Advancells Follicular Stem Cell Implantation (AFSCI): Stem cell treatment for Hair Loss

Are you also suffering from hair loss? Don’t worry, you are not the only one as millions of people including us suffer from what seems to be a common issue i.e. hair loss. 

A condition called alopecia or hair loss causes the person to lose a significant amount of hair. It can be either localized or diffused. Normally, a person loses 100 hair strands daily but if the hair loss is greater than 100 strands then it’s a worrying sign.

Advancells Follicular Stem Cell Implantation (AFSCI) edges out fancy stuff like shampoo, serums and oils and could change the way you think about the possibility of hair growth. AFSCI is transforming many lives by providing a solution for hair loss. And guess what this blog not only aims to provide solace but also sheds light on how AFSCI aids in hair restoration.

Factors that can trigger loss of hair

Many causes can trigger loss of hair. The following constitutes the causes of hair loss.

1. Infections: certain bacterial infections like cellulitis and fungal infections like tinea capitis on the scalp can lead to loss of hair.
2. Medications: drugs that can cause temporary or permanent loss of hair are chemotherapy drugs, steroids, therapy like hormone replacement therapy or either birth control pills.
3. Pregnancy: due to hormonal changes after the birth, women usually experience loss of hair.
4. Alopecia Areata: is an autoimmune condition which can cause hair loss or baldness either in patches or covers the entire head.
5. Conditions that lead to loss of hair are hypothyroidism and cancer, which can also cause hair thinning.
6. Genetics also play an important role in hair thinning as some people might automatically suffer from loss of hair due to heredity.
7. Hair loss is also commonly encountered in young adults because of the adaptation to modern lifestyle habits like diet, sleep, smoking and alcohol consumption, along with stress that majorly contributes to loss of hair. 
8. Therefore, lastly, stress is another cause that can lead to loss of hair.

AFSCI for loss of hair

AFSCI is thought to be successful because rather than just stimulating hair growth it focuses on rejuvenating hair follicles from their dormant state. Usually, the process of rejuvenation leads to development of new hair strands. Apart from this, it also reduces the thinning and thickens the existing hair.

Benefits following AFSCI for hair loss

Reduction in hair shedding, hair texture improvement, 70% follicle growth, revitalization of the scalp, reduction in patterns of baldness, hair growth visible inside 2-3 months and also prevention of signs of dandruff and greying are the benefits that one can reap after AFSCI.

Role of growth factors in growth of hair

1. The factor that enhances survival and proliferates hair follicles is Insulin like growth factor 1 (IGF-1).
2. Vascular endothelial growth factor (VEGF): Increases angiogenesis which increases hair follicles.
3. Hepatocyte growth factor (HGF): Increase follicular cells proliferation. 
4. Transforming growth factor-beta (TGF-β): Activates hair growth signaling pathway. 
5. Platelet-derived growth factor (PDGF): Stimulates and maintains growth phase of hair cycle. 
6. Interleukin 6 (IL-6): stimulate hair neogenesis by activating STAT-3.       

The above data constitutes the role of various growth factors in hair restoration.

Exosomes role in hair growth

In order to stimulate growth of hair, Exosomes release growth factors and cytokines which trigger the follicular activity. In addition, they also release IL-10 and TGF-β which aids in hair growth. Furthermore, exosomes also promote angiogenesis. Thus, the benefit is that it nourishes the follicles of the hair by improving blood supply.

Chemical activation of stem cells

When mesenchymal stem cells are implanted they require chemical activation to undergo differentiation into hair follicles. If the process of chemical activation does not take place then degeneration of follicles takes place and hair doesn’t grow. 

Researchers from California University were able to identify certain drugs that can aid in the process of chemical activation. The drug RCGD423 triggers the signaling pathway which increases the lactate production. The production of lactate stimulates the follicles and triggers growth of hair. On the other hand, the drug UK5099 directly increases the production of lactate which in turn stimulates hair growth.

The following section highlights the benefits of AFSCI

1. To begin with it is minimally invasive with limited side effects.
2. Next, availability of personalization according to need.
3. It is suitable for all hair types.
4. Effective across almost all stages of hair loss.
5. Lastly, long term effects post implantation.

Therefore, the above are some of the benefits of AFSCI 

Nutrients essential for hair growth

The nutrients that play an important role in hair growth and aid stem cell hair restoration are

1) Vitamins: Vitamins A, B, C, D, E, particularly biotin, niacin and folate to stimulate the follicles of hair, moisturize the hair and repair the damaged hair.

2) Fatty Acids: essential fatty acids i.e. omega 3 fatty acids provide nourishment to the hair follicles.

3) Minerals: minerals like iron, zinc and selenium to help in protein synthesis and provide strength.

4) Amino Acids: essential amino acids and proteins as it helps in formation of keratin.

The above nutrients are essential for hair growth.

Did you know?

According to a study present in the journal Cell, analysis revealed that intermittent fasting slows down the growth of hair. 

Studies on adults:

Similarly, the hair growth capacity decreased by 18% when the study was performed in adults who did intermittent fasting compared to those who were on regular diet. However, further studies are needed to determine full-fledged effects of intermittent fasting on hair growth.

Study on mice:

For the study two groups of mice were shaved, on one group intermittent fasting was carried out and the other group was given enough food which was labelled as control group. It was found that the group that performed intermittent fasting had only partial growth of hair even after 90 days. On the other hand, within 30 days, the control group had most of the hair grown.

Final comments

AFSCI is proving to be pivotal in restoring hair and regaining lost confidence. Moreover, with advancing technology, researchers have determined novel approaches to treat the widespread problem of loss of hair. The advantages of AFSCI in hair loss range from reduction in hair fall to improvement in hair texture.

AFSCI will establish itself as a permanent breakthrough solution for stem cells for hair loss in the coming years.

FAQs

Q: How does exosome therapy restores hair growth?

Exosomes release growth factors and cytokines which trigger the follicular activity and stimulates growth of hair. In addition, they also release IL-10 and TGF-β which aids in hair growth. Furthermore, exosomes also promote angiogenesis. Thus, the benefit is that it nourishes the follicles of the hair by improving blood supply.

Q: What are the common causes of hair loss?

The causes that constitute the hair loss are bacterial and fungal infections, trauma, pregnancy, certain conditions and drugs, genetics and stress. 

Q: Define the term Alopecia Areata?

Alopecia Areata is condition of autoimmunity which causes temporary or permanent loss of hair either in patches or covers the entire head. 

Q: What is PRP therapy?

PRP therapy is a therapy which involves isolating concentrated platelets from the patient’s blood and injecting in the scalp. The platelets concentrate is rich in growth factors and cytokines. Moreover, the role of these growth factors is to stimulate the follicles of hair since follicles help in regenerating growth of the hair.