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Stem cell therapy for Amyotrophic Lateral Sclerosis(ALS)


Stem Cell Treatment For Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis, most commonly called as the Lou Gehrig's disease or motor neuron disease is a type of a progressive neurological illness that manifests as gradual weakening and atrophy of muscles. This progression of the disease can go upto as many as two to five years but in very rare cases a person can live upto seven years with 100% fatal outcome.

Our brain has a network of cells known as neurons, which precisely act as a medium; passing the important information originated from brain to different other parts of the body. Likewise the brain is sectioned into different region for controlling different functions. Amyotrophic Lateral Sclerosis is the degeneration of neurons, in the motor cortex region of the brain, controlling voluntary movements. The factors such as excessive protein flakes generation or external shocks or sometimes may be genetic mutations are responsible for such degeneration due to which ability of neurons to pass on the signals to the muscles is lost or hampered. As muscles do not get any information about movement from the brain, their work is interrupted and they become progressively weak.


Major Manifestations of ALS, in patients include the following:

  • Weakness
  • Muscle Pain
  • Disorder of speech and swallowing
  • Spasticity
  • Increased deep reflexes
  • Pathological reflexes
  • Fibrillations
  • Atrophy
  • Respiratory syndromes or malfunctions
  • Uncontrolled movements such as laughter or cry
  • Depressions

Conventional treatment approach to ALS showed serious contraindications such as respiratory failure, grade III artificial lung ventilations, dysphasia and presence of gastric stroma. Stem cells are the master cells, isolated from our own body, enriched in the laboratory and re-infused back into the body to harness their full potential of differentiating into desired cell types. With number of patients opting stem cells treatment for ALS , it has been observed from the post transplant data that infusion of stem cells, do not combat the immediate cause of the disease but have exerted substantial influences on links of the pathological diseases and slowing down the disease progression.

List of diseases treated

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Stem Cell Treatment

Stem Cell Treatment For ALS: Advancells Protocol

At Advancells, we have been successfully treating patients with ALS, using Autologous stem cells from Bone Marrow and Adipose Tissue. Our top priority is to provide a comprehensive, individualized treatment pattern which is best suited for patients undergoing treatment.

Indications of ALS treatment with stem cells may include confirmed ALS diagnosis, disease progression and failure of the conventional treatment options. Worldwide, many clinical trials have been implemented to analyse the safety and efficacy of the stem cells treatment for ALS patients.

Through our multidisciplinary team of specialists; we are giving the best supportive post therapy care to improve our outcome.

Step 1- Qualification For The Treatment

A safety and efficacy assessments will be prescribed by our experts in order to investigate the stage of severity and qualify the patient for the treatment. Following pretreatment assessments can be suggested depending upon the patient's medical and family background:

Pre-Treatment Assessments

  • Routine Blood Tests
  • Infectious Diseases Testing
  • Urine Analysis
  • Physical Examination
  • X Ray

Pre-Operative Assessments

  • Surgical Correction
  • MRI
  • CT Scan
  • Medical History

As per these results, the patient will be counselled further for final decision of protocol.

Step 2- Source Extraction

With the physician's approval and guidance, the source from which stem cells are to be collected is decided. In general patient can be prescribed, stem cells isolation from Bone Marrow or Adipose Tissue, as these are the most potent Autologous sources available. However, in certain cases, both sources can be utilized for a better outcome. Doctors can also suggest stem cells stimulation therapy for some of the patients, depending upon the severity and requirement.

The specified amount of sample will be extracted from the patient's own body on the intimated date and time, with the application of local anaesthesia. The entire procedure takes around 7-8 hrs, however, in case of extraction from both the sources the patient has to be with us for a little longer time.

If you are curious to know more about the procedure, kindly refer our detailed snapshot below :

Stem Cell Therapy Procedure for ALS

Step 3- Laboratory Processing

The extracted sample, will be sent to the government approved cGMP laboratory for processing. The sample processing will be done in a state of the art class 10,000 clean room in compliance with the ISO and GMP standards.

The sample will undergo minimum manipulation in our complete automated Sepax technology to be enriched with the pure population of stem cells culture. The isolated stem cells will be characterized for quality, purity and viability.

The client will be given a third party certificate from Internationally Accredited Lab for the quality purpose.

Step 4- Stem Cell Implantation

Once stem cells are enriched and ready to be injected back into the body, we have worked on different modes of implanting them. However, depending upon the patient's physiological and mental well being, one of the following will be finalized by our experts.

  • Intravenous Injection:- Stem cells will be infused into the body, by infusing through the vein.
  • Intra-thecal Injection:- Stem cells will be infused, into the cerebro-spinal fluid of the spinal cord. This route is most popularly known as Lumbar Puncture.

Follow up Treatment

In a post treatment care, the patient will be asked to visit the doctors after a specific period of time, for some rehabilitation programmes including Behavioural and emotional development, Communication and social Interaction, Self regulation, Cognitive and Adaptive skills.



ALS Stem Cell Treatment Results

In totality, there were 32 patients who were diagnosed previously to have had ALS. They underwent stem cell treatment at Advancells and we followed their progress. Many of the them have reported notable relief from fatigue, muscles cramp, excessive secretion of saliva or phlegm. Almost all of them have gained good control over constipation, sleeping disturbances, mood swings and speech.(Read more...)

Patient's Stories

Mr.Sudheendra Hola, 34 Years Old MND

"Mr Sudheendra Hola, 34 years old, is a financial adviser from Bangalore. He was healthy and had a successful career until one day in 2016 when he started feeling breathless and had difficulty walking. A visit to the doctor followed by a battery of tests, diagnosed him with Motor Neuron Disease..."

Mr. Fida Mohammad, 63 years, ALS

"Mr. Fida Mohammad, 63 years from Peshawar Pakistan was a healthy and active gentleman till about 5 years ago when he started feeling some weakness in the thumb on the left leg. Slowly, he stared getting incidences of foot drop and within one year of starting of symptoms he was unable to walk and was confined to a wheel chair...."

Mr Rehman, 60 years old, ALS

Mr. Rehman opted for stem cell therapy with Advancells in August 2014 with the hope of stopping the progression of the disease

Click to view or print complete ALS results including graphs

Astrid Rabell, 66 years, ALS

"It has been 3 months since my ALS Therapy. For about a year before my treatment I had been searching on the internet for any..."

Jorge C., 63 years, ALS

"There is always hope, so you may want to consider taking this treatment..."



Stem cell therapy video for MND
Mr Sudheendra Hola, MND Patient Video, Bangalore
Stem cell therapy video for ALS
Rafiq Ahmad, ALS Patient video, Pakistan
Stem cell video therapy for ALS
Fida Mohammad ALS Patient video, Pakistan
Stem cell video therapy for ALS
ALS Patient video, Norway
More Video



Frequently Asked Questions

  • What Is ALS?
  • ALS is the disease affecting the brain cells popularly known as neurons connecting brain with other parts of the body. These neurons act as messengers to transmit signals from brain to muscles to allow the voluntary movements of the body. Due to some external or internal factors, these cells die or degenerate thereby losing the ability to transmit signals to muscles. This cause the muscles to be weak leading to paralysis.
  • What Causes ALS ?
  • Although, ALS has been very prevalent worldwide, scientists are still brainstorming to know the exact cause and mechanism for ALS. There have been so far various studies to analyse different facets, which could be linked up with ALS. Although studies are correlating the disease for most genetic variations, there is yet far to be understood.
  • Is ALS linked to the environment ?
  • Clinical studies so far have not found definitive environmental factors that can be linked with ALS apart from some generalized studies relating it to the possible exposure of certain chemicals like lead or mercury.
  • Is ALS equally common in both the genders ?
  • ALS, which has been induced due to some environmental factors, is observed to be slightly more common in men than in women. However it has also been reported recently that the difference is decreasing over the time. At the same time, familial ALS i.e. ALS associated with the genetic variations is equally common in both the genders.
  • Is ALS related to age?
  • ALS is generally age related; most of the people find out that they are suffering with ALS when they are between 55-75 years of age.
  • How long do people with ALS live?
  • Most of the people with ALS have observed to be living for 3 to 5 years after the symptoms can develop. Although the exact life of the person with ALS have been related to age.
  • Can ALS be inherited ?
  • It has been observed that almost about 5-10% of the total ALS cases are familial ALS i.e. they are mostly caused due to the defect in the gene which is commonly known as "SOD1"
  • What is a motor neuron disease?
  • ALS falls under a group of conditions known as motor neuron disease. In ALS, muscles involved in the voluntary movements of both upper and lower body are affected. On an average, ALS generally accounts for the 85% of motor neuron diseases.
  • Where can I get more information about ALS
  • Please go through, our ALS treatment brochures for other ALS related information.

What can you expect?

Many ALS patients after stem cell treatment reported to be exhibiting:

  • Diminished Weakness.
  • Improvement of Mood & Appetite.
  • Decreased intensity of plasticity.
  • Decrease in muscular rigidity and improved muscular strength.
  • Better Sensory functions
  • Normalisation of reflexes.
  • Better tolerability of daily chores.
  • Reduction in the intensity of dysphasia.
  • Slow down or halt in progression of the disease.
  • Improved food consumption