COVID-19 has impacted our lives in many ways, pertaining to the damage it has caused to healthcare globally. Coronavirus causes hypoxic respiratory failure and acute respiratory distress syndrome, which can result in multiple organ failures. Despite breakthroughs in supportive care measures, there is still a paucity of clinically viable medicines, and fresh strategies to combat this disease are urgently needed. Stem cell therapy and stem cell-derived organoid models are increasingly gaining attention as a new treatment and research tool for COVID-19.
Primarily mesenchymal stem cells (MSCs) are capable of robust immune modulation and tissue damage repair. MSCs and lung stem/progenitor cells (LSCs) have been commonly used in the treatment of viral infections and other disorders, including acute lung injury (ALI). Since the COVID-19 emergence, mesenchymal stem cell (MSC) therapy has also received attention. MSCs have been found in recent studies to significantly suppress the severe inflammatory response in SARS-CoV-2 patients, minimize lung injury, enhance lung capacity, damage lung recovery, and play a favourable role in relieving lung damage in COVID-19 patients.
Stem Cells for Post-Covid
Stem cell therapy entails generating new, normal, younger cells, tissues, and even micro organs in vitro through stem cell isolation, culture, and controlled differentiation, and then transplanting them to specified regions of the body instead of damaged or dead cells, restoring body functioning. Stem cell therapy for lungs is available not only for severe COVID-19 patients but also for individuals who have recovered from severe COVID-19 issues or are dealing with long covid, making it appropriate COVID-19 treatment.
Mechanism of Stem Cell Therapy for Post Covid
The primary reason for the development of severe COVID-19 individuals is immune dysfunction. Cytokines and inflammation play a key role in the development of COVID-19-induced lung damage, immunological treatments capable of reducing cytokine storms may be the most effective therapy choices. The conventional immunomodulatory capability of typical immunotherapeutic, on the other hand, is focused on one or two parameters, which may not elicit a robust response. MSCs have shown significant and vast immunomodulatory and anti-inflammatory capacity, suggesting that MSC-based therapy could be an appropriate cure for COVID-19. Furthermore, because of their regenerative potential, MSCs can enhance tissue regeneration in order to minimize long-term lung damage caused by COVID-19.
MSCs have been demonstrated to stabilize endothelial fluid leakage and regulate alveolar-capillary barrier function, which is critical for maintaining or decreasing lung permeability due to inflammation and therefore slowing the progression of lung diseases.
Advancing Stem Cell Therapy For Covid-19 to Forefront Medical Research
MSCs may be the most promising therapy option for SARS-CoV-2 infections. Since the control of the cytokine storm in the lungs is critical for the therapy of Covid infection, MSCs are well-suited because their major mechanism of action is via their immunomodulatory and anti-inflammatory capabilities. Depending on the outcomes of a number of completed clinical trials evaluating the therapeutic effects of MSCs in lung disorders, their safety profile and efficacy are well-established.
Presently, a vast majority of clinical trials are being conducted for patients dealing with long Covid. Many of these clinical trials have shown noticeable improvements in pulmonary functions as well as a significant reduction of inflammation in the lungs.
Simultaneously, present findings suggest that a worldwide integrated approach and support is required to conduct comprehensive clinical trials to establish the feasibility and efficacy of different types of stem cells in treating COVID-19-related health issues. It also implies that there is a need for extensive research to find the most appropriate stem cell types for treating Covid-induced respiratory complications.
If you want to know more about stem cells for lung-related complications, get in touch with us. At Advancells, we are committed to providing you with the finest quality cells for lungs in India.