy cannot be cured. The brain damage or brain abnormalities from which it stems are irreversible. Fortunately, today much can be done to improve the quality of life for CP patients.
  • Can cerebral palsy be prevented?
  • Good prenatal care can help lower the risk of fetal strokes from maternal high blood pressure and infections. Appropriate prenatal care can also prevent complications from Rh incompatibility. Preventative measures before pregnancy can also reduce the risk of birth defects; women with inflammatory pelvic disease should have the condition treated before becoming pregnant. Women planning on becoming pregnant should vaccinated against Rubella (German measles), which can cause birth defects and should consult their doctor on other measures they can take to assure a trouble-free pregnancy and a healthy baby. However, some factors which can cause cerebral palsy and other birth defects cannot be prevented. There is no guarantee that the mother or the baby will not develop an infection; infections in the unborn baby are difficult to treat.
  • What type of research is being done on cerebral palsy treatments and prevention?
  • Extensive research is being done on cerebral palsy treatment and prevention. Much of this research is funded by the National Institute of Child Health and Human Development, the National Institute of Neurological Disorders and Stroke, and private organizations such as the United Cerebral Palsy Research and Educational Foundation. Research is being done on brain development in hopes of learning what can be done to prevent brain abnormalities from developing. Scientists are also studying the role uterine infections play in the development of CP. Other research centers on finding new ways to diagnosis CP earlier, so that treatment can be begun as quickly as possible; early treatment leads to better outcomes for CP patients. In addition, research is being conducted on the various methods of physical therapy used for CP to determine which methods are most effective and to develop better technology to utilize with these methods. For example, functional electrical stimulation of the muscles can help strengthen spastic muscles, but the technique uses bulky implanted devices; research is being done on using a hypodermic needle to inject small devices at the necessary sites, thus making this therapy more practical and affordable.
  • How can stem cells be beneficial to treat?
  • Undifferentiated adult autologous stem cells are mutable and can metamorph into countless number of cells as per the requirement. This remarkable propery of stem cells can be exploited for treating variety of diseases. These cells can be isolated from the most potent sources of our own body known as Adipose Tissue and Bone Marrow. Upon implanting back into the body, these cells can rapidly multiply with the great speed to restore damaged fibres, regenerate neuron as well can improve damaged function.
  • Why is stem cells treatment better than conventional treatment approach?
  • Conventional treatment approach highly invasive associated with many side effects. Although stem cells can naturally heal the body from damage and regenerate lost neurons to improve impaired functions. Additionally since body's own cells are used for repairing, the entire treatment is minimally invasive without any side effects.
  • Where can I get more information about Disease?
  • Please go through, our treatment brochures for other Cerebral Palsy related information.


What can you expect?

Many Cerebral Palsy patients after stem cell treatment reported to be exhibiting:

  • Self confidence and good control over day to day activity
  • Improved concentration
  • Improved self regulation
  • Better tolerability of daily chores
  • Improved quality of life
  • Complete stoppage or progression of the disease

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