PRP Therapy for Wound Healing– Over the years, different therapeutic alternatives have been developed for skin healing by scientists worldwide, due to its scientific, clinical as well as economic outcome. Wound healing is rather a complex process with its own unique dynamics. The healing is often associated with a process that involves complete wound sealing, along with the formation of a new skin matrix. Although, it should as well be noted that some acute, as well as chronic versions of wounds, can be difficult to heal, as a result of other comorbidities and opportunistic infections. As a matter of fact, even a better wound care regimen cannot always be leading towards a better wound healing.
In this regard, patients own Platelet Rich Plasma has been well identified since more than two decades to be an advanced treatment that is highly effective for many chronic as well as acute wounds. PRP or Platelet Rich Plasma is the enriched fraction of patient’s own blood, so much so that it is been enriched above the baseline values of normal platelets. Studies have indicated that this clear suspension holding red cells, white cells and platelets can effectively activate clotting mechanism while releasing various different proteinaceous growth factors that are essential for rapid healing and closure. Hence, it is being exploited as the effective component in many periodontal, maxillofacial as well as orthopedic surgery; apart from being an active treatment ingredient for skin issues and ulcers.
Practically, a PRP session is being implemented in a very fast and relatively easy way; not investing more than an hour for the completion. 30 ml of blood will be withdrawn from one of your forearms and will be transferred into a sterile tube, further preventing its clotting. The Platelet Rich fraction will be processed and enriched in a controlled environment that is clinically approved through reputed regulatory authorities. Prepared PRP serum will be infused back at the site of injury, in combination with stem cells to allow faster recovery.
Platelets basically help in offering structural support and building up of matrix to regenerate damaged organelles of the tissues. Their identified secretions, such as platelet-derived growth factors, transforming growth factors, angiogenesis factors, vascular endothelial growth factors, etc. allow speedy epithelization and faster sealing of the area of the chronic wound. The important storage organelles of platelets, such as dense and alpha granules will activate the immunoregulatory mechanisms to kick-start rapid healing processes, through.
Inflammation: In order to remove harmful stimuli of body’s own immune cells and offer further protection against damaged cells, irritants as well as pathogens.
Regeneration: New cells are being regenerated quickly, to restore functional attributes of damaged tissues.
Recreation: New vasculature is being recreated to allow rapid blood circulation for easy passage.
Moreover, the platelet enriched PRP can as well play an important role in offering host defense mechanism; around the site of the exposed wound by eliciting different chemical signaling pathways to attract immune warriors like macrophages, white blood cells and interleukins for the complete protection from infection.
Accordingly, various clinical studies have confirmed the feasibility, safety as well as the efficacy of the said topical growth factor supplements as an effective adjuvant for offering complete wound care solution.